Design, Synthesis, and Biological Activity of a Difluoro-Substituted, Conformationally Rigid Vigabatrin Analogue as a Potent γ-Aminobutyric Acid Aminotransferase Inhibitor

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5292-5293

  Pan, Yue ^a   Qiu, Jian ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; ENZYME INHIBITOR; MERCAPTOETHANOL; UNCLASSIFIED DRUG; VIGABATRIN DERIVATIVE;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; NEUROPHARMACOLOGY; REACTION ANALYSIS; TIME;

4-AMINOBUTYRATE TRANSAMINASE; AMINO ACIDS; CYCLOPENTANES; DRUG DESIGN; FLUORINE; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIGABATRIN;

EID: 0344550407     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034162s     Document Type: Article

References (9)

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