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Volumn 74, Issue 4, 2008, Pages 316-324

Promoting ectopic pancreatic fates: Pancreas development and future diabetes therapies

Author keywords

Cell replacement therapy; Ngn3; Pancreas; Pdx1; Ptf1a; Stem cells; Transdifferentiation; Xenopus zebrafish

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HOMEODOMAIN PROTEIN; NEOGENIN; PROTEIN ARX; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR PTF1A; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 52449134197     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2008.01081.x     Document Type: Review
Times cited : (10)

References (98)
  • 1
    • 0000197284 scopus 로고
    • Pancreatic extracts in the treatment of diabetes mellitus: Preliminary report
    • Banting FG, Best CH, Collip JB et al. Pancreatic extracts in the treatment of diabetes mellitus: Preliminary report. Can Med Assoc J 1922: 12: 141-146.
    • (1922) Can Med Assoc J , vol.12 , pp. 141-146
    • Banting, F.G.1    Best, C.H.2    Collip, J.B.3
  • 2
    • 0348047628 scopus 로고    scopus 로고
    • Gene regulatory factors in pancreatic development
    • Jensen J. Gene regulatory factors in pancreatic development. Dev Dyn 2004: 229: 176-200.
    • (2004) Dev Dyn , vol.229 , pp. 176-200
    • Jensen, J.1
  • 3
    • 33847402673 scopus 로고    scopus 로고
    • Pancreas and beta-cell development: From the actual to the possible
    • Murtaugh LC. Pancreas and beta-cell development: From the actual to the possible. Development 2007: 134: 427-438.
    • (2007) Development , vol.134 , pp. 427-438
    • Murtaugh, L.C.1
  • 5
    • 0033853143 scopus 로고    scopus 로고
    • Development of the pancreas in Xenopus laevis
    • Kelly OG, Melton DA. Development of the pancreas in Xenopus laevis. Dev Dyn 2000: 218: 615-627.
    • (2000) Dev Dyn , vol.218 , pp. 615-627
    • Kelly, O.G.1    Melton, D.A.2
  • 6
    • 35349020015 scopus 로고    scopus 로고
    • An illustrated review of early pancreas development in the mouse
    • Jorgensen MC, Ahnfelt-Ronne J, Hald J et al. An illustrated review of early pancreas development in the mouse. Endocr Rev 2007: 28: 685-705.
    • (2007) Endocr Rev , vol.28 , pp. 685-705
    • Jorgensen, M.C.1    Ahnfelt-Ronne, J.2    Hald, J.3
  • 7
    • 0037213654 scopus 로고    scopus 로고
    • From endoderm formation to liver and pancreas development in zebrafish
    • Ober EA, Field HA, Stainier DY. From endoderm formation to liver and pancreas development in zebrafish. MechDev 2003: 120: 5-18.
    • (2003) MechDev , vol.120 , pp. 5-18
    • Ober, E.A.1    Field, H.A.2    Stainier, D.Y.3
  • 8
    • 16544378027 scopus 로고    scopus 로고
    • Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas
    • Lin JW, Biankin AV, Horb ME et al. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol 2004: 274: 491-503.
    • (2004) Dev Biol , vol.274 , pp. 491-503
    • Lin, J.W.1    Biankin, A.V.2    Horb, M.E.3
  • 9
    • 34047181476 scopus 로고    scopus 로고
    • Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas
    • Jarikji ZH, Vanamala S, Beck CW et al. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev Biol 2007: 304: 786-799.
    • (2007) Dev Biol , vol.304 , pp. 786-799
    • Jarikji, Z.H.1    Vanamala, S.2    Beck, C.W.3
  • 10
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion of liver to pancreas
    • Horb ME, Shen CN, Tosh D et al. Experimental conversion of liver to pancreas. Curr Biol 2003: 13: 105-115.
