Effects of endothelin receptor antagonists on the progression of diabetic nephropathy

Nephron

Volumn 87, Issue 2, 2001, Pages 161-169

  Hocher, Berthold ^a,b,d   Schwarz, Anja ^a,b   Reinbacher, Daniel ^b   Jacobi, Jaqueline ^a   Lun, Andreas ^a   Priem, Friedrich ^a   Bauer, Christian ^b   Neumayer, Hans H ^a   Raschack, Manfred ^c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c Knoll AG   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Diabetic nephropathy; Endothelin receptor antagonists; Streptozotocin

Indexed keywords

ALBUMIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CREATININE; DARUSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; FIBRONECTIN; LAMININ; LU 224332; MATRIX PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE COURSE; DRUG EFFECT; EXTRACELLULAR MATRIX; GLOMERULUS FILTRATION RATE; KIDNEY FIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; RAT; STREPTOZOCIN DIABETES;

ANIMALS; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBRONECTINS; KIDNEY GLOMERULUS; LAMININ; PHENYLPROPIONATES; PROPIONIC ACIDS; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN;

EID: 0035103048     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000045906     Document Type: Article

References (37)

1. Epidemiologic approach to the etiology of type 1 diabetes mellitus and its complications
2. The effect of intensive treatment of diabetes in development and progression of long-term complications in insulin-dependent diabetes mellitus
3. Structural and functional changes in diabetic glomerulopathy
4. The paracrine endothelin system; pathophysiology and implications in clinical medicine
5. Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells
6. Gene expression for endothelin and their receptors in glomeruli of diabetic rats
7. Renal endothelin system in diabetes: Comparison of angiotensin-converting enzyme inhibition and endothelin-A antagonism
8. Elevated urinary excretion of endothelin in insulin-dependent diabetes mellitus of physical exercises
9. Effects of ACE inhibition on spontaneous and insulin-stimulated endothelin secretion: In vitro and in vivo studies
10. Endothelin-1 transgenic mice develop renal cysts, interstitial fibrosis and glomerulosclerosis but not hypertension
11. Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene
12. LU 302 872 and its racemate (LU 224 332) show balanced endothelin-A/B receptor affinity, high oral activity, and inhibit human prostate tissue contractions
13. Urinary protein as measured with a pyrogallol red-molybdate complex manually and in a Hitachi 726 automated analyzer
14. Renal endothelin system in polycystic kidney disease
15. Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes
16. Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli
17. Alteration of growth-related proto-oncogene expression in diabetic glomeruli by a specific endothelin receptor A antagonist
18. Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo
19. Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy
20. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis
21. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease
22. Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats
23. Chronic blockade of endothelin receptors in cirrhotic rats: Hepatic and hemodynamic effects
24. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing
25. Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction
26. Distribution of endothelin receptor subtypes in the rat kidney: Renal and haemodynamic effects of the mixed (A/B) endothelin receptor antagonist bosentan
27. Renoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy
28. Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth
29. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
30. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis
31. Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: Evidence for an endothelin-mediated mechanism
32. Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin
33. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease
34. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
35. Enalapril attenuates increased gene expression of extracellular matrix components in diabetic rats
36. Modification of spontaneous renal lesion of APA hamsters by streptozotocin-induced diabetes
37. An oral endothelin A receptor antagonist blocks collagen synthesis and deposition in advanced liver fibrosis