메뉴 건너뛰기




Volumn 10, Issue 2, 2008, Pages 99-107

Growth factors as mediators of exercise actions on the brain

Author keywords

Adult hippocampal neurogenesis; Cognitive impairment; Hippocamus dependent learning; Insulin like growth factor 1; Physical exercise

Indexed keywords

GROWTH FACTOR; SOMATOMEDIN C; SIGNAL PEPTIDE;

EID: 52049094083     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12017-008-8026-1     Document Type: Review
Times cited : (62)

References (90)
  • 1
    • 0034656167 scopus 로고    scopus 로고
    • Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus
    • M. A. Aberg N. D. Aberg H. Hedbacker 2000 Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus Journal of Neuroscience 20 2896 2903
    • (2000) Journal of Neuroscience , vol.20 , pp. 2896-2903
    • Aberg, M.A.1    Aberg, N.D.2    Hedbacker, H.3
  • 2
    • 33645222277 scopus 로고    scopus 로고
    • Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain
    • N. D. Aberg K. G. Brywe J. Isgaard 2006 Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain Scientific World Journal 6 53 80
    • (2006) Scientific World Journal , vol.6 , pp. 53-80
    • Aberg, N.D.1    Brywe, K.G.2    Isgaard, J.3
  • 3
    • 33845379903 scopus 로고    scopus 로고
    • Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord
    • D. L. Adkins J. Boychuk M. S. Remple 2006 Motor training induces experience-specific patterns of plasticity across motor cortex and spinal cord Journal of Applied Physiology 101 1776 1782
    • (2006) Journal of Applied Physiology , vol.101 , pp. 1776-1782
    • Adkins, D.L.1    Boychuk, J.2    Remple, M.S.3
  • 5
    • 0347928852 scopus 로고    scopus 로고
    • Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors?
    • E. T. Ang P. T. Wong S. Moochhala 2003 Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors? Neuroscience 118 335 345
    • (2003) Neuroscience , vol.118 , pp. 335-345
    • Ang, E.T.1    Wong, P.T.2    Moochhala, S.3
  • 6
    • 28044440711 scopus 로고    scopus 로고
    • The relation between insulin-like growth factor I levels and cognition in healthy elderly: A meta-analysis
    • L. I. Arwert J. B. Deijen M. L. Drent 2005 The relation between insulin-like growth factor I levels and cognition in healthy elderly: A meta-analysis Growth Hormone & IGF Research 15 416 422
    • (2005) Growth Hormone & IGF Research , vol.15 , pp. 416-422
    • Arwert, L.I.1    Deijen, J.B.2    Drent, M.L.3
  • 7
    • 0028941681 scopus 로고
    • Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
    • K. D. Beck L. Powell-Braxton H. R. Widmer 1995 Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons Neuron 14 717 730
    • (1995) Neuron , vol.14 , pp. 717-730
    • Beck, K.D.1    Powell-Braxton, L.2    Widmer, H.R.3
  • 10
    • 0025933857 scopus 로고
    • Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins
    • C. R. Breese R. L. Ingram W. E. Sonntag 1991 Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins Journal of Gerontology 46 B180 B187
    • (1991) Journal of Gerontology , vol.46
    • Breese, C.R.1    Ingram, R.L.2    Sonntag, W.E.3
  • 11
    • 0036127172 scopus 로고    scopus 로고
    • High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease
    • B. Bulow L. Hagmar P. Orbaek 2002 High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease Clinical Endocrinology 56 183 193
    • (2002) Clinical Endocrinology , vol.56 , pp. 183-193
    • Bulow, B.1    Hagmar, L.2    Orbaek, P.3
  • 12
    • 0034520593 scopus 로고    scopus 로고
    • Neurodegeneration is associated to changes in serum insulin-like growth factors
    • S. Busiguina A. M. Fernandez V. Barrios 2000 Neurodegeneration is associated to changes in serum insulin-like growth factors Neurobiology of Disease 7 657 665
