Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid

Journal of the American Chemical Society

Volumn 128, Issue 37, 2006, Pages 12289-12298

  Howard Jones, Annaleise R ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CATALYSIS; CONDENSATION; ENZYME KINETICS; ESCHERICHIA COLI; GENES; ONCOLOGY; ORGANIC ACIDS; OXIDATION;

AGLYCONES; CYTOCHROME; DECARBOXYLATION; STREPTOMYCETES;

DRUG PRODUCTS;

1,11 DICHLOROARCYRIAFLAVIN A; AGLYCONE; ARCYRIAFLAVIN A; CARBAZOLE DERIVATIVE; CYTOCHROME P450; FERREDOXIN; FLAVODOXIN; INDOLE DERIVATIVE; K 252C; MALEIMIDE; OXYGEN; OXYGEN 18; PROTEIN; PROTEIN REBC; PROTEIN STAC; PROTEIN STAP; REBECCAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; STAUROSPORINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; BIOSYNTHESIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ESCHERICHIA COLI; ISOTOPE LABELING; NONHUMAN; POLYMERIZATION; PROTEIN EXPRESSION; STREPTOMYCETACEAE; STRUCTURE ANALYSIS;

CARBAZOLES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; FLAVIN-ADENINE DINUCLEOTIDE; INDOLES; KINETICS; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; NAD; OXIDATION-REDUCTION; OXYGEN ISOTOPES; RECOMBINANT PROTEINS; STAUROSPORINE; STREPTOMYCETACEAE;

EID: 33748758449     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja063898m     Document Type: Article

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