Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

Journal of Fluorine Chemistry

Volumn 129, Issue 9, 2008, Pages 731-742

  Berkowitz, David B ^a   Karukurichi, Kannan R ^a   de la Salud Bea, Roberto ^a   Nelson, David L ^a   McCune, Christopher D ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

19 F NMR spectroscopy; Alpha fluorinated ketones; Enzyme activated inhibitors; Fluoro sugars; Fluorovinyl amino acids; Mechanism based inhibitors; Partition ratio; Suicide substrate; Transition state analogues; Trojan horse inhibitiors

Indexed keywords

EID: 50549098465     PISSN: 00221139     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jfluchem.2008.05.016     Document Type: Review

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