    • (2000) Neurobiology of Disease , vol.7 , pp. 657-665
    • Busiguina, S.1    Fernandez, A.M.2    Barrios, V.3
  • 13
    • 18144446836 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates effects of exercise on the brain
    • E. Carro A. Nunez S. Busiguina 2000 Circulating insulin-like growth factor I mediates effects of exercise on the brain Journal of Neuroscience 20 2926 2933
    • (2000) Journal of Neuroscience , vol.20 , pp. 2926-2933
    • Carro, E.1    Nunez, A.2    Busiguina, S.3
  • 14
    • 28044466172 scopus 로고    scopus 로고
    • Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I
    • E. Carro C. Spuch J. L. Trejo 2005 Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I Journal of Neuroscience 25 10884 10893
    • (2005) Journal of Neuroscience , vol.25 , pp. 10884-10893
    • Carro, E.1    Spuch, C.2    Trejo, J.L.3
  • 15
    • 0035426212 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy
    • E. Carro J. L. Trejo S. Busiguina 2001 Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy Journal of Neuroscience 21 5678 5684
    • (2001) Journal of Neuroscience , vol.21 , pp. 5678-5684
    • Carro, E.1    Trejo, J.L.2    Busiguina, S.3
  • 16
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I regulates brain amyloid-beta levels
    • E. Carro J. L. Trejo T. Gomez-Isla 2002 Serum insulin-like growth factor I regulates brain amyloid-beta levels Nature Medicine 8 1390 1397
    • (2002) Nature Medicine , vol.8 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3
  • 17
    • 0038348541 scopus 로고    scopus 로고
    • Brain repair and neuroprotection by serum insulin-like growth factor I
    • E. Carro J. L. Trejo A. Nunez 2003 Brain repair and neuroprotection by serum insulin-like growth factor I Molecular Neurobiology 27 153 162
    • (2003) Molecular Neurobiology , vol.27 , pp. 153-162
    • Carro, E.1    Trejo, J.L.2    Nunez, A.3
  • 18
    • 0027269766 scopus 로고
    • Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
    • M. J. Carson R. R. Behringer R. L. Brinster 1993 Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice Neuron 10 729 740
    • (1993) Neuron , vol.10 , pp. 729-740
    • Carson, M.J.1    Behringer, R.R.2    Brinster, R.L.3
  • 20
    • 34748869602 scopus 로고    scopus 로고
    • Running exercise- and antidepressant-induced increases in growth and survival-associated signaling molecules are IGF-dependent
    • 2
    • M. J. Chen A. A. Russo-Neustadt 2007 Running exercise- and antidepressant-induced increases in growth and survival-associated signaling molecules are IGF-dependent Growth Factors 25 2 118 131
    • (2007) Growth Factors , vol.25 , pp. 118-131
    • Chen, M.J.1    Russo-Neustadt, A.A.2
  • 21
    • 0032486473 scopus 로고    scopus 로고
    • Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I
    • H. L. Cheng E. L. Feldman 1998 Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I The Journal Biological Chemistry 273 14560 14565
    • (1998) The Journal Biological Chemistry , vol.273 , pp. 14560-14565
    • Cheng, H.L.1    Feldman, E.L.2
  • 22
    • 0035283404 scopus 로고    scopus 로고
    • Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner
    • D. Chrysis A. S. Calikoglu P. Ye 2001 Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner The Journal of Neuroscience 21 1481 1489
    • (2001) The Journal of Neuroscience , vol.21 , pp. 1481-1489
    • Chrysis, D.1    Calikoglu, A.S.2    Ye, P.3
  • 23
    • 0036602967 scopus 로고    scopus 로고
    • Exercise: A behavioral intervention to enhance brain health and plasticity
    • C. W. Cotman N. C. Berchtold 2002 Exercise: A behavioral intervention to enhance brain health and plasticity Trends in Neurosciences 25 295 301
