Exercise Induces BDNF and Synapsin I to Specific Hippocampal Subfields

Journal of Neuroscience Research

Volumn 76, Issue 3, 2004, Pages 356-362

  Vaynman, Shoshanna ^a   Ying, Zhe ^a   Gómez Pinilla, Fernando ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BDNF; Circuitry; Exercise; Hippocampus; Immunohistochemistry; Synapsin I

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; SYNAPSIN I;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; EXERCISE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; ENZYME INHIBITORS; HIPPOCAMPUS; MALE; MICROSPHERES; NEURONAL PLASTICITY; PHYSICAL CONDITIONING, ANIMAL; PROTEIN KINASE C; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; SYNAPSINS;

EID: 2342544136     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20077     Document Type: Article

References (51)

1. Adams B, Lee M, Fahnestock M, Racine RJ. 1997. Long-term potentiation trains induce mossy fiber sprouting. Brain Res 775:193-197.
2. Akagi S, Mizoguchi A, Sobue K, Nakamura H, Ide C. 1996. Localization of synapsin I in normal fibers and regenerating axonal sprouts of the rat sciatic nerve. Histochem Cell Biol 105:365-373.
3. Amaral DG, Witter MP. 1989. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31: 571-591.
4. Cavazos JE, Golarai G, Sutula TP. 1991. Mossy fiber synaptic reorganization induced in kindling: time course of development, progression, and permanence. J Neurosci 11:2795-2803.
5. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kutchel G, Miler FD. 1997. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18:257-267.
6. Connor B, Young D, Yan Q, Faull RL, Synek B, Dragunow M. 1997. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res 49:71-81.
7. Ferreira A. Chin LS, Li L, Lainer LM, Kosik KS, Greengard P. 1998. Distinct roles of synapsin I and synapsin II during neuronal development. Mol Med 4:22-28.
8. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B. 1996. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotropins in the hippocampus. Nature 381:706-709.
9. Fordyce DE, Farrar RP. 1991. Enhancement of spatial learning in F344 rats by physical activity and related learning-associated alterations in hippocampal and cortical cholinergic functioning. Behav Brain Res 46:123-133.
10. Fordyce DE, Wehner JM. 1993. Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Res 619:111-119.
11. Geddes JW, Chang-Chui H, Cooper SM, Lott IT, Cotman CW. 1986. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease. Brain Res 399:156-161.
12. Gómez-Pinilla F, So V, Kesslak JP. 2001a. Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus. Brain Res 904:13-19.
13. Gómez-Pinilla F, Ying Z, Opazo P, Roy RR, Edgerton VR. 2001b. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur J Neurosci 13:1078-1084.
14. Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. 1996. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci 7:222-228.
15. Greengard P, Valtorta F, Czernik AJ, Benfenati F. 1993. Synaptic vesicle phosphorylation and regulation of synaptic function. Science 259:780-785.
16. Grealy MA, Johnson DA, Rushton SK. 1999. Improving cognitive function after brain injury: the use of exercise and virtual reality. Arch Phys Med Rehabil 80:661-667.
17. Griesbach GS, Hovda DA, Molteni R, Gómez-Pinilla F. 2002. Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity. J Neurotrauma 19:803-814.
18. Haubensak W, Narz F, Heumann R, Lessmann V. 1998. BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons. J Cell Sci 111:1483-1493.
19. Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, Sihra TS. 2000. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci 3:323-329.
20. Kafitz KW, Rose CR, Thoenen H, Konnerth A. 1999. Neurotrophinevoked rapid excitation through TrkB receptors. Nature 401:918-921.
21. Kang H, Welcher AA, Shelton D, Schuman EM. 1997. Neurotropins and time: different roles for TrkB signaling in hippocampal long-term potentiation. Neuron 19:653-664.
22. Kim YH, Rhyu IJ, Park KW, Eun BL, Kim YI, Rha HK, Kim DS, Jo YH, Whang KT, Kim MS. 2001. The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures. Neuroreport 12:3243-3246.
23. Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T. 1995. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotropic factor. Proc Natl Acad Sci USA 92:8856-8860.
24. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA, Colombe A. 1999. Aging, fitness, and neurocognitive function. Nature 400:418-419.
25. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. 2001. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58:498-504.
26. Lom B, Cohen-Cory S. 1999. Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo. J Neurosci 19:9928-9938.
27. Lu B, Figurov A. 1997. Role of neurotrophins in synapse development and plasticity. Rev Neurosci 8:1-12.
28. Mattson MP. 2000. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res 886:47-53.
29. Melloni Jr RH, Apostolides PJ, Hamos JE, DeGennaro LJ. 1994. Dynamics of synapsin I gene expression during the establishment and restoration of functional synapses in the rat hippocampus. Neuroscience 58:683-703.
30. Messaoudi E, Bardsen K, Srebro B, Bramham CR. 1998. Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. J Neurophysiol 79:496-499.
31. Molteni R, Ying Z, Gómez-Pinilla F. 2002. Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur J Neurosci 16:1107-1116.
32. Morimoto K, Sato K, Sato S, Yamada N, Hayabara T. 1998. Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation. Brain Res 783:57-62.
33. Neeper SA, Gómez-Pinilla F, Choi J, Cotman C. 1995. Exercise and brain neurotrophins. Nature 373:109.
34. Neeper SA, Gómez-Pinilla F, Choi J, Cotman C. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 726:49-56.
35. Nguyen P, Kandel ER. 1996. A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. J Neurosci 16:3189-3198.
36. Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M. 1992. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088.
37. Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hobson JA. 1989. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Science 245:984-986.
38. Riddle DR, Lo DC, Katz LC. 1995. NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation. Nature 378: 189-191.
39. Riddle DR, Katz LC, Lo DC. 1997. Focal delivery of neurotrophins into the central nervous system using fluorescent latex microspheres. Biotechniques 23:928-937.
40. Rocamora N, Welker E, Pascual M, Soriano E. 1996. Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation. J Neurosci 16:4411-4419.
41. Samorajski T, Delaney C, Durham L, Ordy JM, Johnson JA, Dunlap WP. 1985. Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice. Neurobiol Aging 6:17-24.
42. Sato K, Morimoto K, Suemaru S, Sato T, Yamada N. 2002. Increased synapsin I immunoreactivity during long-term potentiation in rat hippocampus. Brain Res 872:219-222.
43. Scharfman HE. 1997. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J Neurophysiol 78:1082-1095.
44. Scharfman HE, Goodman JH, Sollas AL. 1999. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. J Neurosci 19:5619-5631.
45. Suemaru S, Sato K, Morimoto K, Yamada N, Sato T, Kuroda S. 2000. Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy. Neuroreport 11:1319-1322.
46. Suominen-Troyer S, Davis KJ, Ismail AH, Salvendy G. 1986. Impact of physical fitness on strategy development in decision-making tasks. Percept Mot Skills 62:71-77.
47. Takei Y, Harada A, Takeda S, Kobayashi K, Terada S, Noda T, Taka Hirokawa N. 1995. Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system. J Cell Biol 131:1789-1800.
48. van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427-13434.
49. Watanabe Y, Bakheit AM, McLellan DL. 1998. A study of the effectiveness of botulinum toxin type A (Dysport) in the management of muscle spasticity. Disabil Rehabil 20:62-65.
50. Wu A, Molteni R, Ying Z, Gómez-Pinilla F. 2003. A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor. Neuroscience 119:365-375.
51. Zurmohle U, Herms J, Schlingensiepen R, Brysch W, Schlingensiepen KH. 1996. Changes in the expression of synapsin I and II messenger RNA during postnatal rat brain development. Exp Brain Res 108:441-449.