    • (2003) Curr Biol , vol.13 , pp. 105-115
    • Horb, M.E.1    Shen, C.N.2    Tosh, D.3
  • 11
    • 0041508755 scopus 로고    scopus 로고
    • Formation of the digestive system in zebrafish. II. Pancreas morphogenesis
    • Field HA, Dong PD, Beis D et al. Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev Biol 2003: 261: 197-208.
    • (2003) Dev Biol , vol.261 , pp. 197-208
    • Field, H.A.1    Dong, P.D.2    Beis, D.3
  • 12
    • 33644746214 scopus 로고    scopus 로고
    • Germ layers to organs: Using Xenopus to study "later"development
    • Blitz IL, Andelfinger G, Horb ME. Germ layers to organs: Using Xenopus to study "later"development. SeminCell Dev Biol 2006: 17: 133-145.
    • (2006) SeminCell Dev Biol , vol.17 , pp. 133-145
    • Blitz, I.L.1    Andelfinger, G.2    Horb, M.E.3
  • 13
    • 33744814639 scopus 로고    scopus 로고
    • Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue
    • Afelik S, Chen Y, Pieler T. Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. Genes Dev 2006: 20: 1441-1446.
    • (2006) Genes Dev , vol.20 , pp. 1441-1446
    • Afelik, S.1    Chen, Y.2    Pieler, T.3
  • 14
    • 0024471574 scopus 로고
    • XlHbox 8: A novel Xenopus homeo protein restricted to a narrow band of endoderm
    • Wright CV, Schnegelsberg P, De Robertis EM. XlHbox 8: A novel Xenopus homeo protein restricted to a narrow band of endoderm. Development 1989: 105: 787-794.
    • (1989) Development , vol.105 , pp. 787-794
    • Wright, C.V.1    Schnegelsberg, P.2    De Robertis, E.M.3
  • 15
    • 0027373441 scopus 로고
    • Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    • Leonard J, Peers B, Johnson T et al. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 1993: 7: 1275-1283.
    • (1993) Mol Endocrinol , vol.7 , pp. 1275-1283
    • Leonard, J.1    Peers, B.2    Johnson, T.3
  • 16
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K, Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 1993: 12: 4251-4259.
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 17
    • 0028314969 scopus 로고
    • IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
    • Miller CP, McGehee RE Jr, Habener JF. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 1994: 13: 1145-1156.
    • (1994) EMBO J , vol.13 , pp. 1145-1156
    • Miller, C.P.1    McGehee Jr., R.E.2    Habener, J.F.3
  • 18
    • 0028206319 scopus 로고
    • XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor
    • Peshavaria M, Gamer L, Henderson E et al. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol 1994: 8: 806-816.
    • (1994) Mol Endocrinol , vol.8 , pp. 806-816
    • Peshavaria, M.1    Gamer, L.2    Henderson, E.3
  • 19
    • 0033960256 scopus 로고    scopus 로고
    • Early pattern of differentiation in the human pancreas
    • Polak M, Bouchareb-Banaei L, Scharfmann R et al. Early pattern of differentiation in the human pancreas. Diabetes 2000: 49: 225-232.
    • (2000) Diabetes , vol.49 , pp. 225-232
    • Polak, M.1    Bouchareb-Banaei, L.2    Scharfmann, R.3
  • 20
    • 41649118494 scopus 로고    scopus 로고
    • The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm
    • Spagnoli FM, Brivanlou AH. The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. Development 2008: 135: 451-461.
    • (2008) Development , vol.135 , pp. 451-461
    • Spagnoli, F.M.1    Brivanlou, A.H.2
  • 21
    • 34347341779 scopus 로고    scopus 로고
    • Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development
    • McLin VA, Rankin SA, Zorn AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007: 134: 2207-2217.
    • (2007) Development , vol.134 , pp. 2207-2217
    • McLin, V.A.1    Rankin, S.A.2    Zorn, A.M.3
  • 22
    • 5744240610 scopus 로고    scopus 로고
    • A conserved role for retinoid signaling in vertebrate pancreas development
    • Stafford D, Hornbruch A, Mueller PR et al. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol 2004: 214: 432-441.
