Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9498-9510

  Fracchiolla, Giuseppe ^a   Lavecchia, Antonio ^b   Laghezza, Antonio ^a   Piemontese, Luca ^a   Trisolini, Raffaella ^a   Carbonara, Giuseppe ^a   Tortorella, Paolo ^a   Novellino, Ettore ^b   Loiodice, Fulvio ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Chirality; Docking; MM PBSA; Molecular dynamics; Peroxisome proliferator activated receptor

Indexed keywords

2 (4 CHLOROPHENOXY) 3 PHENYLPROPANOIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL;

BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR ALPHA; PPAR GAMMA; PROPIONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 53749083135     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.045     Document Type: Article

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