Activity based chemical proteomics: Profiling proteases as drug targets

Current Drug Discovery Technologies

Volumn 5, Issue 3, 2008, Pages 200-212

  Heal, William Percy ^a   Wickramasinghe, Sasala Roshinie ^a   Tate, Edward William ^a,b  

^a South Kensington Campus ^*  (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Activity based probes; Cleavable linker; Click chemistry; Drug targets; Protease; Proteomics; Solid phase synthesis; Target validation

Indexed keywords

CYSTEINE PROTEINASE; METALLOPROTEINASE; PROTEINASE; SERINE PROTEINASE; THREONINE PROTEINASE;

ACTIVITY BASED CHEMICAL PROTEOMICS; ACTIVITY BASED PROBE; ACTIVITY BASED PROTEIN PROFILING; ARTHRITIS; BINDING AFFINITY; BIOTECHNOLOGY; DIABETES MELLITUS; DISEASE COURSE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME REGULATION; ENZYME SPECIFICITY; FLUORESCENCE; HUMAN; ISOTOPE LABELING; MALARIA; MOLECULAR PROBE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SOLID PHASE SYNTHESIS; SOLUBILITY; TECHNIQUE;

AFFINITY LABELS; ANIMALS; CATALYTIC DOMAIN; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; FLUORESCENT DYES; HUMANS; ISOTOPES; MOLECULAR PROBES; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEOMICS;

EID: 51349154761     PISSN: 15701638     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016308785739866     Document Type: Review

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