Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines

British Journal of Cancer

Volumn 88, Issue 6, 2003, Pages 951-956

  Okuno, S ^a   Sato, H ^a   Kuriyama Matsumura, K ^a   Tamba, M ^a   Wang, H ^a   Sohda, S ^a   Hamada, H ^a   Yoshikawa, H ^a   Kondo, T ^b   Bannai, S ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cisplatin; Cystine; Drug resistance; Glutathione; Transporter

Indexed keywords

CISPLATIN; CYSTINE; GLUTATHIONE;

AMINO ACID TRANSPORT; ARTICLE; CANCER RESISTANCE; CELL CULTURE; CELL MEMBRANE; COLON CANCER; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL;

AMINO ACID TRANSPORT SYSTEMS; ANTINEOPLASTIC AGENTS; CISPLATIN; COLONIC NEOPLASMS; CYSTINE; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; FEMALE; GLUTATHIONE; HUMANS; OVARIAN NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0242499988     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600786     Document Type: Article

References (31)

1. Andrews PA, Howell SB (1990) Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance. Cancer Cells 2: 35-43
2. Bannai S (1984) Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents. J Biol Chem 259: 2435-2440
3. Bannai S (1986) Exchange of cystine and glutamate across plasma membrane of human fibroblasts. J Biol Chem 261: 2256-2263
4. Bannai S, Ishii T (1982) Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effect of glutamate and homocysteate. J Cell Physiol 112: 265-272
5. Bannai S, Kitamura E (1980) Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture. J Biol Chem 255: 2372-2376
6. Bannai S, Kitamura E (1981) Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture. J Biol Chem 256: 5770-5772
7. Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J, Louie KG, Knutsen T, McKoy WM, Young RC, Ozols RF (1987) Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 47: 414-418
8. Christensen HN (1990) Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 70: 43-77
9. Cotgreave IA, Moldeus P (1986) Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems. J Biochem Biophys Methods 13: 231-249
10. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME (1992) High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 89: 3070-3074
11. Goto S, Yoshida K, Morikawa T, Urata Y, Suzuki K, Kondo T (1995) Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells. Cancer Res 55: 4297-4301
12. Iida T, Mori E, Mori K, Goto S, Urata Y, Oka M, Kohno S, Kondo T (1999) Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells. Int J Cancer 82: 405-411
13. Johnson SW, Laub PB, Beesley JS, Ozols RF, Hamilton TC (1997) Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines. Cancer Res 57: 850-856
14. Johnsson A, Zeelenberg I, Min Y, Hilinsky J, Berry C, Howell SB, Los G (2000) Identification of genes differentially expressed in association with acqired cisplatin resistance. Br J Cancer 83: 1047-1054
15. Li J, Feng Q, Kim JM, Schneiderman D, Liston P, Li M, Vanderhyden B, Faught W, Fung MF, Senterman M, Korneluk RG, Tsang BK (2001) Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins. Endocrinology 142: 370-380
16. Li Q, Tsang B, Bostick-Bruton F, Reed E (1999) Modulation of excision repair cross complementation group 1 (ERCC-1) mRNA expression by pharmacological agents in human ovarian carcinoma cells. Biochem Pharmacol 57: 347-353
17. Meister A (1988) Glutathione metabolism and its selective modification. J Biol Chem 263: 17205-17208
18. Mistry P, Kelland LR, Abel G, Sidhar S, Harrap KR (1991) The relationships between glutathione, glutathlone-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer 64: 215-220
19. Palacin M, Estevez R, Bertran J, Zorzano A (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78: 969-1054
20. Patterson Jr MK (1979) Measurement of growth and viability of cells in culture. Method Enzymol 58: 141-152
21. Perez RP, Hamilton TC, Ozols RF, Young RC (1993) Mechanisms and modulation of resistance to chemotherapy in ovarian cancer. Cancer 71: 1571-1580
22. Reed E (1998) Platinum-DNA adduct, nucleotide excision repair and platinum based anti- cancer chemotherapy. Cancer Treat Rev 24: 331-344
23. Richman PG, Meister A (1975) Regulation of γ-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem 250: 1422-1426
24. Rosenberg B (1985) Fundamental studies with cisplatin. Cancer 55: 2303-2316
25. Sato H, Tamba M, Ishii T, Bannai S (1999) Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 274: 11455-11458
26. Sato H, Tamba M, Kuriyama-Matsumura K, Okuno S, Bannai S (2000) Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc. Antioxid Redox Signal 2: 665-671
27. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522
28. Timmer-Bosscha H, Timmer A, Meijer C, de Vries EG, de Jong B, Oosterhuis JW, Mulder NH (1993) cis-Diamminedichloroplatinum(ii) resistance in vitro and in vivo in human embryonal carcinoma cells. Cancer Res 53: 5707-5713
29. 12 compounds. Proc Natl Acad Sci USA 72: 73-77
30. Wasenius VM, Jekunen A, Monni O, Joensuu H, Aebi S, Howell SB, Knuutila S (1997) Comparative genomic hybridization analysis of chromosomal changes occurring during development of acquired resistance to cisplatin in human ovarian carcinoma cells. Genes Chromosomes Cancer 18: 286-291
31. Yao KS, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC (1995) Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res 55: 4367-4374