Pairing of variable heavy and variable κ chains in individual naive and memory B cells

Journal of Immunology

Volumn 160, Issue 10, 1998, Pages 4762-4767

  Brezinschek, Hans Peter ^a   Foster, Sandra J ^a   Dörner, Thomas ^a   Brezinschek, Ruth I ^a   Lipsky, Peter E ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M ANTIBODY;

ADULT; AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE ACTIVATION; CASE REPORT; GENE REARRANGEMENT; HUMAN; MALE; MEMORY CELL; MUTATION RATE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADULT; B-LYMPHOCYTES; GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED;

EID: 0032525035     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. French, D. L., R. Laskov, and M. D. Scharf. 1989. The role of somatic hypermutation in the generation of antibody diversity. Science 244;1152.
2. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
3. Berek, C. A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
4. Roben, P., S. M. Barbas, L. Sandoval, J.-M. Lecerf, B. D. Stollar, A. Solomon, and G. J. Silverman. 1996. Repertoire cloning of lupus anti-DNA autoantibodies. J. Clin. Invest. 98:2827.
5. Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
6. + B cells. J. Clin. Invest. 99:2488.
7. + B cells. J. Clin. Invest. 99:1614.
8. Tomlinson, I. M., S. C. Williams, S. J. Corbett, J. B. L. Cox, and G. Winter. 1996. V BASE sequence directory. MRC Centre for Protein Engineering, Cambridge, U.K.
9. Kirkwood, B. R. 1988. In Essentials of Medical Statistics. Blackwell Scientific Publications, Oxford, p. 57.
10. Zheng, B., G. Kelsoe, and S. Han. 1996. Somatic diversification of antibody responses. J. Clin. Immunol. 16:1.
11. H CDR3. Proc. Natl. Acad. Sci. USA 94:9637.
12. Raaphorst, F. M., C. S. Raman, B. T. Nall, and J. M. Teale. 1997. Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes. Immunol. Today 18:37.
13. Neuberger, M. S., and C. Milstein. 1995. Somatic hypermutation. Curr. Opin. Immunol. 7:248.
14. Storb, U., A. Peters, E. Klotz, B. Rogerson, and J. Hackett, Jr. 1996. The mechanism of somatic hypermutation studied with transgenic and transfectcd target genes. Semin. Immunol. 8:131.
15. Tumas-Brundage, K., and T. Manser. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185:239.
16. Dörner, T., H. P. Brezinschek, R. I. Brezinschek, S. J. Foster, R. Domiati-Saad, and P. E. Lipsky. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immunol. 158:2779.
17. Cockerill, P. N., M.-H. Yuen, and W. T. Garrad. 1987. The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements. J. Biol. Chem. 262:5394.
18. Forrester, W. C., C. van Genderen, T. Jenuwein, and R. Grosschedl. 1994. Dependence of enhancer-mediated transcription of the immunoglobulin M gene on nuclear matrix attachment regions. Science 265:1221.
19. Xu, M., R. E. Hammer, V. C. Blasquez, S. L. Jones, and W. T. Garrad. 1989. Immunoglobulin κ gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice. J. Biol. Chem. 264:21190.
20. Betz, A. G., C. Milstein, A. Gonzalez-Fernandez, R. Pannell, T. Larsson, and M. S. Neuberger. 1994. Elements regulating somatic hype mutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
21. Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57.
22. Klotz, E. L., and U. Storb. 1996. Somatic hypermutation of a λ 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer. J. Immunol. 157:4458.
23. Storb, U. 1996. The molecular basis of somatic hypermutation of immunoglobulin genes. Curr. Opin. Immunol. 8:206.
24. Kranz, D. M., and E. W. Voss, Jr. 1981. Restricted reassociation of heavy and light chains from hap ten-specific monoclonal antibodies. Proc. Natl. Acad. Sci. USA 78:5807.
25. Mosmann, T. R., and A. R. Williamson. 1980. Structural mutations in a mouse immunoglobulin light chain resulting in failure to be secreted. Cell 20:283.
26. Winberry, L., A. Marks, and R. Baumal. 1980. Immunoglobulin production and secretion by variant clones of the MOPC 315 mouse myeloma cell line. J. Immunol. 124:1174.
27. Dul, J. L., and Y. Argon. 1990. A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion. Proc. Natl. Acad. Sci. USA 87:8135.
28. Dul, J. L., O. R. Burrone, and Y. Argon. 1992. A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine. J. Immunol. 149:1927.
29. Chen, C. T. M. Martin, S. Stevens, and T. M. Rittenberg. 1994. Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2. J. Exp. Med. 180:577.
30. Martin, T. M., C. Kowalczyk, S. Stevens, G. D. Wiens, M. P. Stenzel-Poore, and M. B. Rittenberg. 1996. Deletion in HCDR3 rescues T15 antibody mutants from a secretion defect caused by mutations in HCDR2. J. Immunol. 157:4341.
31. Radic, M. Z., and M. Zouali. 1996. Receptor editing, immune diversification, and self-tolerance. Immunity 5:505.