Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents

Experimental and Toxicologic Pathology

Volumn 48, Issue 2-3, 1996, Pages 113-119

  Ito, Nobuyuki ^a,b   Hasegawa, Ryohei ^a   Imaida, Katsumi ^a   Hirose, Masao ^a   Shirai, Tomoyuki ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Bioassays carcinogenesis; Carcinogenesis, bioassays; Chemoprevention, carcinogenesis; Chemopreventive agents

Indexed keywords

ALCOHOL; ANTIOXIDANT; BENZOIN; BUTYLATED HYDROXYANISOLE; CAFFEIC ACID; CAPTAN; CARCINOGEN; CATECHIN; CATECHOL; CLOFIBRATE; DIARYL SULFIDE; DIETHYLNITROSAMINE; ESCULIN; ETHIONINE; EUGENOL; FERULIC ACID; GALLIC ACID; HYDROQUINONE; INDOMETACIN; LIMONENE; METHYLTESTOSTERONE; N (2 FLUORENYL)ACETAMIDE; NITROSOMORPHOLINE; PARACETAMOL; PROTECTIVE AGENT; SESAMOL; TAMOXIFEN; THEOBROMINE; TOCOPHEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL MODEL; BIOASSAY; CANCER; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; RAT;

EID: 0029873749     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(96)80031-5     Document Type: Conference Paper

References (40)

