Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction

Toxicological Sciences

Volumn 91, Issue 2, 2006, Pages 651-659

  Nishiya, Takayoshi ^a   Kataoka, Hiroko ^a   Mori, Kazuhiko ^a   Goto, Mayumi ^a   Sugawara, Tadaki ^a   Furuhama, Kazuhisa ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Eisai hyperbilirubinuria rat; Heme oxygenase 1; Hyperbilirubinemia; Tienilic acid; Transporters

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; HEME OXYGENASE 1; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3; TIENILIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID SYNTHESIS; BILE FLOW; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME DEGRADATION; FLOW RATE; HYPERBILIRUBINEMIA; LIVER STRUCTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN EXPRESSION; RAT; RAT STRAIN; RNA ANALYSIS; TOXICITY TESTING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BILIRUBIN; DISEASE MODELS, ANIMAL; DIURETICS; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HYPERBILIRUBINEMIA; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RNA, MESSENGER; SYMPORTERS; TICRYNAFEN;

EID: 33744796557     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj162     Document Type: Article

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