    • (2004) Dev Genes Evol , vol.214 , pp. 432-441
    • Stafford, D.1    Hornbruch, A.2    Mueller, P.R.3
  • 23
    • 0034544776 scopus 로고    scopus 로고
    • In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid
    • Moriya N, Komazaki S, Takahashi S et al. In vitro pancreas formation from Xenopus ectoderm treated with activin and retinoic acid. Dev Growth Differ 2000: 42: 593-602.
    • (2000) Dev Growth Differ , vol.42 , pp. 593-602
    • Moriya, N.1    Komazaki, S.2    Takahashi, S.3
  • 24
    • 16244406880 scopus 로고    scopus 로고
    • Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
    • Molotkov A, Molotkova N, Duester G. Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 2005: 232: 950-957.
    • (2005) Dev Dyn , vol.232 , pp. 950-957
    • Molotkov, A.1    Molotkova, N.2    Duester, G.3
  • 25
    • 23944453381 scopus 로고    scopus 로고
    • Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    • Martin M, Gallego-Llamas J, Ribes V et al. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 2005: 284: 399-411.
    • (2005) Dev Biol , vol.284 , pp. 399-411
    • Martin, M.1    Gallego-Llamas, J.2    Ribes, V.3
  • 26
    • 35648977027 scopus 로고    scopus 로고
    • Hedgehog signaling in development and homeostasis of the gastrointestinal tract
    • van den Brink GR. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 2007: 87: 1343-1375.
    • (2007) Physiol Rev , vol.87 , pp. 1343-1375
    • van den Brink, G.R.1
  • 27
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development
    • Hebrok M. Hedgehog signaling in pancreas development. Mech Dev 2003: 120: 45-57.
    • (2003) Mech Dev , vol.120 , pp. 45-57
    • Hebrok, M.1
  • 28
    • 34547326050 scopus 로고    scopus 로고
    • Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms
    • Pan FC, Chen Y, Bayha E et al. Retinoic acid-mediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms. Mech Dev 2007: 124: 518-531.
    • (2007) Mech Dev , vol.124 , pp. 518-531
    • Pan, F.C.1    Chen, Y.2    Bayha, E.3
  • 29
    • 2942542776 scopus 로고    scopus 로고
    • Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
    • Chen Y, Pan FC, Brandes N et al. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 2004: 271: 144-160.
    • (2004) Dev Biol , vol.271 , pp. 144-160
    • Chen, Y.1    Pan, F.C.2    Brandes, N.3
  • 30
    • 0035174595 scopus 로고    scopus 로고
    • Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus
    • Zhang J, Rosenthal A, de Sauvage FJ et al. Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol 2001: 229: 188-202.
    • (2001) Dev Biol , vol.229 , pp. 188-202
    • Zhang, J.1    Rosenthal, A.2    de Sauvage, F.J.3
  • 31
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998: 12: 1705-1713.
    • (1998) Genes Dev , vol.12 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 32
    • 0035806957 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
    • Roy S, Qiao T, Wolff C et al. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr Biol 2001: 11: 1358-1363.
    • (2001) Curr Biol , vol.11 , pp. 1358-1363
    • Roy, S.1    Qiao, T.2    Wolff, C.3
  • 33
    • 0036534809 scopus 로고    scopus 로고
    • Sonic hedgehog is required early in pancreatic islet development
    • diIorio PJ, Moss JB, Sbrogna JL et al. Sonic hedgehog is required early in pancreatic islet development. Dev Biol 2002: 244: 75-84.
    • (2002) Dev Biol , vol.244 , pp. 75-84
    • diIorio, P.J.1    Moss, J.B.2    Sbrogna, J.L.3
  • 34
    • 41849093727 scopus 로고    scopus 로고
    • Intra-endodermal interactions are required for pancreatic beta cell induction
    • Chung WS, Stainier DY. Intra-endodermal interactions are required for pancreatic beta cell induction. Dev Cell 2008: 14: 582-593.