1. ASHBY J, TENNANT RW: Definitive relationship among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat Res 1991; 257: 229-306.
2. DOLL R: Epidemiology and the prevention of cancer: some recent developments. J Cancer Res Clin Oncol 1988; 114: 447-458.
3. FUKUSHIMA S, HAGIWARA A, HIROSE M, et al.: Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats. Jpn J Cancer Res 1991; 82: 642-649.
4. FUKUSHIMA S, SAKATA T, TAGAWA Y, et al.: Different modifying response of butylated hydroxyanisole, butylated hydroxytoluene, and other antioxidants in N,N-dibutylnitrosamine esophagus and forestomach carcinogenesis of rats. Cancer Res 1987; 47: 2113-2116.
5. HAGIWARA A, TANAKA H, IMAIDA K, et al.: Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Jpn J Cancer Res 1993; 84: 237-245.
6. HASEGAWA R, CABRAL R, HOSHIYA T, et al.: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer 1993; 54: 489-493.
7. HASEGAWA R, FURUKAWA F, TOYODA K, et al.: Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nirtosamine-induced lung carcinogenesis in rats. Jpn J Cancer Res 1990; 81: 871-877.
8. HASEGAWA R, ITO N: Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Food Chem Toxicol 1992; 30: 979-992.
9. HASEGAWA R, TANAKA H, TAMANO S, et al.: Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis 1994; 15: 2567-2573.
10. HIROSE M, HOSHIYA T, AKAGI K, et al.: Effects of green tea catechins in a rat multi-organ carcinogenesis model. Carcinogenesis 1993; 14: 1549-1553.
11. HIROSE M, OZAKI K, TAKABA K, et al.: Modifying effects of the naturally occurring antioxidants γ-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis 1991; 12: 1917-1921.
12. HIROSE M, TANAKA H, TAKAHASHI S, et al.: Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res 1993; 53: 32-37.
13. HIROSE M, YADA H, HAKOI K, et al.: Modification of carcinogenesis by α-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model. Carcinogenesis 1993; 14: 2359-23647
14. HIRSIMAKI P, HIRSIMAKI Y, NIEMINEN L, PAYNE BJ: Tamoxifen induces hepatocellular carcinoma in rat liver: a 1 year study with two antiestrogens. Arch Toxicol 1993; 67: 49-54.
15. HOSHIYA T, HASEGAWA R, HAKOI K, et al.: Enhancement by non-mutagenic pesticides of GST-P positive hepatic foci development initiated with diethylnitrosamine in the rat. Cancer Lett 1993; 72: 59-64.
16. International Agency for Research on Cancer: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Suppl 7, Lyon, IARC Scientific Publications 1987.
17. ISHIDATE M Jr, HARNOIS MC, SOFUNI T: A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res 1988; 195: 151-213.
18. ITO N, HIROSE M, FUKUSHIMA S, et al.: Modifying effects of antioxidants on chemical carcinogenesis. Toxicol Pathol 1986; 14: 315-323.
19. ITO N, IMAIDA K: Strategy of research for cancer-chemoprevention. Teratog Carcinog Mutag 1992; 12: 71-77.
20. ITO N, IMAIDA K, HASEGAWA R, TSUDA H: Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. CRC Crit Rev Toxicol 1989; 19: 385-415.
21. ITO N, SHIRAI T, HASEGAWA R: Medium-term Bioassay for carcinogens. In VAINIO H, MAGEE PN, MCGREGOR DB, MC MICHAEL AJ (eds.): Mechanisms of Carcinogenesis in Risk Assessment; Lyon, IARC 1987, pp 345-380.
22. ITO N, TATEMATSU M, NAKANISHI K, et al.: The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide. Gann 1980; 71: 832-842.
23. ITO N, TSUIDA H, TATEMATSU M, et al.: Enhancing effect of various hepatocarcinogens on induction of pre-neoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis 1988; 9: 387-394.
24. JANG JJ, CHO KJ, LEE YS, et al.: Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model. Carcinogenesis 1991; 12: 691-695.
25. KAHL R: Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens. Toxicology 1984; 33: 185-228.
26. RAO MS, NEMALI MR, USUDA N, et al.: Lack of expression of glutathione-S-transferase P, γ-glutamyl transpeptidase, and α-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators. Cancer Res 1988; 48: 4919-4922.
27. SHIBATA MA, FUKUSHIMA S, TAKAHASHI S, et al.: Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model. Carcinogenesis 1990; 11: 1027-1031.
28. SHIRAI T, IMAIDA K, MASUI T, et al.: Effects of testosterone, dihydrotestosterone and estrogen on 3,2′-dimethyl-4-aminobiphenyl-induced rat prastate carcinogenesis. Int J Cancer 1994; 57: 224-228.
29. SOLT D, FARBER E: New principle for the analysis of chemical carcinogenesis. Nature 1976; 263: 701-703.
30. TAKAHASHI S, HAKOI K, YADA H, et al.: Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats. Carcinosenesis 1992; 13: 1513-1518.
31. TATEMATSU M, MERA Y, ITO N, et al.: Relative merits of immunohistochemical demonstration of placental A, B and C forms of glutathione S-transferase and histochemical demonstration of γ-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis 1985; 6: 1621-1626.
32. TSUDA H, HASEGAWA R, IMAIDA K, et al.: Modifying potential of thirty-one chemicals on the short-term development of γ-glutamyl transpeptidase-positive foci in diethyl-nitrosamine-initiated rat liver. Gann 1984; 75: 876-883.
33. UWAGAWA S, TSUDA H, INOLE T, et al.: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats. Jpn J Cancer Res 1991; 82: 1397-1405.
34. UWAGAWA S, TSUDA H, OZAKI K, et al.: Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model. Jpn J Cancer Res 1992; 83: 812-820.
35. WARD JM, ITO N: Development of new medium-term bioassays for carcinogens. Cancer Res 1988; 48: 5051-5054.
36. WATTENBERG LW: Inhibition of chemical carcinogenesis. J Natl Cancer Inst 1978; 60: 11-18.
37. WEISBURGER JH, JONES RC: Prevention of formation of important mutagens/carcinogens in the human food chain. Basic Life Sci 1990; 52: 105-118.
38. YAMAGUCHI S, HIROSE M, FUKUSHIMA S, et al.: Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res 1989; 49: 6015-6018.
39. YAMAMOTO S, KONISHI Y, MATSUDA T, et al.: Cancer induction by an organic arsenic compound, dimethylarsenic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res 1995; 55: 1271-1276.
40. ZEIGER E: Carcinogenicity of mutagens: predicitive capability of the Salmonella Mutagenesis assay for rodent carcinogenicity. Cancer Res 1987; 47: 1287-1296.