The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila

Developmental Cell

Volumn 15, Issue 4, 2008, Pages 568-577

  Layalle, Sophie ^a   Arquier, Nathalie ^a   Léopold, Pierre ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

CELLBIO

Indexed keywords

ECDYSONE; TARGET OF RAPAMYCIN KINASE;

ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIET RESTRICTION; DROSOPHILA; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONE RELEASE; INSECT CELL; INSECT DEVELOPMENT; LARVAL DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PUPATION; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; ECDYSONE; FOOD; IMMUNOHISTOCHEMISTRY; LARVA; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS;

ANIMALIA; METAZOA;

EID: 53249094103     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2008.08.003     Document Type: Article

References (54)

1. Beadle G., Tatum E., and Clancy C. Food level in relation to rate of development and eye pigmentation in Drosophila melanogaster. Biol. Bull. 75 (1938) 447-462
2. Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., and Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11 (2001) 213-221
3. Caldwell P.E., Walkiewicz M., and Stern M. Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release. Curr. Biol. 15 (2005) 1785-1795
4. Chavez V.M., Marques G., Delbecque J.P., Kobayashi K., Hollingsworth M., Burr J., Natzle J.E., and O'Connor M.B. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels. Development 127 (2000) 4115-4126
5. Colombani J., Raisin S., Pantalacci S., Radimerski T., Montagne J., and Leopold P. A nutrient sensor mechanism controls Drosophila growth. Cell 114 (2003) 739-749
6. Colombani J., Bianchini L., Layalle S., Pondeville E., Dauphin-Villemant C., Antoniewski C., Carre C., Noselli S., and Leopold P. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310 (2005) 667-670
7. Dan H.C., Sun M., Yang L., Feldman R.I., Sui X.M., Ou C.C., Nellist M., Yeung R.S., Halley D.J., Nicosia S.V., et al. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem. 277 (2002) 35364-35370
8. Dann S.G., and Thomas G. The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett. 580 (2006) 2821-2829
9. Day S.J., and Lawrence P.A. Measuring dimensions: the regulation of size and shape. Development 127 (2000) 2977-2987
10. De Moed G.H., Kruitwagen C.L., De Jong G., and Scharloo W. Critical weight for the induction of pupariation in Drosophila melanogaster: genetic and environmental variation. J. Evol. Biol. 12 (1999) 852-858
11. Dong J., and Pan D. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18 (2004) 2479-2484
12. Drop S.L., Greggio N., Cappa M., and Bernasconi S. Current concepts in tall stature and overgrowth syndromes. J. Pediatr. Endocrinol. Metab. 14 Suppl 2 (2001) 975-984
13. Edgar B.A. How flies get their size: genetics meets physiology. Nat. Rev. Genet. 7 (2006) 907-916
14. Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S., Ru B., and Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 4 (2002) 699-704
15. Geminard C., Arquier N., Layalle S., Bourouis M., Slaidina M., Delanoue R., Bjordal M., Ohanna M., Ma M., Colombani J., and Leopold P. Control of metabolism and growth through insulin-like peptides in Drosophila. Diabetes 55 Suppl 2 (2006) S5-S8
16. Gilbert L.I., Rybczynski R., and Warren J.T. Control and biochemical nature of the ecdysteroidogenic pathway. Annu. Rev. Entomol. 47 (2002) 883-916
17. Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 (2007) 9-22
18. Harrington L.S., Findlay G.M., Gray A., Tolkacheva T., Wigfield S., Rebholz H., Barnett J., Leslie N.R., Cheng S., Shepherd P.R., et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166 (2004) 213-223
19. Hietakangas V., and Cohen S.M. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 21 (2007) 632-637
20. Huang J., and Manning B.D. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem. J. 412 (2008) 179-190
21. Layalle S., Coessens E., Ghysen A., and Dambly-Chaudiere C. Smooth, a hnRNP encoding gene, controls axonal navigation in Drosophila. Genes Cells 10 (2005) 119-125
22. Manning B.D., Tee A.R., Logsdon M.N., Blenis J., and Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10 (2002) 151-162
23. McBrayer Z., Ono H., Shimell M., Parvy J.P., Beckstead R.B., Warren J.T., Thummel C.S., Dauphin-Villemant C., Gilbert L.I., and O'Connor M.B. Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev. Cell 13 (2007) 857-871
24. Meyer C.A., Jacobs H.W., Datar S.A., Du W., Edgar B.A., and Lehner C.F. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 19 (2000) 4533-4542
