Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes

Diabetes

Volumn 47, Issue 3, 1998, Pages 450-456

  Benigni, Ariela ^a,b   Colosio, Vittoria ^a   Brena, Claudio ^a   Bruzzi, Isabella ^a   Bertani, Tullio ^a   Remuzzi, Giuseppe ^a  

^a OSPEDALI RIUNITI   (Italy)

^b MARIO NEGRI INST PHARMACOL RES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; GLUCOSE; LISINOPRIL; MESSENGER RNA; N ACETYL 3,3 DIPHENYL DEXTRO ALANYLLEUCYLASPARTYLISOLEUCYLISOLEUCYLTRYPTOPHAN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEINURIA; RAT; STREPTOZOCIN DIABETES;

ALBUMINURIA; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD PRESSURE; COHORT STUDIES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; FOLLOW-UP STUDIES; IN SITU HYBRIDIZATION; KIDNEY; LISINOPRIL; MALE; OLIGOPEPTIDES; PILOT PROJECTS; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; RNA, MESSENGER; TIME FACTORS;

EID: 0031891447     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.3.450     Document Type: Article

References (33)

1. Orisio S, Benigni A, Bruzzi I, Corna D, Perico N, Zoja C, Benatti L, Remuzzi G: Renal endothelin gene expression is increased in remnant kidney and cor-relates with disease progression. Kidney Int 43:354-358,1993
2. Zoja C, Corna D, Bruzzi I, Foglieni C, Bertani T, Remuzzi G, Benigni A: Pas-sive Heymann nephritis: evidence that angiotensin converting enzyme inhi-bition reduces proteinuria and retards renal structural injury. Exp Nephrol 4:213-221,1996
3. Takeda M, Komeyama T, Tsutsui T, Mizusawa T, Katayama Y, Go H, Tamaki M, Hatano A: Changes in urinary excretion of endothelin-1-like immunere-activity before and after unilateral nephrectomy in humans. Nephron 67:180-184,1994
4. Ohta K, Hirata Y, Shichiri M, Kanno K, Emori T, Tomita K, Marumo F: Urinary excretion of endothelin-1 in normal subjects and patients with renal disease. Kidney Int 39:307-311,1991
5. Hocher B, Thöne-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T, Bauer C, Neumayer HH, Schleuning WD, Theur-ing F: Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest 99:1380-1389,1997
6. Hocker B, Liefeldt L, Thone-Reineke C, Orzechowski HD, Distler A, Bauer C, Paul M: Characterization of the renal phenotype of transgenic rats express-ing the human endothelin-2 gene. Hypertension 28:196-201,1996
7. Benigni A, Zoja C, Corna D, Orisio S, Longaretti L, Bertani T, Remuzzi G: A spe-cific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int 44:440-444,1993
8. Benigni A, Zoja C, Corna D, Orisio S, Facchinetti D, Benatti L, Remuzzi G: Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney. Am J Kidney Dis 27:416-423,1996
9. Gomez-Garre D, Largo R, Liu XH, Gutierrez S, Lopez-Armada MJ, Palacios I, Egido J: An orally active ETA/ETB receptor antagonist ameliorates protein-uria and glomerular lesions in rats with proliferative nephritis. Kidney Int 50:962-972, 1996
10. Nakamura T, Ebihara I, Fukui M, Tomino Y, Koide H: Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix com-ponents and growth factors in diabetic glomeruli. Diabetes 44:895-899,1995
11. Zatz R, Dunn BR, Meyer TW, Anderson S, Rennke HR, Brenner BM: Preven-tion of diabetic glomerulopathy by pharmacological amelioration of glomeru-lar capillary hypertension. J Clin Invest 77:1925-1930,1986
12. Kasiske BL, Kalil RSN, Jennie Z, liao M, Keane WF: Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann Intern Med 118:129-138,1993
13. Doherty AM, Cody WL, He JX, DePue PL, Cheng XM, Welch KM, Flynn MA, Reynolds EE, LaDouceur DM, Davis LS, Keiser JA, Haleen SJ: In vitro and in vivo studies with a series of hexapeptide endothelin antagonists. J Cardio-vasc Pharmacol 22:S98-S102, 1993