    • (2002) Trends in Neurosciences , vol.25 , pp. 295-301
    • Cotman, C.W.1    Berchtold, N.C.2
  • 24
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: Key roles of growth factor cascades and inflammation
    • C. W. Cotman N. C. Berchtold L. A. Christie 2007 Exercise builds brain health: key roles of growth factor cascades and inflammation Trends in Neurosciences 30 464 472
    • (2007) Trends in Neurosciences , vol.30 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.A.3
  • 25
    • 34347252649 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor I signalling in neurons
    • D. Davila J. Piriz J. L. Trejo 2007 Insulin and insulin-like growth factor I signalling in neurons Frontiers in Bioscience 12 3194 3202
    • (2007) Frontiers in Bioscience , vol.12 , pp. 3194-3202
    • Davila, D.1    Piriz, J.2    Trejo, J.L.3
  • 26
    • 15444353137 scopus 로고    scopus 로고
    • Endurance training and its effect upon the activity of the GH-IGFs system in the elderly
    • M. Deuschle W. F. Blum J. Frystyk 1998 Endurance training and its effect upon the activity of the GH-IGFs system in the elderly International Journal of Sports Medicine 19 250 254
    • (1998) International Journal of Sports Medicine , vol.19 , pp. 250-254
    • Deuschle, M.1    Blum, W.F.2    Frystyk, J.3
  • 27
    • 0037411496 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) and cognitive decline in older persons
    • M. G. Dik S. M. Pluijm C. Jonker 2003 Insulin-like growth factor I (IGF-I) and cognitive decline in older persons Neurobiology of Aging 24 573 581
    • (2003) Neurobiology of Aging , vol.24 , pp. 573-581
    • Dik, M.G.1    Pluijm, S.M.2    Jonker, C.3
  • 28
    • 33646819345 scopus 로고    scopus 로고
    • Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    • Q. Ding S. Vaynman M. Akhavan 2006 Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function Neuroscience 140 823 833
    • (2006) Neuroscience , vol.140 , pp. 823-833
    • Ding, Q.1    Vaynman, S.2    Akhavan, M.3
  • 30
  • 31
    • 0032914119 scopus 로고    scopus 로고
    • GH response to exercise: Assessment of the pituitary refractory period, and relationship with circulating components of the GH-IGF-I axis in adolescent females
    • A. Eliakim J. A. Brasel D. M. Cooper 1999 GH response to exercise: assessment of the pituitary refractory period, and relationship with circulating components of the GH-IGF-I axis in adolescent females Journal of Pediatric Endocrinology & Metabolism 12 47 55
    • (1999) Journal of Pediatric Endocrinology & Metabolism , vol.12 , pp. 47-55
    • Eliakim, A.1    Brasel, J.A.2    Cooper, D.M.3
  • 32
    • 0031870556 scopus 로고    scopus 로고
    • Increased physical activity and the growth hormone-IGF-I axis in adolescent males
    • A. Eliakim J. A. Brasel S. Mohan 1998 Increased physical activity and the growth hormone-IGF-I axis in adolescent males The American Journal of Physiology 275 R308 R314
    • (1998) The American Journal of Physiology , vol.275
    • Eliakim, A.1    Brasel, J.A.2    Mohan, S.3
  • 33
    • 0346751060 scopus 로고    scopus 로고
    • VEGF is necessary for exercise-induced adult hippocampal neurogenesis
    • K. Fabel K. Fabel B. Tam 2003 VEGF is necessary for exercise-induced adult hippocampal neurogenesis The European Journal of Neuroscience 18 2803 2812
    • (2003) The European Journal of Neuroscience , vol.18 , pp. 2803-2812
    • Fabel, K.1    Fabel, K.2    Tam, B.3
  • 35
    • 0033046355 scopus 로고    scopus 로고
    • Neuroprotective actions of peripherally administered insulin-like growth factor I in the injured olivo-cerebellar pathway
