Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential β-secretases

Biological Chemistry

Volumn 389, Issue 8, 2008, Pages 1055-1066

  Böhme, Livia ^a   Hoffmann, Torsten ^a   Manhart, Susanne ^a   Wolf, Raik ^a   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

Author keywords

secretase; Alzheimer's disease; Amyloid precursor protein; BACE 1; Cathepsin B; Isoaspartate

Indexed keywords

AMYLOID BETA PROTEIN[8-19]; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; BETA SECRETASE; BETA SECRETASE 1; CATHEPSIN B; CELL EXTRACT; ISOASPARTIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROLYSIS; KINETICS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOID; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE, TUMOR; HUMANS; ISOASPARTIC ACID; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 50849139570     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.125     Document Type: Conference Paper

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