Dysfunctional renal nitric oxide synthase as a determinant of salt- sensitive hypertension: Mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis

Journal of the American Society of Nephrology

Volumn 11, Issue 5, 2000, Pages 835-846

  Barton, Matthias ^b   Vos, Ingrid ^b   Shaw, Sidney ^b   Boer, Peter ^b   D'Uscio, Livius V ^b   Gröne, Hermann Josef ^b   Rabelink, Ton J ^b   Lattmann, Thomas ^b   Moreau, Pierre ^b   Lüscher, Thomas F ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DARUSENTAN; ENDOTHELIN; ENDOTHELIN 1; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE ACTIVITY; GENE FUNCTION; GLOMERULOSCLEROSIS; KIDNEY CORTEX; KIDNEY HYPERTROPHY; KIDNEY INJURY; KIDNEY MEDULLA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENOVASCULAR HYPERTENSION; VASOCONSTRICTION;

EID: 16744362572     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Morimoto A, Uzu T, Fujii T, Nishimura M, Kuroda S, Nakamura S, Inenaga T, Kimura G: Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet 350: 1734-1737, 1997
2. Arnal JF, Warin L, Michel JB: Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J Clin Invest 90: 647-652, 1992
3. Lüscher TF, Vanhoutte PM: Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8: 344-348, 1986
4. Yokokawa K, Tahara H, Kohno M, Murakawa K, Yasunari K, Nakagawa K, Hamada T, Otani S, Yanagisawa M, Takeda T: Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Ann Intern Med 114: 213-215, 1991
5. Dahl LK, Heine M, Tassinari L: Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 194: 480-482, 1962
6. Simchon S, Manger WM, Carlin RD, Peeters LL, Rodriguez J, Batista D, Brown T, Merchant NB, Jan KM, Chien S: Salt-induced hypertension in Dahl salt-sensitive rats: Hemodynamics and renal responses. Hypertension 13: 612-621, 1989
7. Lüscher TF, Vanhoutte PM, Raij L: Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. Hypertension 9[Suppl III]: 193-197, 1987
8. Hayakawa H, Coffee K, Raij L: Endothelial dysfunction and cardiorenal injury in experimental salt-sensitive hypertension: Effects of antihypertensive therapy. Circulation 96: 2407-2413, 1997
9. A receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy and endothelial dysfunction in salt-sensitive hypertension. Hypertension 31: 499-504, 1998
10. Mattson DL, Lu S, Nakanishi K, Papanek PE, Cowley AW Jr: Effect of chronic renal medullary nitric oxide inhibition on blood pressure. Am J Physiol 266: H1918-H1926, 1994
11. Chatziantoniou C, Boffa JJ, Ardaillou R, Dussaule JC: Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice: Role of endothelin. J Clin Invest 101: 2780-2789, 1998
12. Deng AY, Rapp JR: Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest 95: 2170-2177, 1995
13. Chen PY, Gladish RD, Sanders PW: Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats. Hypertension 31: 918-924, 1998
14. Chen PY, Sanders PW: L-Arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest 88: 1559-1567, 1991
15. Miyata N, Zou AP, Mattson DL, Cowley AW: Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensisitve rats. Am J Physiol 275: R1667-R1673, 1998
16. He H, Kimura S, Fujisawa Y, Tomohiro A, Kiyomoto K, Aki Y, Abe Y: Dietary L-arginine supplementation normalizes regional blood flow in Dahl-Iwai salt-sensitive rats. Am J Hypertens 10: 89S-93S, 1997
17. Mattson DL, Higgins DJ: Influence of dietary sodium intake on renal medullary nitric oxide synthase. Hypertension 27: 688-692, 1996
18. Mattson DL, Maeda CY, Bachmann TD, Cowley AW: Inducible nitric oxide synthase and blood pressure. Hypertension 31: 15-20, 1998