14. Pfeffer JM, Pfeffer MA, Frohlich ED: Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J Lab Clin Med 78:957-962,1971
15. Read SM, Northcote DH: Minimization of variation in the response to differ-ent proteins of the Coomassie blue G dye-binding assay for protein. Anal Biochem 116:53-64,1981
16. Remuzzi A, Ruggenenti P, Mosconi L, Pata V, Vlberti G, Remuzzi G: Effect of low-dose enalapril on glomerular size-selectivity in human diabetic nephropa-thy. J Nephrol 6:36-43,1993
17. Perico N, Amuchastegui CS, Malanchini B, Bertani T, Remuzzi G: Angiotensin-converting enzyme inhibition and calcium channel blockade both normalize early hyperfiltration in experimental diabetes, but only the former prevents late renal structural damage. Exp Nephrol 2:220-228,1994
18. Highashi A, Peters L: A rapid colorimetric method for the determination of inulin in plasma and urine. J Lab Clin Med 35:475-480,1950
19. Smith HW, Finkelstein N, Aliminosa L: The renal clearances of substitute hippuric acid derivates and other aromatic acids in dog and man. J Clin Invest 24:388-404,1945
20. SAS Institute Inc.: SAS/STAT Users Guide. Version 6. Vol. 2, Ed 4. Cary, NC, SAS Institute Inc., 1989
21. Wallenstein S, Zucker CL, Fleiss JL: Some statistical methods useful in cir-culation research. Circ Res 47:1-9,1980
22. Yamauchi T, Ohnaka K, Takayanagi R, Umeda F, Nawata H: Enhanced secre-tion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. FEBS Lett 267:16-18,1990
23. Inishi Y, Uchida S, Kaname S, Ogata E, Kurokawa K: High ambient glucose down-regulates endothelin-1 receptors in cultured rat mesangial cells (Abstract). J Am Soc Nephrol 2:291,1991
24. Fukui M, Nakamura T, Ebihara I, Osada S, Tomino Y, Masaki TM, Goto K, Furuichi Y, Koide H: Gene expression for endothelins and their receptors in glomeruli of diabetic rats. J Lab Clin Med 122:149-156,1993
25. Pernow J, Boutier JF, Franco-Cereceda A, Lacroix JS, Matran R, Lundberg JM: Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo. Acta Pkysiol Scand 134:573-574,1988
26. Ishimura E, Shouji S, Nishizawa Y, Morii H, Kashgarian M: Regulation of mRNA expression for extracellular matrix (ECM) by cultured rat mesangial cells (MCs) (Abstract). J Am Soc Nephrol 2:546,1991
27. Iwasaki S, Homma T, Matsuda Y, Kon V: Endothelin receptor subtype B medi-ates auto-induction of endothelin-1 in rat mesangial cells. J Clin Invest 270:6997-7003,1995
28. Saijonmaa O, Nyman T, Fyhrquist F: Endothelin-1 stimulates its own synthesis in human endothelial cells. Biochxm Biopkys Res Commun 188:286-291,1992
29. Ong ACM, Jowett TP, Firth JD, Burton S, Karet FE, Fine LG: An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int 48:390-401,1995
30. Bridges CR Jr, Rennke KM, Deen WM, Troy JL, Brenner BM: Reversible hexa dimethrine-induced alterations in glomerular structure and permeability. J Am Soc Nephrol 1:1095-1108,1991
31. Andersen S, Brenner BM: The role of nephron mass and of intraglomerular pressure in initiation and progression of experimental hypertensive-renal disorders. In Hypertension: Pathophysiology, Diagnosis and Management. Loragh JH, Brenner BM, Eds. New York, Raven Press, 1995, p. 1553-1568
32. Anderson S, Rennke HG, Brenner BM: Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with sys-temic hypertension in the rat. J Clin Invest 77:1993-2000,1986
33. Fukui M, Nakamura T, Ebihara I, Makita Y, Osada S, Yomino Y, Koide H: Effects of enalapril on endothelin-1 and growth factor gene expression In dia-betic rat glomeruli. J Lab Clin Med 123:763-768,1994