    • A. M. Fernandez A. G. de Gonzalez la Vega B. Planas 1999 Neuroprotective actions of peripherally administered insulin-like growth factor I in the injured olivo-cerebellar pathway The European Journal of Neuroscience 11 2019 2030
    • (1999) The European Journal of Neuroscience , vol.11 , pp. 2019-2030
    • Fernandez, A.M.1    De Gonzalez La Vega, A.G.2    Planas, B.3
  • 36
    • 0029836793 scopus 로고    scopus 로고
    • Interaction of the signalling pathways of insulin-like growth factor-I and sex steroids in the neuroendocrine hypothalamus
    • L. M. Garcia-Segura M. Duenas M. C. Fernandez-Galaz 1996 Interaction of the signalling pathways of insulin-like growth factor-I and sex steroids in the neuroendocrine hypothalamus Hormone Research 46 160 164
    • (1996) Hormone Research , vol.46 , pp. 160-164
    • Garcia-Segura, L.M.1    Duenas, M.2    Fernandez-Galaz, M.C.3
  • 38
    • 0035025510 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep
    • J. Guan L. Bennet S. George 2001 Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep Journal of Cerebral Blood Flow and Metabolism 21 493 502
    • (2001) Journal of Cerebral Blood Flow and Metabolism , vol.21 , pp. 493-502
    • Guan, J.1    Bennet, L.2    George, S.3
  • 39
    • 0029005329 scopus 로고
    • Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease
    • Suppl
    • D. Hantai M. Akaaboune C. Lagord 1995 Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease Journal of the Neurological Science 129 Suppl 122 126
    • (1995) Journal of the Neurological Science , vol.129 , pp. 122-126
    • Hantai, D.1    Akaaboune, M.2    Lagord, C.3
  • 40
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • M. Holzenberger J. Dupont B. Ducos 2003 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 182 187
    • (2003) Nature , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3
  • 41
    • 14944358464 scopus 로고    scopus 로고
    • Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
    • B. A. Hoshaw J. E. Malberg I. Lucki 2005 Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects Brain Research 1037 204 208
    • (2005) Brain Research , vol.1037 , pp. 204-208
    • Hoshaw, B.A.1    Malberg, J.E.2    Lucki, I.3
  • 42
    • 0036083379 scopus 로고    scopus 로고
    • The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt
    • S. Humbert E. A. Bryson F. P. Cordelieres 2002 The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt Developmental Cell 2 831 837
    • (2002) Developmental Cell , vol.2 , pp. 831-837
    • Humbert, S.1    Bryson, E.A.2    Cordelieres, F.P.3
  • 43
    • 0033571908 scopus 로고    scopus 로고
    • Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
    • T. A. Jones C. J. Chu L. A. Grande 1999 Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats Journal of Neuroscience 19 10153 10163
    • (1999) Journal of Neuroscience , vol.19 , pp. 10153-10163
    • Jones, T.A.1    Chu, C.J.2    Grande, L.A.3
  • 44
    • 0034489209 scopus 로고    scopus 로고
    • A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly
    • S. Kalmijn J. A. Janssen H. A. Pols 2000 A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly Journal of Clinical Endocrinology and Metabolism 85 4551 4555
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , pp. 4551-4555
    • Kalmijn, S.1    Janssen, J.A.2    Pols, H.A.3
  • 45
    • 14844288911 scopus 로고    scopus 로고
    • Exercise your amyloid
    • S. L. Karsten D. H. Geschwind 2005 Exercise your amyloid Cell 120 572 574
    • (2005) Cell , vol.120 , pp. 572-574
    • Karsten, S.L.1    Geschwind, D.H.2
  • 46
    • 33750134859 scopus 로고    scopus 로고
    • My adventures with genes from the fountain of youth
    • C. Kenyon 2004 My adventures with genes from the fountain of youth Harvey Lectures 100 29 70
