Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor

Journal of Neuroscience

Volumn 21, Issue 5, 2001, Pages 1501-1509

  Gardoni, F ^a   Schrama, L H ^b   Kamal, A ^b   Gispen, W H ^b   Cattabeni, F ^a   Di Luca, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

LTP; NMDA; Postsynaptic density; PSD 95; Synaptic plasticity; CaMKII

Indexed keywords

ALANINE; ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN); RECEPTOR SUBUNIT; RECOMBINANT ENZYME; SERINE;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT;

EID: 0035282948     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-05-01501.2001     Document Type: Article

References (41)

1. 2+/calmodulin-dependent protein kinase II in postsynaptic densities after reversible cerebral ischemia in rats
2. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
3. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP-97
4. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C
5. CaM KII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP
6. Isolation and characterization of post synaptic densities from various brain regions: Enrichment of different types of post synaptic densities
7. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
8. NMDA receptor subunits are modified transcriptionally and post-translationally in the brain of streptozotocin-diabetic rats
9. Ischemia-induced modifications of protein components of rat brain postsynaptic densities
10. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy
11. Synaptic targeting of glutamate receptors
12. 2+/calmodulin-dependent protein kinase II and its endogenous substrates in the induction of long-term potentiation
13. NR2A/B subunits of NMDA receptor as anchors for CaM KII in post synaptic densities
14. αCaM KII binding to the C-terminal tail of NMDA receptor subunit N R2A and its modulation by autophosphorylation
15. Cloned glutamate receptors
16. The postsynaptic densities at glutamatergic synapses
17. Signal transduction molecules at the glutamatergic postsynaptic membrane
18. Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins
19. Domain interaction between NMDA receptor subunits and the post synaptic density protein PSD-95
20. Interaction of N-methyl-D-aspartate receptor complex with a novel synapse-associated protein. SAP-102
21. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor
22. 2+/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation
23. Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II
24. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
25. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
26. The major tyrosine phosphorylated protein in the post synaptic density fraction is N-methyl-D-aspartate receptor subunit 2B
27. Identification of a phosphorylation site for calcium/calmodulin dependent protein kinase II in the N R2B subunit of the N-methyl-D-aspartate receptor
28. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
29. Dynamic control of CaM KII translocation and localization in hippocampal neurons by NMDA receptor stimulation
30. Single-step purification of polypeptides expressed in E. coli as fusions with glutathione S-transferase
31. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
32. Autophosphorylation-dependent targeting of calcium calmodulin kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor
33. Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density
34. 2+/calmodulin-dependent protein kinase II into postsynaptic density after decapitation
35. Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia
36. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit N R2A
37. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin
38. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor
39. Modulation of the channel activity of the ε2/ζ1-subtype N-methyl-D-aspartate receptor by PSD-95
40. NMDA channel regulation by channel-associated protein tyrosine kinase src
41. Enlightening the postsynaptic density