Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire

Journal of Molecular Biology

Volumn 285, Issue 3, 1999, Pages 895-901

  De Wildt, Ruud M T ^a   Hoet, René M A ^a   Van Venrooij, Walther J ^a   Tomlinson, Ian M ^b   Winter, Greg ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Heavy and light chain pairings; Receptor editing; Secondary light chain rearrangement; Somatic hypermutation

Indexed keywords

ANTIBODY; CELL RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; EVOLUTION; GENE MUTATION; HUMAN; HUMAN CELL; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; SOMATIC MUTATION;

EID: 0033593356     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2396     Document Type: Article

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