    • (2004) Harvey Lectures , vol.100 , pp. 29-70
    • Kenyon, C.1
  • 47
    • 33644759222 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions
    • G. C. Koopmans M. Brans F. Gomez-Pinilla 2006 Circulating insulin-like growth factor I and functional recovery from spinal cord injury under enriched housing conditions European Journal of Neurosciences 23 1035 1046
    • (2006) European Journal of Neurosciences , vol.23 , pp. 1035-1046
    • Koopmans, G.C.1    Brans, M.2    Gomez-Pinilla, F.3
  • 48
    • 31544454715 scopus 로고    scopus 로고
    • Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines
    • E. Koponen T. Rantamaki V. Voikar 2005 Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines Cellular and Molecular Neurobiology 25 973 980
    • (2005) Cellular and Molecular Neurobiology , vol.25 , pp. 973-980
    • Koponen, E.1    Rantamaki, T.2    Voikar, V.3
  • 49
    • 33847188027 scopus 로고    scopus 로고
    • Free insulin-like growth factor-I and cognitive function in older persons living in community
    • F. Landi E. Capoluongo A. Russo 2007 Free insulin-like growth factor-I and cognitive function in older persons living in community Growth Hormone & IGF Research 17 58 66
    • (2007) Growth Hormone & IGF Research , vol.17 , pp. 58-66
    • Landi, F.1    Capoluongo, E.2    Russo, A.3
  • 50
    • 0037076291 scopus 로고    scopus 로고
    • Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats
    • G. M. Le P. Steensland G. P. Le 2002 Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats Proceedings of the National Academy of Sciences of the United States of America 99 7119 7123
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , pp. 7119-7123
    • Le, G.M.1    Steensland, P.2    Le, G.P.3
  • 51
    • 0034495033 scopus 로고    scopus 로고
    • Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: Cross-sectional data from a healthy male cohort
    • E. Leifke V. Gorenoi C. Wichers 2000 Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort Clinical Endocrinology 53 689 695
    • (2000) Clinical Endocrinology , vol.53 , pp. 689-695
    • Leifke, E.1    Gorenoi, V.2    Wichers, C.3
  • 52
    • 0345528168 scopus 로고    scopus 로고
    • Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients
    • M. Lijffijt P. S. Van Dam J. L. Kenemans 2003 Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients Neuroscience Letters 353 123 126
    • (2003) Neuroscience Letters , vol.353 , pp. 123-126
    • Lijffijt, M.1    Van Dam, P.S.2    Kenemans, J.L.3
  • 53
    • 0032848721 scopus 로고    scopus 로고
    • Abundant production of brain-derived neurotrophic factor by adult visceral epithelia
    • M. Lommatzsch A. Braun A. Mannsfeldt 1999 Abundant production of brain-derived neurotrophic factor by adult visceral epithelia The American Journal of Pathology 155 1183 1193
    • (1999) The American Journal of Pathology , vol.155 , pp. 1183-1193
    • Lommatzsch, M.1    Braun, A.2    Mannsfeldt, A.3
  • 55
    • 0032483062 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 ameliorates age-related behavioral deficits
    • A. L. Markowska M. Mooney W. E. Sonntag 1998 Insulin-like growth factor-1 ameliorates age-related behavioral deficits Neuroscience 87 559 569
    • (1998) Neuroscience , vol.87 , pp. 559-569
    • Markowska, A.L.1    Mooney, M.2    Sonntag, W.E.3
  • 56
    • 0034976704 scopus 로고    scopus 로고
    • Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice
    • M. Miyata H. T. Kim K. Hashimoto 2001 Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice European Journal of Neurosciences 13 1945 1954
    • (2001) European Journal of Neurosciences , vol.13 , pp. 1945-1954
    • Miyata, M.1    Kim, H.T.2    Hashimoto, K.3
