Control and biochemical nature of the ecdysteroidogenic pathway

Annual Review of Entomology

Volumn 47, Issue , 2002, Pages 883-916

  Gilbert, Lawrence I ^a   Rybczynski, Robert ^a   Warren, James T ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cyclic AMP; Ecdysone; Molting; Protein kinase; Prothoracicotropic hormone; Steroid hormone

Indexed keywords

ARTHROPOD; BIOCHEMISTRY; MOLT;

ARTHROPODA;

ECDYSTEROID;

ANIMAL; BIOSYNTHESIS; DOWN REGULATION; INSECT; METABOLISM; REVIEW;

ANIMAL; DOWN-REGULATION; ECDYSTEROIDS; INSECTS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0036006850     PISSN: 00664170     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ento.47.091201.145302     Document Type: Review

References (190)

1. Cellular localization of the insect prothoracicotropic hormone: In vitro assay of a single neurosecretory cell
2. Evidence for a clade of nematodes, arthropods and other moulting animals
3. FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex
4. 4,7,93-keto-steroid hormones
5. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
6. Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer
7. Sequence and developmental expression of Cyp 18, a member of a new cytochrome P450 family from Drosophila
8. Interaction of steroid hormone receptors with the transcription initiation complex
9. The biological activities of ecdysteroids and ecdysteroid analogues
10. Feedback inhibition of ecdysone production by 20-hydroxyecdysone in Pieris brassicae pupae
11. Intracellular calcium in prothoracic glands of Manduca sexta
12. Pharmacological study of signal transduction during stimulation of prothoracic glands from Manduca sexta
13. Photo-oxygenation of 3-acetoxyergosta-3,5,7,22-tetraene and related compounds
14. 4 intermediates in ecdysteroid biosynthesis
15. Ecdysteroid formation from 25-hydroxycholesterol by arthropod molting glands in vitro
16. In vitro metabolism of possible ecdysone precursors by the prothoracic glands of the tobacco hornworm, Manduca sexta
17. 3H]5-cholest-7-en-6-one by the prothoracic glands of Manduca sexta
18. Ecdysteroid titer during larval-pupal-adult development of the tobacco hornworm, Manduca sexta
19. The biosynthesis of steroids and triterpenoids
20. The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels
21. Purification of ecdysone oxidase and 3-dehydroecdysone 3α-reductase from the cotton leafworm, Spodoptera littoralis
22. Molecular cloning and characterization of hemolymph 3-dehydroecdysone 3β-reductase from the cotton leafworm, Spodoptera littoralis - A new member of the third superfamily of oxidoreductases
23. 125I]Iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors
24. Ultrastructural analysis of pathologic lesions in sterol-deficient Nippostrongylus brasiliensis larvae
25. Polyamines modulate multiple protein phosphorylation pathways in the insect prothoracic gland
26. The stereochemistry of hydrogen elimination from C-7 during biosynthesis of ecdysones in insects and plants
27. Evidence that the FK-506-immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus
28. The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor
29. Metamorphosis of the corpus allatum and degeneration of the prothoracic glands during the larvalpupal-adult transformation of Drosophila melanogaster: A cytophysiological analysis of the ring gland
30. Programmed cell death of the prothoracic glands of Manduca sexta during pupal-adult metamorphosis
31. Towards the elucidation of the ecdysteroid biosynthetic pathway
32. Alternative sites for ecdysteroid production in insects
33. The steroid and thyroid hormone superfamily
34. Makisterone C: A 29-carbon ecdysteroid from developing embryos of the cotton stainer bug, Dysdercus fasciatus
35. S6 phosphorylation and the p70s6k/p85s6k
36. The role of phytosterols in host plant utilization by cactophilic Drosophila
37. Modeling human neurodegenerative diseases in Drosophila on a wing and a prayer
38. The dare gene: Steroid hormone production, olfactory behavior, and neural degeneration in Drosophila
39. Mechanism of the conversion of fucosterol epoxide into desmosterol in insects. The stereochemical fate of the diastereotopic C-26 and C-27 methyl groups of the epoxide
40. C-25 prochirality in the fragmentation reaction catalysed by fucosterol epoxide lyase from the silkworm, Bombyx mori
41. 24-reductase of the silkworm, Bombyx mori
42. Biosynthesis of sterols and ecdysteroids in Ajuga hairy roots
43. Hormonal regulation in insects: Facts, gaps, and future directions
