Chronic lymphocytic leukaemia: An immunobiology approach

Srpski Arhiv za Celokupno Lekarstvo

Volumn 136, Issue 5-6, 2008, Pages 319-323

  Kostareli, Efterpi ^a   Smilevska, Tatjana ^a   Stamatopoulos, Kostas ^a   Kouvatsi, Anastasia ^b   Anagnostopoulos, Achilles ^a  

^a G PAPANICOLAOU HOSPITAL   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Chronic lymphocytic leukaemia; Clinical characterististics; Immunoglobulin repertoire; Molecular genetic aspects

Indexed keywords

IMMUNOGLOBULIN;

B CELL LEUKEMIA; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGY; REVIEW;

GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL;

EID: 53049107932     PISSN: 03708179     EISSN: None     Source Type: Journal    
DOI: 10.2298/SARH0806319K     Document Type: Article

References (57)

1. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005; 352:804-15.
2. Dighiero G. CLL biology and prognosis. hematology. Am Soc Hematol Educ Program 2005; 278-84.
3. Damle RN, Wasil T, Fais F, et al. IgV gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94:1840-7.
4. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94:1848-54.
5. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343:1910-6.
6. Ghia P, Stamatopoulos K, Belessi C, et al. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105:1678-85.
7. Stamatopoulos K, Belessi C, Hadzidimitriou A, et al. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood 2005; 106:3575-83.
8. Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival inchronic lymphocytic leukemia. Blood 2002; 100:1410-6.
9. Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351:893-901.
10. Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 2003; 21:841-94.
11. Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 2004; 103:4389-95.
12. Oppezzo P, Dighiero G. What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis? Curr Top Microbiol Immunol 2005; 294:71-89.
13. Maizels N. Immunoglobulin gene diversification. Annu Rev Genet 2005; 39:23-46.
14. Schlissel MS. Regulating antigen-receptor gene assembly. Nat Rev Immunol 2003; 3:890-9.
15. Lefranc M-P. Nomenclature of the human immunoglobulin heavy (IGH) genes. Exp Clin Immunogenet 2001; 18:100-16.
16. Lefranc M-P. Nomenclature of the human immunoglobulin kappa (IGK) genes. Exp Clin Immunogenet 2001; 18:161-74.
17. Lefranc M-P. Nomenclature of the human immunoglobulin lambda (IGL) genes. Exp Clin Immunogenet 2001; 18:242-54.
18. Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol 2005; 86:43-112.
19. Papavasiliou F, Casellas R, Suh H, et al. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 1997; 278:298-301.
20. Brauninger A, Goossens T, Rajewsky K, Kuppers R. Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. Eur J Immunol 2001; 31:3631-7.
21. Papavasiliou FN, Schatz DG. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 2002; 109:S35-44.
22. Besmer E, Gourzi P, Papavasiliou FN. The regulation of somatic hypermutation. Curr Opin Immunol 2004; 16:241-5.
23. Seki M, Gearhart PJ, Wood RD. DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO Rep 2005; 6:1143-8.
24. Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol 2005; 5:171-8.
25. Di Noia JM, Neuberger MS. Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 2007; 76:1-22.
26. Manser T. Textbook germinal centers? J Immunol 2004; 172:3369-75.
27. William J, Euler C, Christensen S, Schlomchik M. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002; 297(5589):2006-8.
28. Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC, Wardemann H. Autoreactivity in human IgG+ memory B cells. Immunity 2007; 26:205-13.
29. Kenter AL. Class switch recombination: an emerging mechanism. Curr Top Microbiol Immunol 2005; 290:171-99.
30. Selsing E. Ig class switching: targeting the recombinational mechanism. Curr Opin Immunol 2006; 18:249-54.
31. Pan-Hammarstrom Q, Zhao Y, Hammarstrom L. Class switch recombination: a comparison between mouse and human. Adv Immunol 2007; 93:1-61.
32. Montserrat E. Classical and new prognostic factors in chronic lymphocytic leukemia: where to now? Hematol J 2002; 3:7-9.
33. Maloum K, Davi F, Merle-Beral H, et al. Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia. Blood 2000; 96:377-9.
34. Forconi F, Sahota SS, Lauria F, Stevenson FK. Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated? Leukemia 2004; 18:882-3.
35. Vasconcelos Y, Davi F, Levy V, et al. Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia. J Clin Oncol 2003; 21:3928-32.
36. Ghia P, Guida G, Stella S, et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2002; 101:1262-9.
37. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348:1764-75.
38. Oscier DG, Gardiner AC, Mould SJ, et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood 2002; 100:1177-84.
39. Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102:1515-25.
40. Binet JL, Caligaris-Cappio F, Catovsky D, et al; International Workshop on Chronic Lymphocytic Leukemia (IWCLL). Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood 2006; 107:859-61.
41. Damle R, Allen S, Rai K, Chiorazzi N. CD38 Expression identifies an active subset of proliferating cells within the clonal population in chronic lymphocytic leukemia patients (in vitro analysis). Blood (ASH Annual Meeting Abstracts) 2006; 108:Abstract 28.
42. Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001; 194:1625-38.
43. Brezinschek HP, Foster SJ, Dorner T, Brezinschek RI, Lipsky PE. Pairing of variable heavy and variable kappa chains in individual naive and memory B cells. J Immunol 1998; 160:4762-7.
44. de Wildt RM, Hoet RM, van Venrooij WJ, Tomlinson IM, Winter G. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J Mol Biol 1999; 285:895-901.
45. Xu JL, Davis MM. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 2000; 13(1):37-45.
46. Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997; 158:235-46.
47. Widhopf GF 2nd, Kipps TJ. Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. J Immunol 2001; 166:95-102.
48. Tobin G, Thunberg U, Johnson A, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003; 101:4952-7.
49. Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004; 113:1008-16.
50. Widhopf GF 2nd, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104:2499-504.
51. Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004; 200:519-25.
52. Tobin G, Thunberg U, Karlsson K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104:2879-85.
53. Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3- 21-utilizing chronic lymphocytic leukemia independent of geographical origin and mutational status. Blood 2006; 107:2889-94.
54. Belessi CJ, Davi FB, Stamatopoulos KE, et al. IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors. Eur J Immunol 2006; 36:1963-74.
55. Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood 2007; 109:259-70.
56. Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood 2003; 10:1087-93.
57. Vuillier F, Dumas G, Magnac C, et al. Lower levels of surface B-cellreceptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains. Blood 2005; 105:2933-40.