Role of acetaldehyde in ethanol-induced elevation of the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in rats

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 10, 2008, Pages 1774-1781

  Boyd, Kevin N ^b   O'Buckley, Todd K ^b   Leslie Morrow, A ^a,b  

^a School of Medicine ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaldehyde; Ethanol; GABA A receptors; Neuroactive steroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ACETALDEHYDE; ALCOHOL; CYANAMIDE;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETALDEHYDE; ANIMALS; CEREBRAL CORTEX; CYANAMIDE; ETHANOL; MALE; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 52149110807     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00762.x     Document Type: Article

References (48)

1. Abe K, Yamaguchi S, Sugiura M, Saito H (1999) The ethanol metabolite acetaldehyde inhibits the induction of long-term potentiation in the rat dentate gyrus in vivo. Br J Pharmacol 127 : 1805 1810.
2. 2 system. Biochem Pharmacol 44 : 93 98.
3. Barbaccia ML, Affricano D, Trabucchi M, Purdy RH, Colombo G, Agabio R, Gessa GL (1999) Ethanol markedly increases "GABAergic'' neurosteroids in alcohol-preferring rats. Eur J Pharmacol 384 : R1 R2.
4. Beisswenger T, Holmquist B, Vallee B (1985) chi-ADH is the sole alcohol dehydrogenase isozyme in mammalian brains: implications and inferences. Proc Natl Acad Sci U S A 24 : 8369 8373.
5. Belelli D, Lambert JJ (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci 6 : 565 575.
6. Carmichael F, Israel Y, Crawford M, Minhas K, Saldivia V, Sandrin S, Campisi P, Orrgeo H (1991) Central nervous system effects of acetate: contribution to the central effects of ethanol. J Pharmacol Exp Ther 259 : 403 408.
7. A receptors, and ethanol dependence. Psychopharmacology 186 : 267 280.
8. Ford MM, Mark GP, Nickel JD, Phillips TJ, Finn DA (2007) Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res 179 : 265 272.
9. Fujimiya T, Yamaoka K, Ohbora Y, Aki T, Shinagawa H (2002) Michaelis-Menten elimination kinetics of acetaldehyde during ethanol oxidation. Alcohol Clin Exp Res 26 : 49S 54S.
10. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996) Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α- pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology 124 : 340 346.
11. Hirani K, Sharma AN, Jain NS, Ugale RR, Chopde CT (2005) Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 180 : 267 278.
12. Hodge CW, Nannini MA, Olive MF, Kelley SP, Mehmert KK (2001) Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. Alcohol Clin Exp Res 25 : 1441 1447.
13. Holdstock L, Penland SN, Morrow AL, De Wit H (2006) Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy- 5α-pregnan-20-one-like immunoreactivity in healthy men and women. Psychopharmacology 186 : 442 450.
14. Hu ZY, Bourreau E, Jung-Testas I, Robel P, Baulieu E-E (1987) Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc Natl Acad Sci U S A 84 : 8215 8219.
15. Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T (2005) Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin Exp Res 29 : 1959 1964.
16. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T (2002) Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12 : 621 626.
17. Jamal M, Ameno K, Wang W, Kumihashi M, Ameno S, Ikuo U, Shinji A, Ijiri I (2005) Inhibition of acetaldehyde metabolism decreases acetylcholine release in medial frontal cortex of freely moving rats. Brain Res 1039 : 90 96.
18. Janak PH, Redfern JEM, Samson HH (1998) The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol Clin Exp Res 22 : 1106 1112.
19. Janis GC, Devaud LL, Mitsuyama H, Morrow AL (1998) Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in male and female rats. Alcohol Clin Exp Res 22 : 2055 2061.
20. Khisti RT, VanDoren MJ, O'Buckley TK, Morrow AL (2003) Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats. Brain Res 980 : 255 265.
21. King SR, Manna PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K, Walsh LP, Parker KL, Stocco DM, Smith RG, Lamb DJ (2002) An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22 : 10613 10620.
22. Kinoshita H, Jessop DS, Finn DP, Coventry TL, Roberts DJ, Ameno K, Jiri I, Harbuz MS (2001) Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat. Alcohol Alcohol 36 : 59 64.
23. Lieber CS, DeCarli LM (1970) Hepatic microsomal ethanol-oxidizing system. J Biol Chem 245 : 2505 2512.
24. Manrique H, Miquel M, Aragon CM (2005) Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice. Drug Alcohol Depend 79 : 343 350.
25. Matthews DB, Morrow AL, Tokunaga S, McDaniel JR (2002) Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task. Alcohol Clin Exp Res 26 : 1747 1751.
26. Morrow AL, Janis GC, VanDoren MJ, Matthews DB, Samson HH, Janak PH, Grant KA (1999) Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? Alcohol Clin Exp Res 23 : 1933 1940.
27. Morrow AL, Porcu P, Boyd KN, Grant KA (2006) Hypothalamic-pituitary- adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior. Dialogues Clin Neurosci 8 : 463 477.
28. Morrow AL, Suzdak PD, Paul SM (1987) Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency. Eur J Pharmacol 142 : 483 485.
29. Morrow AL, VanDoren MJ, Penland SN, Matthews DB (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res Brain Res Rev 37 : 98 109.
30. Myers WD, Gibson S, Ng KT, Singer G (1987) Sex differences in acetaldehyde on body temperature and open-field performance in the rat. Drug Alcohol Depend 19 : 1 6.
31. Nyberg S, Andersson A, Zingmark E, Wahlstrom G, Backstrom T, Sundstrom-Poromaa I (2005) The effect of a low dose of alcohol on allopregnanolone serum concentrations across the menstrual cycle in women with severe premenstrual syndrome and controls. Psychoneuroendocrinology 30 : 892 901.
32. Ocaranza P, Quintanilla M, Tampier L, Karahanian E, Sapag A, Israel Y (2008) Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Alcohol Clin Exp Res 32 : 52 57.
33. Pierucci-Lagha A, Covault J, Feinn R, Khisti RT, Morrow AL, Marx CE, Shampine LJ, Kranzler HR (2006) Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol. Psychopharmacology 186 : 451 461.
34. Pierucci-Lagha A, Covault J, Feinn R, Nellissery M, Hernandez-Avila C, Oncken C, Morrow AL, Kranzler HR (2005) GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 30 : 1193 1203.
35. A receptors. Neuron 4 : 759 765.
36. Quertemont E (2004) Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol Psychiatry 9 : 570 581.
37. Quertemont E, Didone V (2006) Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol. Alcohol Res Health 29 : 258 265.
38. Quertemont E, Tambour S, Bernaerts P, Zimatkin SM, Tirelli E (2004) Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects. Psychopharmacology 177 : 84 92.
39. Quertemont E, Tambour S, Tirelli E (2005) The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies. Prog Neurobiol 75 : 247 274.
40. Quintanilla M, Tampier L, Sapag A, Israel Y (2005) Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet Genom 15 : 427 431.
41. Redila VA, Aliatas E, Smith BR, Amit Z (2002) Effects of ethanol on an acetaldehyde drug discrimination with a conditioned taste aversion procedure. Alcohol 28 : 103 109.
42. Shannon EE, Porcu P, Purdy RH, Grant KA (2005) Characterization of the discriminative stimulus effects of neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice. J Pharmacol Exp Ther 314 : 675 685.
43. Tambour S, Didone V, Tirelli E, Quertemont E (2006) Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice. Behav Brain Res 172 : 145 154.
44. Tokunaga S, McDaniel JR, Morrow AL, Matthews DB (2003) Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. Brain Res 967 : 273 280.
45. Torres JM, Ortega E (2003) Alcohol intoxication increases allopregnanolone levels in female adolescent humans. Neuropsychopharmacology 28 : 1207 1209.
46. Torres JM, Ortega E (2004) Alcohol intoxication increases allopregnanolone levels in male adolescent humans. Psychopharmacology 172 : 352 355.
47. VanDoren MJ, Matthews DB, Janis GC, Grobin AC, Devaud LL, Morrow AL (2000) Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 20 : 1982 1989.
48. Wall TL, Carr LG, Ehlers CL (2003) Protective associaton of genetic variation in alcohol dehydrogenase with alcohol dependence in native American Mission Indians. Am J Psychiatry 160 : 41 46.