Plasmodium falciparum: Stage specific effects of a selective inhibitor of lactate dehydrogenase

Experimental Parasitology

Volumn 111, Issue 2, 2005, Pages 105-114

  Vivas, Livia ^a   Easton, Anna ^a   Kendrick, Howard ^a   Cameron, Angus ^b   Lavandera, Jose Luis ^c   Barros, David ^c   Gomez De Las Heras, Federico ^c   Brady, R Leo ^b   Croft, Simon L ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c GLAXOSMITHKLINE   (Spain)

Author keywords

Inhibition; Intraerythrocytic cycle; Lactate dehydrogenase; Plasmodium falciparum; Protozoa; Stage specificity

Indexed keywords

ARTESUNATE; CHLOROQUINE; HETEROCYCLIC COMPOUND; LACTATE DEHYDROGENASE; MEFLOQUINE; OXADIAZOLE 4 HYDROXY 1,2,5 OXADIAZOLE 3 CARBOXYLIC ACID; OXADIAZOLE DERIVATIVE; PROTOZOAL PROTEIN; PROTOZOAL RNA; PYRIMETHAMINE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EXPOSURE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TARGETING; ENERGY METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; ERYTHROCYTE; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN VERSUS NONHUMAN DATA; IN VITRO STUDY; MALARIA FALCIPARUM; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCENT DYES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; L-LACTATE DEHYDROGENASE; MICROSCOPY, CONFOCAL; OXADIAZOLES; PHENANTHRIDINES; PLASMODIUM FALCIPARUM; RNA, PROTOZOAN; SPECIES SPECIFICITY;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 24644442580     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exppara.2005.06.007     Document Type: Article

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