Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell

Genesis (United States)

Volumn 30, Issue 3, 2001, Pages 137-140

  Yee, Nelson S ^a   Yusuff, Shamila ^a   Pack, Michael ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GENE PRODUCT; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DIGESTIVE SYSTEM; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; KNOCKOUT GENE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; STEM CELL; ZEBRA FISH;

ANIMALIA; DANIO RERIO;

EID: 0034903133     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.1049     Document Type: Article

References (19)

1. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
2. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
3. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
4. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes
5. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus
6. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum
7. A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene
8. Insulin-promoter-factor 1 is required for pancreas development in mice
9. Analysis of protein and gene expression
10. Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer
11. PDX-1 and Msx-2 expression in the regenerating and developing pancreas
12. Effective targeted gene 'knockdown' in zebrafish
13. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
14. The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells
15. PDX-1: An activator of genes involved in pancreatic development and islet gene expression
16. Regulation of left-right asymmetries in the zebrafish by Shh and bmp4
17. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
18. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
19. Zebrafish hhex regulates liver development and digestive organ chirality