Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD

Biochemistry

Volumn 44, Issue 48, 2005, Pages 15652-15663

  Howard Jones, Annaleise R ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; MOLECULAR STRUCTURE; NITROGEN COMPOUNDS;

CHROMOPYRROLIC ACID; ENZYMATIC GENERATION; L-TRYPTOPHAN; TWO-ELECTRON OXIDATION;

CARBOXYLIC ACIDS;

CARBAZOLE DERIVATIVE; CATALASE; CHROMOPYRROLIC ACID; CHROMOPYRROLIC ACID SYNTHASE; FLAVOPROTEIN; HEME; IMINE; INDOLE DERIVATIVE; INDOLEPYRUVIC ACID; OXIDOREDUCTASE; OXYGEN; PROTEIN REBD; PROTEIN REBO; PYRROLE DERIVATIVE; REBECCAMYCIN; STAUROSPORINE DERIVATIVE; SYNTHETASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS;

AMINO ACID OXIDOREDUCTASES; CARBAZOLES; ENZYME ACTIVATION; ENZYMES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; INDOLES; MASS SPECTROMETRY;

ESCHERICHIA COLI;

EID: 28544449005     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051706e     Document Type: Article

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