The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats

Toxicology and Applied Pharmacology

Volumn 232, Issue 2, 2008, Pages 280-291

  Nishiya, Takayoshi ^a   Mori, Kazuhiko ^a   Hattori, Chiharu ^a   Kai, Kiyonori ^a   Kataoka, Hiroko ^a   Masubuchi, Noriko ^a   Jindo, Toshimasa ^a   Manabe, Sunao ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Glutathione; Hepatotoxicity; Microarray; Oxidative stress; Tienilic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; BILE ACID; BILIRUBIN; BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; TIENILIC ACID; TRANSCRIPTION FACTOR NRF2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE ACID BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; GENE CONTROL; GENE EXPRESSION; GLUTATHIONE METABOLISM; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; UNINDEXED SEQUENCE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; LIVER DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TICRYNAFEN;

RATTUS;

EID: 52049083469     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.06.024     Document Type: Article

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