19. Fujihara CK, Michellazzo SM, de Nucci G, Zatz R: Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition. Am J Physiol 266: F697-F705, 1994
20. A receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apoE-deficient mice. Proc Natl Acad Sci USA 95: 14367-14372, 1998
21. A receptor antagonist reverses the inhibitory effect of platelet-derived growth factor on cytokine-induced nitric oxide production. Eur J Pharmacol 365: 119-123, 1999
22. Goligorsky MS, Iijima K, Morgan M, Yanagisawa M, Masaki T, Lin L, Nasjletti A, Kaskel F, Frazer M, Badr KF: Role of endothelin in the development of Dahl hypertension. J Cardiovasc Pharmacol 17[Suppl 7]: S484-S491, 1991
23. Cicila GT, Rapp JP, Bloch KD, Kurtz TW, Pravenec M, Kren V, Hong CC, Quertermous T, Ng SC: Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J Hypertens 12: 643-651, 1994
24. Barton M, Shaw S, d'Uscio LV, Moreau P, Lüscher TF: Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: Role of ETA-receptors for endothelin regulation. Biochem Biophys Res Commun 238: 861-865, 1997
25. Lüscher TF, Raij L, Vanhoutte PM: Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats. Hypertension 9: 157-163, 1987
26. Sterzel RB, Luft FC, Gao Y, Schnermann J, Briggs JP, Ganten D, Waldherr R, Schnabel E, Kriz W: Renal disease and the development of hypertension in salt-sensitive Dahl rats. Kidney Int 33: 1119-1129, 1988
27. Kaasjager KAH, Shaw S, Koomans HA, Rabelink TJ: Role of endothelin receptor subtypes in the systemic and renal responses to endothelin-1 in humans. J Am Soc Nephrol 8: 32-39, 1997
28. Hayakawa H, Raij L: Nitric oxide synthase activity and renal injury in genetic hypertension. Hypertension 31: 266-270, 1998
29. Chen PY, St. John PL, Kirk KA, Abrahamson DR, Sanders PW: Hypertensive nephrosclerosis in the Dahl/Rapp rat: Initial sites of injury and effect of dietary L-arginine supplementation. Lab Invest 68: 174-184, 1993
30. Mohaupt MG, Elzie JL, Ahn KY, Clapp WL, Wilcox CS, Kone BC: Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney. Kidney Int 46: 653-665, 1994
31. Ikeda Y, Saito K, Kim JI, Yokoyama M: Nitric oxide synthase isoform activities in kidney of Dahl salt-sensitive rats. Hypertension 26: 1030-1034, 1995
32. Barri YM, Wilcox CS: Salt intake determines the renal response to L-arginine infusion in normal human subjects. Kidney Int 53: 1299-1304, 1998
33. Waz WR, van Liew JB, Feld LG: Nitric oxide-inhibitory effect of aminoguanidine on renal function in rats. Kidney Blood Press Res 20: 211-217, 1997
34. Wu F, Park F, Cowley AW, Mattson DL: Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney. Am J Physiol 276: F874-F881, 1999
35. Venema RC, Sayegh HS, Kent JD, Harrison DG: Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem 271: 6435-6440, 1996
36. 2+-independent activation of the endothelial nitric oxide synthase. Proc Natl Acad Sci USA 96: 1123-1128, 1999
37. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999
38. Rudd MA, Toolan G, Hope SK, Daumerie GJ, Trolliet MR, Loscalzo J: Salt-dependent increase in blood pressure in mice lacking inducible nitric oxide synthase [Abstract]. Circulation 98: I-4, 1998
39. d'Uscio LV, Barton M, Shaw S, Moreau P, Lüscher TF: Structure and function of small arteries in salt-induced hypertension. Hypertension 30: 905-911, 1997
40. Beck K-F, Mohaupt MG, Sterzel BR, Peters S, Fees H: Endothelin-1 inhibits cytokine-stimulated transcription of inducible nitric oxide synthase in glomerular mesangial cells. Kidney Int 48: 1893-1899, 1995
