The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 6971-6978

  Giménez, Diana ^a   Andreu, Cecilia ^a   Olmo, Marcellí del ^a   Varea, Teresa ^a   Diaz, Dolores ^b   Asensio, Gregorio ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Antimicrobial activity; Cationic peptides; Fluorine; Peptide design

Indexed keywords

FLUORINE; HEMOLYTIC AGENT; METHYL GROUP; PEPTIDE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BENZYL COMPOUNDS; CATIONS; DRUG DESIGN; EUKARYOTIC CELLS; FLUORINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748114136     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.027     Document Type: Article

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