  • 58
    • 0036724341 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study
    • M. Neves-Pereira E. Mundo P. Muglia 2002 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study American Journal of Human Genetics 71 651 655
    • (2002) American Journal of Human Genetics , vol.71 , pp. 651-655
    • Neves-Pereira, M.1    Mundo, E.2    Muglia, P.3
  • 60
    • 18344401228 scopus 로고    scopus 로고
    • Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons
    • A. Nunez E. Carro I. Torres-Aleman 2003 Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons Journal of Neurophysiology 89 3008 3017
    • (2003) Journal of Neurophysiology , vol.89 , pp. 3008-3017
    • Nunez, A.1    Carro, E.2    Torres-Aleman, I.3
  • 61
    • 33751253741 scopus 로고    scopus 로고
    • Plasma IGF-I levels and cognitive performance in older women
    • O. Okereke J. H. Kang J. Ma 2007 Plasma IGF-I levels and cognitive performance in older women Neurobiology of Aging 28 135 142
    • (2007) Neurobiology of Aging , vol.28 , pp. 135-142
    • Okereke, O.1    Kang, J.H.2    Ma, J.3
  • 62
    • 0034668766 scopus 로고    scopus 로고
    • Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
    • J. R. O'Kusky P. Ye A. J. D'Ercole 2000 Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development Journal of Neuroscience 20 8435 8442
    • (2000) Journal of Neuroscience , vol.20 , pp. 8435-8442
    • O'Kusky, J.R.1    Ye, P.2    D'Ercole, A.J.3
  • 63
    • 0033963228 scopus 로고    scopus 로고
    • Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice
    • M. Ono Y. Itakura T. Nonomura 2000 Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice Metabolism 49 129 133
    • (2000) Metabolism , vol.49 , pp. 129-133
    • Ono, M.1    Itakura, Y.2    Nonomura, T.3
  • 64
    • 0032579839 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier to neurotrophins
    • W. Pan W. A. Banks A. J. Kastin 1998 Permeability of the blood-brain barrier to neurotrophins Brain Research 788 87 94
    • (1998) Brain Research , vol.788 , pp. 87-94
    • Pan, W.1    Banks, W.A.2    Kastin, A.J.3
  • 65
    • 34249910333 scopus 로고    scopus 로고
    • Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia
    • M. Ploughman Z. Attwood N. White 2007 Endurance exercise facilitates relearning of forelimb motor skill after focal ischemia European Journal of Neuroscience 25 3453 3460
    • (2007) European Journal of Neuroscience , vol.25 , pp. 3453-3460
    • Ploughman, M.1    Attwood, Z.2    White, N.3
  • 66
    • 29044439363 scopus 로고    scopus 로고
    • Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia
    • M. Ploughman S. Granter-Button G. Chernenko 2005 Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia Neuroscience 136 991 1001
    • (2005) Neuroscience , vol.136 , pp. 991-1001
    • Ploughman, M.1    Granter-Button, S.2    Chernenko, G.3
  • 67
    • 0032876475 scopus 로고    scopus 로고
    • Peripherally administered insulin-like growth factor-I preserves hindlimb reflex and spinal cord noradrenergic circuitry following a central nervous system lesion in rats
    • B. E. Pulford L.R. Whalen D. N. Ishii 1999 Peripherally administered insulin-like growth factor-I preserves hindlimb reflex and spinal cord noradrenergic circuitry following a central nervous system lesion in rats Experimental Neurology 159 114 123
    • (1999) Experimental Neurology , vol.159 , pp. 114-123
    • Pulford, B.E.1    Whalen, L.R.2    Ishii, D.N.3
  • 68
    • 0030792486 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training
    • C. A. Roelen W. R. de Vries H. P. Koppeschaar 1997 Plasma insulin-like growth factor-I and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training International Journal of Sports Medicine 18 238 241