41. Ikeda U, Yamamoto K, Maeda Y, Shimpo M, Kanbe T, Shimada K: Endothelin-1 inhibits nitric oxide synthesis in vascular smooth muscle cells. Hypertension 29: 65-69, 1997
42. de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR: Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA 85: 9797-9800, 1988
43. Takimoto M, Oda K, Sasaki Y, Okada T: Endothelin-A receptor mediated prostanoid secretion via autocrine and deoxyribonucleic acid synthesis via paracrine signaling in human bronchial epithelial cells. Endocrinology 137: 4542-4550, 1996
44. Pomposiello S, Yang XP, Liu YH, Surakanti M, Rhaleb NE, Sevilla M, Carretero OA: Autacoids mediate coronary vasoconstriction induced by nitric oxide synthesis inhibition. J Cardiovasc Pharmacol 30: 599-606, 1997
45. Wu X, Scholey JW, Sonnenberg H: Renal vascular morphology in male Dahl rats on high-salt diet: Effect of potassium. J Am Soc Nephrol 7: 338-344, 1996
46. Deng AY, Dene H, Pravenec M, Rapp JP: Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 93: 2701-2709, 1994
47. Firth JD, Schricker K, Ratcliffe PJ, Kurtz A: Expression of endothelins 1 and 3 in the rat kidney. Am J Physiol 269: F522-F528, 1995
48. Sventek P, Li JS, Grove K, Deschepper CF, Schiffrin EL: Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats. Hypertension 27: 49-55, 1996
49. Verhagen AM, Rabelink TJ, Braam B, Ogenorth TJ, Grone HJ, Koomans HA, Joles JA: Endothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition. J Am Soc Nephrol 9: 755-762, 1998
50. Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM: Enhanced expression of endothelin-1 gene may cause blood pressure-independent vascular hypertrophy. J Cardiovasc Pharmacol 26: S5-S8, 1995
51. Boulanger C, Luscher TF: Release of endothelin from the porcine aorta: Inhibition by endothelium-derived nitric oxide. J Clin Invest 85: 587-590, 1990
52. Matsumura Y, Hashimoto N, Taira S, Kuro T, Kitano R, Ohkita M, Opgenorth TJ, Takaoka M: Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats. Hypertension 33: 759-765, 1999
53. Fujisaki H, Ito H, Hirata Y, Tanaka M, Hata W, Lin M, Adachi S, Akimoto H, Marumo F, Hiroe M: Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest 96: 1059-1065, 1995
54. Hahn AW, Resink TJ, Scott-Burden T, Powell J, Dohi Y, Buhler FR: Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: A novel autocrine function. Cell Regul 1: 649-659, 1990
55. Alberts GF, Peifley KA, Johns A, Kleha JF, Winkles JA: Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop. J Biol Chem 269: 10112-10118, 1994
56. Sullivan JM: Salt sensitivity: Definition, conception, methodology, and long-term issues. Hypertension 17[Suppl 1]: I61-I68, 1991
57. Cardillo C, Kilcoyne CM, Cannon RO, Panza JA: Attenuation of cyclic nucleotide-mediated smooth muscle relaxation in blacks as a cause of racial differences in vasodilator function. Circulation 99: 90-95, 1999
58. Schmidlin O, Forman A, Tanaka M, Sebastian A, Morris RC: NaCl-induced renal vasoconstriction in salt-sensitive African-Americans: Antipressor and hemodynamic effects of potassium bicarbonate. Hypertension 33: 633-639, 1999
59. Ergul S, Parish DC, Puett D, Ergul A: Racial differences in plasma endothelin-1 concentrations in individuals with essential hypertension. Hypertension 28: 652-655, 1996
60. Rudd MA, Trolliet M, Hope S, Scribner AW, Daumerie G, Toolan G, Cloutier T, Loscalzo J: Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition. Am J Physiol 277: H732-H739, 1999