Identification of the active site nucleophile in jack bean α- mannosidase using 5-fluoro-β-L-gulosyl fluoride

Journal of Biological Chemistry

Volumn 273, Issue 4, 1998, Pages 2067-2072

  Howard, Steven ^a,b   He, Shouming ^a,b   Withers, Stephen G ^a,b  

^a Networks of Centres of Excellence   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO BETA GULOSYL FLUORIDE; ALPHA MANNOSIDASE; ASPARTIC ACID; MANNOSIDASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN PROCESSING; QUANTITATIVE DIAGNOSIS; SEQUENCE ANALYSIS; SPECTROMETRY;

ALPHA-MANNOSIDASE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICTYOSTELIUM; FABACEAE; GOLGI APPARATUS; HEXOSES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MANNOSIDASES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PLANTS, MEDICINAL; RATS; SPECTROMETRY, MASS, SECONDARY ION;

MAMMALIA; PHASEOLUS (ANGIOSPERM);

EID: 0031940218     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.4.2067     Document Type: Article

References (29)

1. Goss, P. E., Baker, M. A., Carver, J. P., and Dennis, J. W. (1995) Clin. Cancer Res. 1, 935-944
2. Moremen, K. W., Trimble, R., and Herscovics, A. (1994) Glycobiology 4, 113-125
3. Liao, Y-F., Lai, A., and Moremen, K. W. (1996) J. Biol. Chem. 271, 28348-28358
4. Daniel, P. F., Winchester, B., and Warren, C. D. (1994) Glycobiology 4, 551-566
5. Bennet, J. K., Dembure, P. P., and Elsas, L. J. (1995) Am. J. Med. Genet. 55, 21-26
6. Neufeld, E. F. (1991) Annu. Rev. Biochem. 60, 257-280
7. Henrissat, B., and Bairoch, A. (1996) Biochem. J. 316, 695-696
8. Henrissat, B., and Bairoch, A. (1993) Biochem. J. 293, 781-788
9. Henrissat, B., and Bairoch, A. (1991) Biochem. J. 280, 309-316
10. Lipari, F., and Herscovics, A. (1994) Glycobiology 4, 697-702
11. McCarter, J. D., and Withers, S. G. (1994) Curr. Opin. Struct. Biol. 4, 885-897
12. Sinnott, M. L. (1990) Chem. Rev. 90, 1171-1202
13. Lipari, F., Gour-Salin, B. J., and Herscovics, A. (1995) Biochem. Biophys. Res. Commun. 209, 322-326
14. Howard, S., Braun, C., McCarter, J. D., Moremen, K. W., Liao, Y-F., and Withers, S. G. (1997) Biochem. Biophys. Res. Commun. 238, 896-898
15. Davies, G., and Henrissat, B. (1995) Structure 3, 853-859
16. Gebler, J., Gilkes, N. R., Claeysssens, M., Wilson, D. B., Beguin, P., Wakarchuk, W. W., Kilburn, D. G., Miller, Jr., R. C., Warren, R. A. J., and Withers, S. G. (1992) J. Biol. Chem. 267, 12559-12561
17. Ogawa, S., and Yu, Y. (1995) Bioorg. Med. Chem. 3, 939-943
18. Elbein, A. D., Szumilo, T., Sanford, B. A., Sharpless, K. B., and Adams, C. (1987) Biochemistry 26, 2502-2510
19. Li, Y-T. (1966) J. Biol. Chem. 241, 1010-1012
20. Withers, S. G., Warren, R. A. J., Street, I. P., Rupitz, K., Kempton, J. B., and Aebersold, R. (1990) J. Am. Chem. Soc. 112, 5887-5889
21. Gebler, J. C., Aebersold, R., and Withers, S. G. (1992) J. Biol. Chem. 267, 11126-11130
22. Withers, S. G., and Aebersold, R. (1995) Protein Sci. 4, 361-372
23. McCarter, J. D., and Withers, S. G. (1996) J. Am. Chem. Soc. 118 241-242
24. McCarter, J. D., and Withers, S. G. (1996) J. Biol. Chem. 271 6889-6894
25. Tull, D., Miao, S., Withers, S. G., and Aebersold, R. (1994) Anal. Biochem. 224, 509-514
26. Sharma, S. K., Corrales, G., and Penades, S. (1995) Tetrahedron Lett. 36, 5627-5630
27. Ermert, P., Vasella, A., Weber, M., Rupitz, K., and Withers, S. G. (1993) Carbohydr. Res. 250, 113-128
28. Wentworth, D. F., and Wolfenden, R. (1974) Biochemistry 13, 4715
29. Snaith, S. M. (1975) Biochem. J. 147, 83-90 Eq. 1