    • (2008) Dev Cell , vol.14 , pp. 582-593
    • Chung, W.S.1    Stainier, D.Y.2
  • 35
    • 0038360823 scopus 로고    scopus 로고
    • The onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    • Jacquemin P, Lemaigre FP, Rousseau GG. The onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol 2003: 258: 105-116.
    • (2003) Dev Biol , vol.258 , pp. 105-116
    • Jacquemin, P.1    Lemaigre, F.P.2    Rousseau, G.G.3
  • 36
    • 19244372001 scopus 로고    scopus 로고
    • Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
    • Jacquemin P, Durviaux SM, Jensen J et al. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 2000: 20: 4445-4454.
    • (2000) Mol Cell Biol , vol.20 , pp. 4445-4454
    • Jacquemin, P.1    Durviaux, S.M.2    Jensen, J.3
  • 37
    • 0029868156 scopus 로고    scopus 로고
    • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    • Offield MF, Jetton TL, Labosky PA et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996: 122: 983-995.
    • (1996) Development , vol.122 , pp. 983-995
    • Offield, M.F.1    Jetton, T.L.2    Labosky, P.A.3
  • 38
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T et al. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994: 371: 606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3
  • 39
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren U, Jonsson J, Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/ PDX1-deficient mice. Development 1996: 122: 1409-1416.
    • (1996) Development , vol.122 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 40
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers DA, Zinkin NT, Stanojevic V et al. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997: 15: 106-110.
    • (1997) Nat Genet , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3
  • 41
    • 0141787919 scopus 로고    scopus 로고
    • Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
    • Schwitzgebel VM, Mamin A, Brun T et al. Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab 2003: 88: 4398-4406.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4398-4406
    • Schwitzgebel, V.M.1    Mamin, A.2    Brun, T.3
  • 42
    • 0034903133 scopus 로고    scopus 로고
    • Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell
    • Yee NS, Yusuff S, Pack M. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis 2001: 30: 137-140.
    • (2001) Genesis , vol.30 , pp. 137-140
    • Yee, N.S.1    Yusuff, S.2    Pack, M.3
  • 43
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y, Cooper B, Gannon M et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002: 32: 128-134.
    • (2002) Nat Genet , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3
  • 44
    • 0032417268 scopus 로고    scopus 로고
    • The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
    • Krapp A, Knofler M, Ledermann B et al. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 1998: 12: 3752-3763.
    • (1998) Genes Dev , vol.12 , pp. 3752-3763
    • Krapp, A.1    Knofler, M.2    Ledermann, B.3
  • 45
    • 34347345036 scopus 로고    scopus 로고
    • Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression
    • Wiebe PO, Kormish JD, Roper VT et al. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Molecular and cellular biology 2007: 27: 4093-4104.
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 4093-4104
    • Wiebe, P.O.1    Kormish, J.D.2    Roper, V.T.3
  • 46
    • 40949099880 scopus 로고    scopus 로고
    • Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells
    • Burlison JS, Long Q, Fujitani Y et al. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol 2008: 316: 74-86.
    • (2008) Dev Biol , vol.316 , pp. 74-86
    • Burlison, J.S.1    Long, Q.2    Fujitani, Y.3
  • 47
    • 35348985382 scopus 로고    scopus 로고
    • Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
    • Masui T, Long Q, Beres TM et al. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev 2007: 21: 2629-2643.
    • (2007) Genes Dev , vol.21 , pp. 2629-2643
    • Masui, T.1    Long, Q.2    Beres, T.M.3
  • 48
    • 1642287386 scopus 로고    scopus 로고
    • Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates
    • Zecchin E, Mavropoulos A, Devos N et al. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Dev Biol 2004: 268: 174-184.