44. Role of ecdysone in Drosophila development
45. Low molecular weight ecdysiotropins in proctodaea of fifth instars of the tobacco hornworm, Manduca sexta (Lepidoptera: Sphingidae), and hosts parasitized by the braconid wasp Cotesia congregata (Hymenoptera: Braconidae)
46. Aedes aegypti TMOF modulates ecdysteroid production by prothoracic glands of the gypsy moth Lymantria dispar
47. The insect gut: A new source of ecdysiotropic peptides
48. Maintenance of the prothoracic gland by the juvenile hormone in insects
49. Lipid metabolism and function in insects
50. Neuropeptides, second messengers and insect molting
51. The juvenile hormones: Historical facts and speculations on future research directions
52. Dynamic regulation of prothoracic gland ecdysteroidogenesis: Manduca sexta recombinant prothoracicotropic hormone and brain extracts have identical effects
53. Control of ecdysteroidogenesis: Activation and inhibition of prothoracic gland activity
54. Investigation of presumptive mobilization pathways for calcium in the steroidogenic action of big prothoracicotropic hormone
55. Metabolism of lathosterol by Drosophila pachea
56. Insulin-mediated secretion of ecdysteroids from mosquito ovaries and molecular cloning of the insulin receptor homologue from ovaries of bloodfed Aedes aegypti
57. Early steps in ecdysteroid biosynthesis: Evidence for the involvement of cytochrome P-450 enzymes
58. A putative route to ecdysteroids: Metabolism of cholesterol in vitro by mildly disrupted prothoracic glands of Manduca sexta
59. A deficiency in prothoracicotropic hormone transduction pathway during the early last larval instar of Bombyx mori
60. Role of calcium in the stimulation of ecdysteroidogenesis by recombinant prothoracicotropic hormone in the prothoracic glands of the silkworm, Bombyx mori
61. 2-22,23)-2,22-dideoxyecdysone: Tissue distribution of the C-22 hydroxylase in Locusta migratoria
62. 4]3β-hydroxy-5β-cholest-7-ene-6-one: Critical re-evaluation of its role in Locusta migratoria
63. Ultrastructure of prothoracic glands during larval-pupal development of the tobacco hornworm, Manduca sexta: A reappraisal
64. Regulation of membrane cholesterol domains by sterol carrier protein-2
65. Stimulation of ecdysteroidogenesis by small prothoracicotropic hormone: Role of calcium
66. 7,22 sterols
67. Unique sterol in the ecology and nutrition of Drosophila pachea
68. Comparison of ecdysteroid production in Drosophila and Manduca: Pharmacology and cross-species neural reactivity
69. Peptide hormones, steroid hormones and puffs: Mechanisms and models in insect development
70. A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue
71. Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide from Locust migratoria
72. Identification of a prothoracicostatic peptide in the larval brain of the silkworm, Bombyx mori
73. Structure, mechanism, and regulation of mammalian adenylyl cyclase
74. Assignment of disulfide bond location in prothoracicotropic hormone of the silkworm, Bombyx mori: A homodimeric protein
75. The brain secretory peptides that control moulting and metamorphosis of the silkmoth Bombyx mori
76. Identification and mRNA developmental profiles of two ultraspiracle isoforms in the epidermis and wings of Manduca sexta
77. Developmental profiles and ecdysteroid regulation of the mRNAs for two ecdysone receptor isoforms in the epidermis and wings of the tobacco hornworm, Manduca sexta
78. Transcriptional regulation of steroid hydroxylase genes by corticotropin
79. Synthesis and reactions of 5α,8-epidioxyandrost-6-enes
80. Investigation of intermediate steps in the biosynthesis of ecdysterone from cholesterol in Podocarpus elata
81. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome
82. Ecdysone analog: Conversion to alpha ecdysone and 20-hydroxyecdysone by an insect
83. Enzymes involved in ecdysone biosynthesis
84. Temporal coordination of regulatory gene expression by steroid hormone ecdysone
85. Molecular cloning of the Bombyx mori prothoracicotropic hormone
86. A family of cAMP-binding proteins that directly activate Rap1
87. 26-Hydroxylation of ecdysteroids is catalyzed by a typical cytochrome P-450-dependent oxidase and related to ecdysteroid resistance in an insect cell line
88. Involvement of translation and transcription in insect steroidogenesis
89. Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster
90. Prothoracic gland synthesis of 3-dehydroecdysone and its hemolymph 3β-reductase mediated conversion to ecdysone in representative insects
91. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
92. Ecdysone oxidase in insects
93. Studies on the necessity of the brain for the inception of insect metamorphosis
94. An FK-506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones
95. Studies on the biosynthesis of ecdysone by the Y-organs of Carcinus maenas
96. Understanding insect endocrine systems: Molecular approaches
97. Addition to steroid polyenes IV
98. Choline acetyltransferase activity in the larval brain of Manduca sexta
99. Signal transduction through MAP kinase cascades
100. Transduction of the signal initiated by the neuropeptide, testis ecdysiotropin, in testes of the gypsy moth, Lymantria dispar
101. A novel neuropeptide-endocrine interaction controlling ecdysteroid production in ixodid ticks
102. Cyclic AMP-dependent and independent stimulations of ovarian steroidogenesis by brain factors in the blowfly, Phormia regina
103. Conversion of a radiolabelled ecdysone precursor, 2,22,25-trideoxyecdysone, by embryonic and larval tissues of Locusta migratoria
104. A calmodulin-sensitive adenylate cyclase in the prothoracic glands of the tobacco hornworm, Manduca sexta
105. Developmental regulation of calmodulin-dependent adenylate cyclase in an insect endocrine gland
106. Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A
107. Early stages of ecdysteroid biosynthesis: The role of 7-dehydrocholesterol
108. Developmental profile of the changes in the prothoracicotropic hormone titer in hemolymph of the silkworm Bombyx mori: Correlation with ecdysteroid secretion
109. Fucosterol-24,28-epoxide, as a probable intermediate in the conversion of β-sitosterol to cholesterol in the silkworm
110. Purification and properties of the prothoracicotropic hormone of the silkworm, Bombyx mori
111. Insect hormones. The structure of ponasterone A, an insect moulting hormone from the leaves of Podocarpus nakaii Hay
112. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome
113. Relationship between the product of the Drosophila Ultraspiracle locus and the vertebrate retinoid X receptor
114. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
115. Steroid receptor interaction with heat shock protein and immunophilin chaperones
116. Neurosecretion: Peptidergic systems in insects
117. Fucosterol epoxide lyase of insects: Synthesis of labeled substrates and development of a partition assay
118. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts
119. Evidence for the presence of makisterone A in Drosophila larvae and the secretion of 20-deoxymakisterone A by the ring glands
120. Ecdysteroid biosynthesis and inactivation in relation to function
121. A neuroendocrine releasing effect of melatonin in the brain of an insect, Peri-planeta americana (L.)
122. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti
123. Protein phosphorylation in the prothoracic glands as a cellular model for juvenile hormone-prothoracicotropic hormone interactions
124. Prothoracicotropic hormone regulates phosphorylation of a specific protein in the prothoracic glands of the tobacco hornworm, Manduca sexta
125. Synthetic molecules designed as potential inhibitors in ecdysone biosynthesis
126. Regulation of insect steroid hormone synthesis by a MAP kinase
127. Changes in general and specific protein synthesis that accompany ecdysteroid synthesis in stimulated prothoracic glands of Manduca sexta
128. Prothoracicotropic hormone-regulated expression of a hsp70 cognate protein in the insect prothoracic gland
129. Prothoracicotropic hormone elicits a rapid, developmentally specific synthesis of β tubulin in an insect endocrine gland
130. Cloning of a β1 tubulin from an insect endocrine gland: Developmental and hormone-induced changes in mRNA expression
131. cDNA cloning and expression of a hormone-regulated heat shock protein (hsp70) from the prothoracic gland of Manduca sexta
132. Mediation of ecdysone synthesis in Manduca sexta by a hemolymph enzyme
133. Ecdysteroid synthesis and molting by the tobacco hornworm, Manduca sexta, in the absence of prothoracic glands
134. Shortloop negative and positive feedback on ecdysone secretion by prothoracic gland in the tobacco hornworm, Manduca sexta
135. 7-Dehydrosterols in prothoracic glands of the silkworm, Bombyx mori
136. Molecular characterization of prothoracicotropic hormone (PTTH) from the giant silkmoth Antheraea pernyi: Developmental appearance of PTTH-expressing cells and relationship to circadian clock cells in central brain
