Quantitative proteome analysis by solid-phase isotope tagging and mass spectrometry

Nature Biotechnology

Volumn 20, Issue 5, 2002, Pages 512-515

  Zhou, Huilin ^a   Ranish, Jeffrey A ^a   Watts, Julian D ^a   Aebersold, Ruedi ^a  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ANALYSIS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS; YEAST;

ISOTOPIC LABELING;

BIOTECHNOLOGY;

CYSTEINE; GALACTOSE; PEPTIDE; PROTEOME;

ACCURACY; AMINO ACID SEQUENCE; ARTICLE; INTERMETHOD COMPARISON; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEOMICS; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; TECHNIQUE;

CHROMATOGRAPHY, LIQUID; CYSTEINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPES; MASS SPECTROMETRY; MODELS, CHEMICAL; PEPTIDES; PROTEINS; SACCHAROMYCES CEREVISIAE; TIME FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036246088     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0502-512     Document Type: Article

References (15)

1. Solid phase synthesis
2. Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method
3. Microchemical facility for the analysis and synthesis of genes and proteins
4. A protein sequenator
5. Quantitative analysis of complex protein mixtures using isotopecoded affinity tags
6. Reagents for combinatorial organic synthesis: Development of a new o-nitrobenzyl photolabile linker for solid phase synthesis
7. Accurate quantitation of protein expression and site-specific phosphorylation
8. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
9. Quantitative profiling of differentiation-induced membrane associated proteins using isotope-coded affinity tags and mass spectrometry
10. Large-scale analysis of the yeast proteome by multidimensional protein identification technology
11. The molecular and cellular biology of the yeast Saccharomyces
12. A systematic approach to the analysis of protein phosphorylation
13. Synthesis of N-2,2,2(trichloroethoxycarbonyl)-L-amino acids and N-(9-fiuorenylmethoxycarbonyl)-Lamino acids involving succinimidoxy anion as a leaving group in amino acid protection
14. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database