    • (2004) Dev Biol , vol.268 , pp. 174-184
    • Zecchin, E.1    Mavropoulos, A.2    Devos, N.3
  • 49
    • 9644255692 scopus 로고    scopus 로고
    • Mutations in PTF1A cause pancreatic and cerebellar agenesis
    • Sellick GS, Barker KT, Stolte-Dijkstra I et al. Mutations in PTF1A cause pancreatic and cerebellar agenesis. Nat Genet 2004: 36: 1301-1305.
    • (2004) Nat Genet , vol.36 , pp. 1301-1305
    • Sellick, G.S.1    Barker, K.T.2    Stolte-Dijkstra, I.3
  • 50
    • 33845957180 scopus 로고    scopus 로고
    • Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach
    • Fodor A, Harel C, Fodor L et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach. Diabetologia 2007: 50: 121-130.
    • (2007) Diabetologia , vol.50 , pp. 121-130
    • Fodor, A.1    Harel, C.2    Fodor, L.3
  • 51
    • 34548782660 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/ enhancer-binding protein beta
    • Meivar-Levy I, Sapir T, Gefen-Halevi S et al. Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta. Hepatology 2007: 46: 898-905.
    • (2007) Hepatology , vol.46 , pp. 898-905
    • Meivar-Levy, I.1    Sapir, T.2    Gefen-Halevi, S.3
  • 52
    • 34247597744 scopus 로고    scopus 로고
    • Ectopic PDX-1 expression in liver ameliorates type 1 diabetes
    • Shternhall-Ron K, Quintana FJ, Perl S et al. Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. J Autoimmun 2007: 28: 134-142.
    • (2007) J Autoimmun , vol.28 , pp. 134-142
    • Shternhall-Ron, K.1    Quintana, F.J.2    Perl, S.3
  • 53
    • 33744813002 scopus 로고    scopus 로고
    • Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
    • Miyatsuka T, Kaneto H, Shiraiwa T et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev 2006: 20: 1435-1440.
    • (2006) Genes Dev , vol.20 , pp. 1435-1440
    • Miyatsuka, T.1    Kaneto, H.2    Shiraiwa, T.3
  • 54
    • 33745214464 scopus 로고    scopus 로고
    • Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
    • Fukuda A, Kawaguchi Y, Furuyama K et al. Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest 2006: 116: 1484-1493.
    • (2006) J Clin Invest , vol.116 , pp. 1484-1493
    • Fukuda, A.1    Kawaguchi, Y.2    Furuyama, K.3
  • 55
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002: 129: 2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 56
    • 4444277786 scopus 로고    scopus 로고
    • Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
    • Esni F, Ghosh B, Biankin AV et al. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development 2004: 131: 4213-4224.
    • (2004) Development , vol.131 , pp. 4213-4224
    • Esni, F.1    Ghosh, B.2    Biankin, A.V.3
  • 57
    • 33846910410 scopus 로고    scopus 로고
    • SOX9 is required for maintenance of the pancreatic progenitor cell pool
    • Seymour PA, Freude KK, Tran MN et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A 2007: 104: 1865-1870.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 1865-1870
    • Seymour, P.A.1    Freude, K.K.2    Tran, M.N.3
  • 58
    • 34547525676 scopus 로고    scopus 로고
    • Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    • Lynn FC, Smith SB, Wilson ME et al. Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci U S A 2007: 104: 10500-10505.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10500-10505
    • Lynn, F.C.1    Smith, S.B.2    Wilson, M.E.3
  • 59
    • 0033825383 scopus 로고    scopus 로고
    • Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    • Schwitzgebel VM, Scheel DW, Conners JR et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000: 127: 3533-3542.
    • (2000) Development , vol.127 , pp. 3533-3542
    • Schwitzgebel, V.M.1    Scheel, D.W.2    Conners, J.R.3
  • 60
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M et al. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 2000: 97: 1607-1611.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3
  • 61
    • 33645281942 scopus 로고    scopus 로고
    • IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
    • Mellitzer G, Bonne S, Luco RF et al. IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J 2006: 25: 1344-1352.