25. Mirth C., Truman J.W., and Riddiford L.M. The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 (2005) 1796-1807
26. Mirth C.K., and Riddiford L.M. Size assessment and growth control: how adult size is determined in insects. Bioessays 29 (2007) 344-355
27. Nijhout H.F. The control of body size in insects. Dev. Biol. 261 (2003) 1-9
28. Oldham S., Montagne J., Radimerski T., Thomas G., and Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14 (2000) 2689-2694
29. Parvy J.P., Blais C., Bernard F., Warren J.T., Petryk A., Gilbert L.I., O'Connor M.B., and Dauphin-Villemant C. A role for βFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster. Dev. Biol. 282 (2005) 84-94
30. Patel P.H., Thapar N., Guo L., Martinez M., Maris J., Gau C.L., Lengyel J.A., and Tamanoi F. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. J. Cell Sci. 116 (2003) 3601-3610
31. Potter C.J., Huang H., and Xu T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105 (2001) 357-368
32. Potter C.J., Pedraza L.G., and Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4 (2002) 658-665
33. Radimerski T., Montagne J., Hemmings-Mieszczak M., and Thomas G. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev. 16 (2002) 2627-2632
34. Radimerski T., Montagne J., Rintelen F., Stocker H., van der Kaay J., Downes C.P., Hafen E., and Thomas G. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat. Cell Biol. 4 (2002) 251-255
35. Riddiford L.M. Hormone receptors and the regulation of insect metamorphosis. Receptor 3 (1993) 203-209
36. Riddiford L.M., Cherbas P., and Truman J.W. Ecdysone receptors and their biological actions. Vitam. Horm. 60 (2000) 1-73
37. Robertson F.B. The ecological genetics of growth in Drosophila 6. The genetic correlation between the duration of the larval period and body size in relation to larval diet. Genet. Res. 4 (1963) 74-92
38. Rulifson E.J., Kim S.K., and Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296 (2002) 1118-1120
39. Rybczynski R. Prothoracicotropic hormone. In: Gilbert L.I., Iatrou K., and Gill S. (Eds). Comprehensive Molecular Insect Science (2005), Elsevier, Oxford 61-123
40. Rybczynski R., and Gilbert L.I. Protein kinase C modulates ecdysteroidogenesis in the prothoracic gland of the tobacco hornworm, Manduca sexta. Mol. Cell. Endocrinol. 251 (2006) 78-87
41. Rybczynski R., Bell S.C., and Gilbert L.I. Activation of an extracellular signal-regulated kinase (ERK) by the insect prothoracicotropic hormone. Mol. Cell. Endocrinol. 184 (2001) 1-11
42. Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
43. Shingleton A.W., Das J., Vinicius L., and Stern D.L. The temporal requirements for insulin signaling during development in Drosophila. PLoS Biol. 3 (2005) e289
44. Shingleton A.W., Frankino W.A., Flatt T., Nijhout H.F., and Emlen D.J. Size and shape: the developmental regulation of static allometry in insects. Bioessays 29 (2007) 536-548
45. Siegmund T., and Korge G. Innervation of the ring gland of Drosophila melanogaster. J. Comp. Neurol. 431 (2001) 481-491
46. Song Q., and Gilbert L.I. S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: a role for S6 kinase. Dev. Genet. 15 (1994) 332-338
47. Song Q., and Gilbert L.I. Multiple phosphorylation of ribosomal protein S6 and specific protein synthesis are required for prothoracicotropic hormone-stimulated ecdysteroid biosynthesis in the prothoracic glands of Manduca sexta. Insect Biochem. Mol. Biol. 25 (1995) 591-602
48. Stearns S.C. Life history evolution: successes, limitations, and prospects. Naturwissenschaften 87 (2000) 476-486
49. Tapon N., Ito N., Dickson B.J., Treisman J.E., and Hariharan I.K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105 (2001) 345-355
50. Tee A.R., Fingar D.C., Manning B.D., Kwiatkowski D.J., Cantley L.C., and Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc. Natl. Acad. Sci. USA 99 (2002) 13571-13576
51. Wang T., Hung C.C., and Randall D.J. The comparative physiology of food deprivation: from feast to famine. Annu. Rev. Physiol. 68 (2006) 223-251
52. Warren J.T., Petryk A., Marques G., Parvy J.P., Shinoda T., Itoyama K., Kobayashi J., Jarcho M., Li Y., O'Connor M.B., et al. Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis. Insect Biochem. Mol. Biol. 34 (2004) 991-1010
53. Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
54. Zhang H., Stallock J.P., Ng J.C., Reinhard C., and Neufeld T.P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14 (2000) 2712-2724