    • (1997) International Journal of Sports Medicine , vol.18 , pp. 238-241
    • Roelen, C.A.1    De Vries, W.R.2    Koppeschaar, H.P.3
  • 69
    • 0031695214 scopus 로고    scopus 로고
    • Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects
    • A. Rollero G. Murialdo S. Fonzi 1998 Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects Neuropsychobiology 38 73 79
    • (1998) Neuropsychobiology , vol.38 , pp. 73-79
    • Rollero, A.1    Murialdo, G.2    Fonzi, S.3
  • 70
    • 0029347167 scopus 로고
    • Purification and identification of brain-derived neurotrophic factor from human serum
    • R. D. Rosenfeld L. Zeni M. Haniu 1995 Purification and identification of brain-derived neurotrophic factor from human serum Protein Expression and Purification 6 465 471
    • (1995) Protein Expression and Purification , vol.6 , pp. 465-471
    • Rosenfeld, R.D.1    Zeni, L.2    Haniu, M.3
  • 71
    • 28844432459 scopus 로고    scopus 로고
    • The insulin-like growth factor system and its pleiotropic functions in brain
    • V.C. Russo P. D. Gluckman E. L. Feldman 2005 The insulin-like growth factor system and its pleiotropic functions in brain Endocrine Reviews 26 916 943
    • (2005) Endocrine Reviews , vol.26 , pp. 916-943
    • Russo, V.C.1    Gluckman, P.D.2    Feldman, E.L.3
  • 72
    • 0030995896 scopus 로고    scopus 로고
    • Nerve growth factor levels in normal human sera
    • T. Serrano L. C. Lorigados 1996 Nerve growth factor levels in normal human sera Neuroreport 8 179 181
    • (1996) Neuroreport , vol.8 , pp. 179-181
    • Serrano, T.1    Lorigados, L.C.2
  • 73
    • 0037092425 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    • Y. Shirayama A. C. Chen S. Nakagawa 2002 Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression Journal of Neurosciences 22 3251 3261
    • (2002) Journal of Neurosciences , vol.22 , pp. 3251-3261
    • Shirayama, Y.1    Chen, A.C.2    Nakagawa, S.3
  • 74
    • 0344394948 scopus 로고    scopus 로고
    • Can the brain be protected through exercise? Lessons from an animal model of parkinsonism
    • A. D. Smith M. J. Zigmond 2003 Can the brain be protected through exercise? Lessons from an animal model of parkinsonism Experimental Neurology 184 31 39
    • (2003) Experimental Neurology , vol.184 , pp. 31-39
    • Smith, A.D.1    Zigmond, M.J.2
  • 75
    • 0030795556 scopus 로고    scopus 로고
    • Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1
    • W. E. Sonntag C. D. Lynch P. T. Cooney 1997 Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1 Endocrinology 138 3515 3520
    • (1997) Endocrinology , vol.138 , pp. 3515-3520
    • Sonntag, W.E.1    Lynch, C.D.2    Cooney, P.T.3
  • 76
    • 0028086162 scopus 로고
    • Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia
    • W. Stummer K. Weber B. Tranmer 1994 Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia Stroke 25 1862 1869
    • (1994) Stroke , vol.25 , pp. 1862-1869
    • Stummer, W.1    Weber, K.2    Tranmer, B.3
  • 77
    • 33745269576 scopus 로고    scopus 로고
    • Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice
    • J. Svensson M. Diez J. Engel 2006 Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice The Journal of Endocrinology 189 617 627
    • (2006) The Journal of Endocrinology , vol.189 , pp. 617-627
    • Svensson, J.1    Diez, M.2    Engel, J.3
  • 78
    • 0034925587 scopus 로고    scopus 로고
    • Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men
    • O. Tissandier G. Peres J. Fiet 2001 Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men European Journal of Applied Physiology 85 177 184
    • (2001) European Journal of Applied Physiology , vol.85 , pp. 177-184