137. The position of the Arthropoda in the phylogenetic system
138. Synthesis and conversion study of a radiolabeled putative ecdysone precursor, 5β-cholest-7-ene-3β, 6α, 14α-triol in Locusta migratoria prothoracic glands
139. Proteins that bind to Drosophila chorion cis-regulatory elements: A new C2H2 zinc finger protein and a C2C2 steroid receptor-like component
140. Prothoracicotropic hormone is released five times in the 5th-larval instar of the silkworm, Bombyx mori
141. The carbachol-induced release of prothoracicotropic hormone from brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori
142. Mechanistic and metabolic studies of sterol 24,25-double bond reduction in Manduca sexta
143. The cholesterol side-chain cleavage system of the adrenal cortex: A mixed function oxidase
144. Involvement of cyclic AMP-dependent protein kinase in prothoracicotropic hormone-stimulated ecdysone synthesis
145. Cellular regulation of ecdysone synthesis by the prothoracic glands of Manduca sexta
146. The role of cyclic AMP in the regulation of ecdysone synthesis
147. Calcium-cyclic AMP interactions in prothoracicotropic hormone stimulation of ecdysone synthesis
148. Insulin receptor-like tyrosine kinase in the tobacco hornworm, Manduca sexta
149. Developmental changes in phosphodiesterase activity and hormonal response in the prothoracic glands of Manduca sexta
150. Cyclic AMP is a requisite messenger in the action of big PTTH in the prothoracic glands of pupal Manduca sexta
151. A diazepam binding inhibitor (DBI) homolog from the tobacco hornworm, Manduca sexta
152. Evidence for a diazepam-binding inhibitor (DBI) benzodiazepine receptor-like mechanism in ecdysteroidogenesis by the insect prothoracic gland
153. An immunophilin is a component of the insect ecdysone receptor (EcR) complex
154. S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: A role for S6 kinase
155. Multiple phosphorylation of ribosomal protein S6 and specific protein synthesis are required for prothoracicotropic hormone-stimulated ecdysteroid biosynthesis in the prothoracic glands of Manduca sexta
156. Alterations in Ultraspiracle (USP) content and phosphorylation state accompany feedback regulation of ecdysone synthesis in the insect prothoracic gland
157. Regulation of the acute production of steroids in steroidogenic cells
158. Variability of metabolism and function of sterols in insects
159. Metabolism of steroids in insects
160. The insect neuropeptide prothoracicotropic hormone is released with a daily rhythm: Re-evaluation of its role in development
161. Ecdysteroidogenic action of Bombyx prothoracicotropic hormone and bombyxin on the prothoracic glands of Rhodnius prolixus in vitro
162. The significance of moulting in Ecdysozoan evolution
163. Insect prothoracic glands: A role for cyclic AMP in the stimulation of ecdysone secretion
164. 1 mutation
165. Can the insect nervous system synthesize ecdysteroids?
166. Ecdysone metabolism and distribution during the pupal-adult development of Manduca sexta
167. Metabolism in vitro of cholesterol and 25-hydroxycholesterol by the larval prothoracic glands of Manduca sexta
168. Ecdysone biosynthesis: Pathways, enzymes and the early steps problem
169. Stereospecific, mechanism-based, suicide inhibition of a cytochrome P450 involved in ecdysteroid biosynthesis in the prothoracic glands of Manduca sexta
170. Synthesis and secretion in vitro of ecdysteroids by the prothoracic glands of Manduca sexta
171. Regulation of the ecdysteroid titer of Manduca sexta: Reappraisal of the role of the prothoracic glands
172. Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster
173. Involvement of microtubules in prothoracicotropic hormone-stimulated ecdysteroidogenesis by insect (Manduca sexta) prothoracic glands
174. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the X-chromosome and fourth chromosome
175. Characterization of ecdysteroid 26-hydroxylase: An enzyme involved in molting hormone inactivation
176. Cloning of a cDNA encoding a novel cytochrome P450 from the insect Locusta migratoria: CYP6H1, a putative ecdysone 20-hydroxylase
177. rgl) causes ecdysteroid deficiency in the third instar of Drosophila melanogaster
178. Functional ecdysone receptor is the product of EcR and ultraspiracle genes
179. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting
180. A novel member of the bombyxin gene family: Structure and expression of bombyxin G1 gene, an insulin-related peptide gene of the silkmoth Bombyx mori