    • (2006) EMBO J , vol.25 , pp. 1344-1352
    • Mellitzer, G.1    Bonne, S.2    Luco, R.F.3
  • 62
    • 33748251457 scopus 로고    scopus 로고
    • The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
    • Gierl MS, Karoulias N, Wende H et al. The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev 2006: 20: 2465-2478.
    • (2006) Genes Dev , vol.20 , pp. 2465-2478
    • Gierl, M.S.1    Karoulias, N.2    Wende, H.3
  • 63
    • 0033606972 scopus 로고    scopus 로고
    • Notch signalling controls pancreatic cell differentiation
    • Apelqvist A, Li H, Sommer L et al. Notch signalling controls pancreatic cell differentiation. Nature 1999: 400: 877-881.
    • (1999) Nature , vol.400 , pp. 877-881
    • Apelqvist, A.1    Li, H.2    Sommer, L.3
  • 64
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson KA, Dursun U, Jordan N et al. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 2007: 12: 457-465.
    • (2007) Dev Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3
  • 65
    • 0142091542 scopus 로고    scopus 로고
    • Opposing actions of Arx and Pax4 in endocrine pancreas development
    • Collombat P, Mansouri A, Hecksher-Sorensen J et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev 2003: 17: 2591-2603.
    • (2003) Genes Dev , vol.17 , pp. 2591-2603
    • Collombat, P.1    Mansouri, A.2    Hecksher-Sorensen, J.3
  • 66
    • 34147092649 scopus 로고    scopus 로고
    • Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    • Collombat P, Hecksher-Sorensen J, Krull J et al. Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest 2007: 117: 961-970.
    • (2007) J Clin Invest , vol.117 , pp. 961-970
    • Collombat, P.1    Hecksher-Sorensen, J.2    Krull, J.3
  • 67
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    • Sosa-Pineda B, Chowdhury K, Torres M et al. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 1997: 386: 399-402.
    • (1997) Nature , vol.386 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3
  • 68
    • 23144432613 scopus 로고    scopus 로고
    • The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    • Collombat P, Hecksher-Sorensen J, Broccoli V et al. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 2005: 132: 2969-2980.
    • (2005) Development , vol.132 , pp. 2969-2980
    • Collombat, P.1    Hecksher-Sorensen, J.2    Broccoli, V.3
  • 69
    • 34047187934 scopus 로고    scopus 로고
    • Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas
    • Ait-Lounis A, Baas D, Barras E et al. Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas. Diabetes 2007: 56: 950-959.
    • (2007) Diabetes , vol.56 , pp. 950-959
    • Ait-Lounis, A.1    Baas, D.2    Barras, E.3
  • 70
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas
    • Wierup N, Svensson H, Mulder H et al. The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002: 107: 63-69.
    • (2002) Regul Pept , vol.107 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Mulder, H.3
  • 71
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    • Prado CL, Pugh-Bernard AE, Elghazi L et al. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A 2004: 101: 2924-2929.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2924-2929
    • Prado, C.L.1    Pugh-Bernard, A.E.2    Elghazi, L.3
  • 72
    • 38149057252 scopus 로고    scopus 로고
    • Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum
    • Wang Q, Elghazi L, Martin S et al. Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Dev Dyn 2008: 237: 51-61.
    • (2008) Dev Dyn , vol.237 , pp. 51-61
    • Wang, Q.1    Elghazi, L.2    Martin, S.3
  • 73
    • 25844456544 scopus 로고    scopus 로고
    • Genetic determinants of pancreatic epsilon-cell development
    • Heller RS, Jenny M, Collombat P et al. Genetic determinants of pancreatic epsilon-cell development. Dev Biol 2005: 286: 217-224.
    • (2005) Dev Biol , vol.286 , pp. 217-224
    • Heller, R.S.1    Jenny, M.2    Collombat, P.3
  • 75
    • 0037213587 scopus 로고    scopus 로고
    • Gene expression cascades in pancreatic development
    • Wilson ME, Scheel D, German MS. Gene expression cascades in pancreatic development. Mech Dev 2003: 120: 65-80.
