Anti-Mycobacterium tuberculosis agents derived from quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 2, 2002, Pages 113-119

  Ortega, Miguel Ángel ^a   Sainz, Yolanda ^a   Montoya, María Elena ^a   Jaso, Andrés ^a   Zarranz, Belén ^a   Aldana, Ignacio ^a   Monge, Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Mycobacterium tuberculosis; Quinoxaline 2 carbonitrile derivatives, in vitro studies, Selectivity Index, synthesis

Indexed keywords

ANTIMYCOBACTERIAL AGENT; QUINOXALINE 2 CARBONITRILE; QUINOXALINE 2 CARBONITRILE 1,4 DI N OXIDE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

EID: 0036170226     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299866     Document Type: Article

References (16)

1. A new class of antituberculosis agents
2. Mechanisms of drug resistance in Mycobacterium tuberculosis
3. New horizons in the treatment of tuberculosis
4. Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs
5. Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides
6. New quinoxaline 1,4-di-N-oxides for treatment of tuberculosis
7. Derivados de la quinoxalina. Nuevos fármacos de potencial utilidad en el tratamiento de la tuberculosis
8. Synthesis and antituberculosis activity of some new 2-quinoxalinecarbonitriles
9. Hypoxia-Selective agents derived from quinoxaline 1,4-di-N-oxides
10. New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents
11. 4-Cyano-2-oxo-1,2,4-oxadiazolo [2,3-a]quinoxaline 5-N-oxides. New synthetic method and reaction with alcohols. Potential cytotoxic activity
12. Síntesis de derivados de quinoxalina sustituidos en posiciones 2, 3, 6 y/ó 7. Nuevos agentes anticancerosos
13. Alkyl nitrite-metal halide deamination reactions. 2. Substitutive deamination of arylamines by alkyl nitrites and cooper(II) halides. A direct and remarkably efficient conversion of arylamines to aryl halides
14. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
15. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions
16. Antimycobacterial activity of new quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives