Structure and mechanism of the rebeccamycin sugar 4′-O- methyltransferase RebM

Journal of Biological Chemistry

Volumn 283, Issue 33, 2008, Pages 22628-22636

  Singh, Shanteri ^a   McCoy, Jason G ^a   Zhang, Changsheng ^a   Bingman, Craig A ^a   Phillips Jr , George N ^a   Thorson, Jon S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; HYDROPHOBICITY; SUGAR (SUCROSE); SUGARS;

APPLICATIONS.; CATALYTIC RESIDUES; DIMERIZATION DOMAINS; HOMOCYSTEINE; HYDROPHOBIC INTERACTIONS; INDOLOCARBAZOLE; METHYL TRANSFERASES; NATURAL PRODUCTS; REBECCAMYCIN; SMALL MOLECULES; SUBSTRATE BINDING MODELS;

CRYSTAL STRUCTURE;

ASPARTIC ACID; CARBAZOLE DERIVATIVE; HISTIDINE; INDOLE DERIVATIVE; REBECCAMYCIN; SUGAR 4' O METHYLTRANSFERASE REBM; UNCLASSIFIED DRUG; METHYLTRANSFERASE; REBECCAMYCIN 4' O METHYLTRANSFERASE, LECHEVALIERIA AEROCOLONIGENES; REBECCAMYCIN 4'-O-METHYLTRANSFERASE, LECHEVALIERIA AEROCOLONIGENES; RECOMBINANT PROTEIN; S ADENOSYLHOMOCYSTEINE; STAUROSPORINE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; METHYLATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; CRYSTALLIZATION; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CARBAZOLES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; S-ADENOSYLHOMOCYSTEINE; STAUROSPORINE;

EID: 53049087315     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800503200     Document Type: Article

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