    • (2003) Mech Dev , vol.120 , pp. 65-80
    • Wilson, M.E.1    Scheel, D.2    German, M.S.3
  • 76
    • 52049084555 scopus 로고    scopus 로고
    • Regeneration of pancreatic beta cells
    • Jun HS. Regeneration of pancreatic beta cells. Front Biosci 2008: 13: 6170-6182.
    • (2008) Front Biosci , vol.13 , pp. 6170-6182
    • Jun, H.S.1
  • 77
    • 34548507937 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage
    • Phillips BW, Hentze H, Rust WL et al. Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage. Stem Cells Dev 2007: 16: 561-578.
    • (2007) Stem Cells Dev , vol.16 , pp. 561-578
    • Phillips, B.W.1    Hentze, H.2    Rust, W.L.3
  • 78
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006: 24: 1392-1401.
    • (2006) Nat Biotechnol , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1    Bang, A.G.2    Eliazer, S.3
  • 79
    • 33645468639 scopus 로고    scopus 로고
    • Stem cells and diabetes treatment
    • Madsen OD. Stem cells and diabetes treatment. APMIS 2005: 113: 858-875.
    • (2005) APMIS , vol.113 , pp. 858-875
    • Madsen, O.D.1
  • 80
    • 33845696388 scopus 로고    scopus 로고
    • Towards cell therapy for diabetes
    • Madsen OD, Serup P. Towards cell therapy for diabetes. Nat Biotechnol 2006: 24: 1481-1483.
    • (2006) Nat Biotechnol , vol.24 , pp. 1481-1483
    • Madsen, O.D.1    Serup, P.2
  • 81
    • 34548321746 scopus 로고    scopus 로고
    • Stem cells therapy for type 1 diabetes
    • Lu P, Liu F, Yan L et al. Stem cells therapy for type 1 diabetes. Diabetes Res Clin Pract 2007: 78: 1-7.
    • (2007) Diabetes Res Clin Pract , vol.78 , pp. 1-7
    • Lu, P.1    Liu, F.2    Yan, L.3
  • 82
    • 36248934727 scopus 로고    scopus 로고
    • Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation
    • Karnieli O, Izhar-Prato Y, Bulvik S et al. Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 2007: 25: 2837-2844.
    • (2007) Stem Cells , vol.25 , pp. 2837-2844
    • Karnieli, O.1    Izhar-Prato, Y.2    Bulvik, S.3
  • 83
    • 0037820427 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells initiate pancreatic regeneration
    • Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003: 21: 763-770.
    • (2003) Nat Biotechnol , vol.21 , pp. 763-770
    • Hess, D.1    Li, L.2    Martin, M.3
  • 84
    • 43049173752 scopus 로고    scopus 로고
    • Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice
    • Gao X, Song L, Shen K et al. Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice. Biochem Biophys Res Commun 2008: 371: 132-137.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 132-137
    • Gao, X.1    Song, L.2    Shen, K.3
  • 85
    • 36248983813 scopus 로고    scopus 로고
    • Human marrow-derived mesodermal progenitor cells generate insulin-secreting islet-like clusters in vivo
    • Ai C, Todorov I, Slovak ML et al. Human marrow-derived mesodermal progenitor cells generate insulin-secreting islet-like clusters in vivo. Stem Cells Dev 2007: 16: 757-770.
    • (2007) Stem Cells Dev , vol.16 , pp. 757-770
    • Ai, C.1    Todorov, I.2    Slovak, M.L.3
  • 86
    • 33751232671 scopus 로고    scopus 로고
    • Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    • Lee RH, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A 2006: 103: 17438-17443.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17438-17443
    • Lee, R.H.1    Seo, M.J.2    Reger, R.L.3
  • 87
    • 40549142763 scopus 로고    scopus 로고
    • Cellular therapies for type 1 diabetes
    • Lee DD, Grossman E, Chong AS. Cellular therapies for type 1 diabetes. Horm Metab Res 2008: 40: 147-154.
