Developmental biology: LIN-12/notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans

Science

Volumn 310, Issue 5752, 2005, Pages 1330-1333

  Yoo, Andrew S ^a   Greenwald, Iva ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSTALK; ENZYMES; FEEDBACK; PROTEINS; SIGNALING;

CELL-CELL INTERACTION; EPIDERMAL GROWTH FACTOR RECEPTOR (EFGR); MITOGEN-ACTIVATED PROTEIN KINASE (MAPK); VULVUL PRECURSOR CELLS;

CELL CULTURE;

EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LIN 12 PROTEIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; UNCLASSIFIED DRUG; VAV 1 PROTEIN; VAV PROTEIN; YELLOW FLUORESCENT PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; LIN 12 PROTEIN, C ELEGANS; LIN-12 PROTEIN, C ELEGANS; MEMBRANE PROTEIN; VAV 1 PROTEIN, C ELEGANS; VAV-1 PROTEIN, C ELEGANS;

BIOLOGY;

3' UNTRANSLATED REGION; ARTICLE; CAENORHABDITIS ELEGANS; CELL FATE; CELL INTERACTION; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; MIR 61 GENE; NONHUMAN; ONCOGENE; ORTHOLOGY; PRIORITY JOURNAL; RNA GENE; SIGNAL TRANSDUCTION; STEM CELL; ANIMAL; BIOLOGY; CYTOLOGY; FEEDBACK SYSTEM; FEMALE; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; REGULATORY SEQUENCE; TRANSGENIC ANIMAL; VULVA;

CAENORHABDITIS ELEGANS;

3' UNTRANSLATED REGIONS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; FEEDBACK, BIOCHEMICAL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HELMINTH; MEMBRANE PROTEINS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-VAV; REGULATORY SEQUENCES, NUCLEIC ACID; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC; VULVA;

EID: 28144458897     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1119481     Document Type: Article

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29. We are grateful to X. Zhou for performing microinjections; and to O. Hobert, R. Mann, and D. Shaye for discussion and insightful comments on the manuscript This work was supported by NIH grant CA095389 (to I.G.). I.G. is an investigator with the Howard Hughes Medical Institute.