Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe

Biological Chemistry

Volumn 386, Issue 4, 2005, Pages 401-406

  Florent, Isabelle ^a   Lecaille, Fabien ^b   Montagne, Jean Jacques ^c   Gauthier, Francis ^b   Schrével, Joseph ^a   Lalmanach, Gilles ^b  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b INSERM   (France)

^c INSTITUT JACQUES MONOD   (France)

Author keywords

2 D electrophoresis; Activity based probe; Affinity labelling; Cathepsin; Cystatin; Malaria

Indexed keywords

CYSTATIN; CYSTEINE PROTEINASE; FALCIPAIN DERIVATIVE; UNCLASSIFIED DRUG; FALCIPAIN 2; FALCIPAIN 3; PEPTIDE FRAGMENT;

AFFINITY LABELING; ARTICLE; DNA FINGERPRINTING; ENZYME ACTIVITY; ENZYME ANALYSIS; ISOELECTRIC POINT; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN TARGETING; TWO DIMENSIONAL ELECTROPHORESIS; ANIMAL; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR PROBE;

PLASMODIUM FALCIPARUM;

ANIMALS; CYSTATINS; CYSTEINE ENDOPEPTIDASES; MOLECULAR PROBES; PEPTIDE FRAGMENTS; PLASMODIUM FALCIPARUM;

EID: 25144497589     PISSN: 14316730     EISSN: 14316730     Source Type: Journal    
DOI: 10.1515/BC.2005.048     Document Type: Article

References (33)

1. Anastasi, A., Brown, M.A., Kembhavi, A.A., Nicklin, M.J., Sayers, C.A., Sunter, D.C., and Barrett, A.J. (1983). Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. Biochem. J. 211, 129-138.
2. Aoki, S., Li, J., Itagaki, S., Okech, B.A., Egwang, T.G., Matsuoka, H., Palacpac, N.M., Mitamura, T., and Horii, T. (2002). Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth. J. Biol. Chem. 277, 47533-47540.
3. Barrett, A.J. and Rawlings, N.D. (2001). Evolutionary lines of cysteine peptidases. Biol. Chem. 382, 727-733.
4. Barrett, A.J., Kembhavi, A.A., Brown, M.A., Kirschke, H., Knight, C.G. Tamai, M., and Hanada, K. (1982). L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189-198.
5. Blackman, M.J. (2000). Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets. Curr. Drug Targets 1, 59-83.
6. Chagas, J.R., Authie, E., Serveau, C., Lalmanach, G., Juliano, L., and Gauthier, F. (1997). A comparison of the enzymatic properties of the major cysteine proteinases from Trypanosoma congolense and Trypanosoma cruzi. Mol. Biochem. Parasitol. 88, 85-94.
7. Eksi, S., Czesny, B., Greenbaum, D.C., Bogyo, M. and Williamson, K.C. (2004). Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth. Mol. Microbiol. 53, 243-250.
8. Francis, S.E., Gluzman, I.Y., Oksman, A., Banerjee, D., and Goldberg, D.E. (1996). Characterization of native falcipain, an enzyme involved in Plasmodium falciparum hemoglobin degradation. Mol. Biochem. Parasitol. 83, 189-200.
9. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S., et al. (2002). Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511.
10. Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L., and Goldberg, D.E. (1994). Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway. J. Clin. Invest. 93, 1602-1608.
11. Greenbaum, D., Medzihradszky, K.F., Burlingame, A., and Bogyo, M. (2000) Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem. Biol. 7, 569-581.
12. Greenbaum, D.C., Baruch, A., Grainger, M., Bozdech, Z., Medzihradszky, K.F., Engel, J., DeRisi, J., Holder, A.A., and Bogyo, M. (2002). A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science 298, 2002-2006.
13. Grellier, P., Picard, I., Bernard, F., Mayer, R., Heidrich, H.G., Monsigny, M., and Schrevel, J. (1989). Purification and identification of a neutral endopeptidase in Plasmodium falciparum schizonts and merozoites. Parasitol. Res. 75, 455-460.
14. Hodder, A.N., Drew, D.R., Epa, V.C., Delorenzi, M., Bourgon, R., Miller, S.K., Moritz, R.L., Frecklington, D.F., Simpson, R.J., Speed, T.P., Pike, R.N., and Crabb, B.S. (2003). Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5. J. Biol. Chem. 278, 48169-48177.
15. Klemba, M., Gluzman, I. and Goldberg, D.E. (2004). A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation. J. Biol. Chem. 279, 43000-43007.
16. Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
17. Lalmanach, G., Mayer, R., Serveau, C., Scharfstein, J. and Gauthier, F. (1996). Biotin-labelled peptidyl diazomethane inhibitors derived from the substrate-like sequence of cystatin: targeting of the active site of cruzipain, the major cysteine proteinase of Trypanosoma cruzi. Biochem. J. 318, 395-399.
18. Lalmanach, G., Boulange, A., Serveau, C., Lecaille, F., Scharfstein, J., Gauthier, F., and Authie, E. (2002). Congopain from Trypanosoma congolense: drug target and vaccine candidate. Biol. Chem. 383, 739-749.
19. Merril, C.R., Goldman, D., and Van Keuren, M.L. (1984). Gel protein stains: silver stain. Methods Enzymol. 104, 441-447.
20. Miller, S.K., Good, R.T., Drew, D.R., Delorenzi, M., Sanders, P.R., Hodder, A.N., Speed, T.P., Cowman, A.F., de Koning-Ward, T.F., and Crabb, B.S. (2002). A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J. Biol. Chem. 277, 47524-47532.
21. Ridley, R.G. (1997). Plasmodium: drug discovery and development - an industrial perspective. Exp. Parasitol. 87, 293-304.
22. Rosenthal, P.J. (1998). Proteases of malaria parasites: new targets for chemotherapy. Emerg. Infect. Dis. 4, 49-57.
23. Rosenthal, P.J. (2004). Cysteine proteases of malaria parasites. Int. J. Parasitol. 34, 1489-1499.
24. Rosenthal, P.J. and Nelson, R.G. (1992). Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. Mol. Biochem. Parasitol. 51, 143-152.
25. Salas, F., Fichmann, J., Lee, G.K., Scott, M.D., and Rosenthal, P.J. (1995). Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. Infect. Immun. 63, 2120-2125.
26. Segel, I.H. (1975). Enzyme Kinetics (New York, USA: John Wiley and Sons).
27. Shenai, B.R., Sijwali, P.S., Singh, A., and Rosenthal, P.J. (2000). Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J. Biol. Chem. 275, 29000-29010.
28. Sijwali, P.S. and Rosenthal, P.J. (2004). Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 101, 4384-4389.
29. Sijwali, P., B, R.S., Gut, J., Singh, A., and Rosenthal, P.J. (2001). Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem. J. 360, 481-489.
30. Sijwali, P.S., Kato, K., Seydel, K.B., Gut,J., Lehman, J., Klemba, M., Goldberg, D.E., Miller, L.H., and Rosenthal, P.J. (2004). Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc. Natl. Acad. Sci. USA 101, 8721-8726.
31. Trager, W. and Jensen, J.B. (1976). Human malaria parasites in continuous culture. Science 193, 673-675.
32. Wu, Y., Wang, X., Liu, X., and Wang, Y. (2003). Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite. Genome Res. 13, 601-616.
33. World Health Organisation (1999). Report on Infectious Diseases (Geneva, Switzerland: World Health Organisation).