    • (2008) Horm Metab Res , vol.40 , pp. 147-154
    • Lee, D.D.1    Grossman, E.2    Chong, A.S.3
  • 88
    • 50949121532 scopus 로고    scopus 로고
    • In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells
    • Gao F, Wu DQ, Hu YH et al. In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells. Transl Res 2008: 151: 293-302.
    • (2008) Transl Res , vol.151 , pp. 293-302
    • Gao, F.1    Wu, D.Q.2    Hu, Y.H.3
  • 89
    • 38949203785 scopus 로고    scopus 로고
    • The spleen -a potential source of new islets for transplantation?
    • Robertson SA, Rowan-Hull AM, Johnson PR. The spleen -a potential source of new islets for transplantation? J Pediatr Surg 2008: 43: 274-278.
    • (2008) J Pediatr Surg , vol.43 , pp. 274-278
    • Robertson, S.A.1    Rowan-Hull, A.M.2    Johnson, P.R.3
  • 90
    • 52449134233 scopus 로고    scopus 로고
    • Updates on stem cells and their applications in regenerative medicine
    • Bajada S, Mazakova I, Richardson JB et al. Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2008: 2: 169-183.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 169-183
    • Bajada, S.1    Mazakova, I.2    Richardson, J.B.3
  • 91
  • 92
    • 39549110217 scopus 로고    scopus 로고
    • Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus
    • Limbert C, Path G, Jakob F et al. Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus. Diabetes Res Clin Pract 2008: 79: 389-399.
    • (2008) Diabetes Res Clin Pract , vol.79 , pp. 389-399
    • Limbert, C.1    Path, G.2    Jakob, F.3
  • 93
    • 0035479834 scopus 로고    scopus 로고
    • Transdifferentiation and metaplasia -switching cell types
    • Slack JM, Tosh D. Transdifferentiation and metaplasia -switching cell types. Curr Opin Genet Dev 2001: 11: 581-586.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 581-586
    • Slack, J.M.1    Tosh, D.2
  • 94
    • 0036517883 scopus 로고    scopus 로고
    • How cells change their phenotype
    • Tosh D, Slack JM. How cells change their phenotype. Nat Rev Mol Cell Biol 2002: 3: 187-194.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 187-194
    • Tosh, D.1    Slack, J.M.2
  • 95
    • 33746218331 scopus 로고    scopus 로고
    • Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation
    • Tang DQ, Cao LZ, Chou W et al. Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation. Lab Invest 2006: 86: 829-841.
    • (2006) Lab Invest , vol.86 , pp. 829-841
    • Tang, D.Q.1    Cao, L.Z.2    Chou, W.3
  • 96
    • 32844462637 scopus 로고    scopus 로고
    • Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors
    • Tang DQ, Lu S, Sun YP et al. Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors. Lab Invest 2006: 86: 83-93.
    • (2006) Lab Invest , vol.86 , pp. 83-93
    • Tang, D.Q.1    Lu, S.2    Sun, Y.P.3
  • 97
    • 45249102494 scopus 로고    scopus 로고
    • Transdifferentiation of pancreatic ductal cells to endocrine beta-cells
    • Bonner-Weir S, Inada A, Yatoh S et al. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans 2008: 36: 353-356.
    • (2008) Biochem Soc Trans , vol.36 , pp. 353-356
    • Bonner-Weir, S.1    Inada, A.2    Yatoh, S.3
  • 98
    • 52049107060 scopus 로고    scopus 로고
    • Pancreatic acinar-to-beta cell transdifferentiation in vitro
    • Minami K, Seino S. Pancreatic acinar-to-beta cell transdifferentiation in vitro. Front Biosci 2008: 13: 5824-5837.
    • (2008) Front Biosci , vol.13 , pp. 5824-5837
    • Minami, K.1    Seino, S.2


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