Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1

RNA

Volumn 14, Issue 9, 2008, Pages 1895-1906

  Sibert, Bryan S ^a   Fischel Ghodsian, Nathan ^b   Patton, Jeffrey R ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Modification; Mutagenesis; Pseudouridine; Synthase; tRNA

Indexed keywords

PSEUDOURIDINE; PSEUDOURIDINE SYNTHASE 1; SYNTHETASE; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MUTATION; PRIORITY JOURNAL; RNA STRUCTURE; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BACTERIAL PROTEINS; BINDING SITES; CONSERVED SEQUENCE; HUMANS; HYDRO-LYASES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NUCLEIC ACID CONFORMATION; RNA, TRANSFER; SUBSTRATE SPECIFICITY; TYROSINE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 50649087783     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.984508     Document Type: Article

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