    • Tissandier, O.1    Peres, G.2    Fiet, J.3
  • 79
    • 0034445988 scopus 로고    scopus 로고
    • Serum growth factors and neuroprotective surveillance: Focus on IGF-1
    • I. Torres-Aleman 2000 Serum growth factors and neuroprotective surveillance: Focus on IGF-1 Molecular Neurobiology 21 153 160
    • (2000) Molecular Neurobiology , vol.21 , pp. 153-160
    • Torres-Aleman, I.1
  • 80
    • 1642379156 scopus 로고    scopus 로고
    • Role of insulin-like growth factor I signaling in neurodegenerative diseases
    • J. L. Trejo E. Carro E. Garcia-Galloway 2004 Role of insulin-like growth factor I signaling in neurodegenerative diseases Journal of Molecular Medicine 82 156 162
    • (2004) Journal of Molecular Medicine , vol.82 , pp. 156-162
    • Trejo, J.L.1    Carro, E.2    Garcia-Galloway, E.3
  • 81
    • 2542549618 scopus 로고    scopus 로고
    • Role of serum insulin-like growth factor I in mammalian brain aging
    • Suppl A
    • J. L. Trejo E. Carro C. Lopez-Lopez 2004 Role of serum insulin-like growth factor I in mammalian brain aging Growth Hormone & IGF Research 14 Suppl A S39 S43
    • (2004) Growth Hormone & IGF Research , vol.14
    • Trejo, J.L.1    Carro, E.2    Lopez-Lopez, C.3
  • 82
    • 0036933516 scopus 로고    scopus 로고
    • Sedentary life impairs self-reparative processes in the brain: The role of serum insulin-like growth factor-I
    • J. L. Trejo E. Carro A. Nunez 2002 Sedentary life impairs self-reparative processes in the brain: the role of serum insulin-like growth factor-I Reviews in the Neurosciences 13 365 374
    • (2002) Reviews in the Neurosciences , vol.13 , pp. 365-374
    • Trejo, J.L.1    Carro, E.2    Nunez, A.3
  • 83
    • 0035283153 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus
    • J. L. Trejo E. Carro I. Torres-Aleman 2001 Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus The Journal of Neuroscience 21 1628 1634
    • (2001) The Journal of Neuroscience , vol.21 , pp. 1628-1634
    • Trejo, J.L.1    Carro, E.2    Torres-Aleman, I.3
  • 84
    • 38649115676 scopus 로고    scopus 로고
    • The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
    • J. L. Trejo M. Llorens-Martin I. Torres-Aleman 2008 The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis Molecular and Cellular Neurosciences 37 402 411
    • (2008) Molecular and Cellular Neurosciences , vol.37 , pp. 402-411
    • Trejo, J.L.1    Llorens-Martin, M.2    Torres-Aleman, I.3
  • 85
    • 36549062949 scopus 로고    scopus 로고
    • Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects
    • J. L. Trejo J. Piriz M. V. Llorens-Martin 2007 Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects Molecular Psychiatry 12 1118 1128
    • (2007) Molecular Psychiatry , vol.12 , pp. 1118-1128
    • Trejo, J.L.1    Piriz, J.2    Llorens-Martin, M.V.3
  • 87
    • 32644462785 scopus 로고    scopus 로고
    • Exercise differentially regulates synaptic proteins associated to the function of BDNF
    • S. S. Vaynman Z. Ying D. Yin 2006 Exercise differentially regulates synaptic proteins associated to the function of BDNF Brain Research 1070 124 130
    • (2006) Brain Research , vol.1070 , pp. 124-130
    • Vaynman, S.S.1    Ying, Z.2    Yin, D.3
  • 88
    • 0033305308 scopus 로고    scopus 로고
    • Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport
    • J. D. Wallace R. C. Cuneo R. Baxter 1999 Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: A potential test for GH abuse in sport The Journal of Clinical Endocrinology and Metabolism 84 3591 3601
    • (1999) The Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 3591-3601
    • Wallace, J.D.1    Cuneo, R.C.2    Baxter, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.