ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy

Diabetologia

Volumn 46, Issue 6, 2003, Pages 856-868

  Gross, M L ^a   El Shakmak, A ^c   Szabo A ^c   Koch, A ^a   Kuhlmann, A ^b   Munter K ^d   Ritz, E ^a   Amann, K ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d BAYER AG   (Germany)

Author keywords

ACE inhibitor; Diabetic nephropathy; Endothelin receptor blocker; Podocyte damage

Indexed keywords

ALBUMIN; DARUSENTAN; DESMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; FIBRONECTIN; INSULIN ZINC SUSPENSION; PLATELET DERIVED GROWTH FACTOR AB; PROTEIN P27; TRANDOLAPRIL; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFECT; GENETIC TRANSCRIPTION; GEOMETRY; GLOMERULUS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NONHUMAN; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; SMOOTH MUSCLE FIBER; STEREOLOGY; TREATMENT OUTCOME;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; HYPERTROPHY; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; PHENYLPROPIONATES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN;

EID: 0038235832     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1106-8     Document Type: Article

References (41)

1. Kohan DE (1992) Endothelins in the normal and diseased kidney. Am J Kidney Dis 29:2-26
2. Hargrove GM, Dufresne J, Whiteside C, Muruye DA, Wong NC (2000) Diabetes mellitus increases endothelin-1 gene transcription in rat kidney. Kidney Int 58:1534-1545
3. Hiromura K, Haseley LA, Zhang P et al. (2001) Podocyte expression of the CDK-inhibitor P57 during developmnet and disease. Kidney Int 60:2235-2246
4. Pagtalunan ME, Miller PL, Jumping-Eagle S et al. (1979) Podocyte loss and progressive glomerular injury in type 2 diabetes. J Clin Invest 99:342-348
5. Mifsud SA, Allen TJ, Bertram JF et al. (2001) Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade. Diabetologia 44:878-882
6. Pardee AB (1989) G1 events and regulation of cell proliferation. Science 246:603-608
7. Kip1, an inhibitor of cyclin-dependent kinases. Am J Pathol 158:1091-1100
8. Floege J, Hackmann B, Kliem V et al. (1997) Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int 51:220-243
9. Cooper ME (2001) Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 44:1957-1972
10. 2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats. Kidney Int 53:1696-1705
11. Dhein S, Hochreuther S, Spring C aus dem et al. (2000) Long-term effects of the endothelin A receptor antagonist LU135252 and the angiotensin-converting enzyme inhibitor Trandolapril on diabetic angiopathy and nephropathy in a chronic type 1 diabetes mellitus rat model. J Pharmacol Exp Ther 293:351-359
12. Gilbert RE, Cox A, Wu LL et al. (1998) Expression of transforming growth factor β1 and type IV collagen in the renal tubulointerstitium in experimental diabetes. Diabetes 47:414-422
13. Mauer SM, Steffes MW, Brown DM (1979) Animal models of diabetic nephropathy. In: Hamburg J, Gesmir J, Pfrenfeld J, Maxwell MH (eds) Advances in nephrology, vol 8, Year Book Medical Publishers, Chicago London
14. Philipps AO, Baboolal K, Riley S, Groene HJ et al. (2001) Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of non-insulin-dependent diabetes mellitus. Am J Kidney Dis 37:400-410
15. Amann K, Kronenberg G, Gehlen F et al. (1998) Cardiac remodelling in experimental renal failure - an immunohistochemical study. Nephrol Dial Transplant 13:1958-1966
16. Wolf SC, Brehm BR, Gaschler F et al. (1999) Protective effects of endothelin antagonists in chronic renal failure. Nephrol Dial Transplant 4 [14 Suppl]: 29-30
17. El Nahas AM, Bassett AH, Cope GH, Carpentier JE (1991) Role of growth hormone in the development of experimental renal scarring. Kidney Int 40:29-34
18. Ghandi M, Olson JL, Meyer TW (1998) Contribution of tubular injury to loss of remnant kidney function. Kidney Int 54:1157-1165
19. Veniant M, Heudes D, Clozel JP, Bruneval P, Menard J (1994) Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats. Kidney Int 46:421-429
20. Weibel ER (1997) Stereological methods. In: Practical methods for biological morphometry. Academic Press, London, pp 100-167
21. Weibel ER (1997) Stereological methods. In: Theoretical foundation, vol 2. Academic Press, London, pp 56-139
22. Amann K, Koch A, Hofstetter J et al. (2001) Glomerulosclerosis and progression: effect of subantihypertensive doses of α and β blockers. Kidney Int 60:1309-1323
23. Amann K, Nichols C, Toernig J et al. (1996) Effect of ramipril, nifedipine, and moxonidine on glomerular morphology and podocyte structure in experimental renal failure. Nephrol Dial Transplant 11:1003-1011
24. Guo G, Morrisey J, McCracken R, Tolley T, Liapis H, Klahr S (2001) Contribution of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis. Am J Renal Physiol 280: F777-785
25. Amann K, Münter K, Wessels S et al. (2000) Endothelin A receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals. J Am Soc Nephrol 11:1691-1699
26. Amann K, Rump LC, Simonaviciene A et al. (2000) Effects of low dose sympathetic inhibition on glomerulosclerosis and albuminuria in subtotally nephrectomized rats. J Am Soc Nephrol 11:1469-1478
27. Nabokov A, Amann K, Wessels S, Muenter K, Wagner J, Ritz E (1999) Endothelin receptor antagonists influence cardiovascular morphology in uremic rats. Kidney Int 55:512-519
28. Goettsch W, Lattmann T, Amann K et al. (2001) Increased expression of endothelin-1 and nitric oxide synthase isoform II in aging arteries. Implications for atherogenesis. Biochem Biophys Res Comm 280:908-913
29. Lemley KV, Blouch K, Abdullah I et al. (2000) Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus. J Am Soc Nephrol 11:2095-2105
30. Meyer TW, Bennett PH, Nelson RG (1999) Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type 2 diabetes and microalbuminuria. Diabetologia 42:1341-1344
31. Steffes MW, Schmidt D, McCrery R, Basgen JM, the International Study Group (2001) Glomerular cell number in normal subjects and in type 1 diabetic patients. Kidney Int 59:2104-2113
32. Floege J, Bums MW, Alpers CE et al. (1992) Glomerular cell proliferation and PDGF expression proceed glomerulosclerosis in the remnant kidney model. Kidney Int 41:297-309
33. Coimbra TM, Janssen U, Gröne HJ et al. (2000) Early events leading to renal injury in obese Zucker (fatty) rats with type 2 diabetes. Kidney Int 57:167-182
34. Hoshi S, ShuY, Yoshida F et al. (2002) Podocyte injury promotes progressive nephropathy in Zucker diabetic fatty rats. Lab Invest 82:25-35
35. Kip1 in diabetic db/db mouse: Role of hyperglycemia. Kidney Int 53:869-879
36. Nagata M, Yamaguchi Y, KomatsuY, Ito K (1995) Mitosis and the presence of binucleate cells among glomerular podocytes in diseased human kidneys. Nephron 70:68-71
37. KIP1 expression in diabetic BB dp rats. Diabetologia 42:1425-1432
38. Yamada H, Sexton PM, Chai SY, Adam WR, Mendelsohn FA (1990) Angiotensin II receptors in the kidney. Localisation and physiological significance. Am J Hypertens 3:250-255
39. Kriz W, Hackenthal E, Nobiling N, Sakai T, Elger M (1994) A role for podocytes to counteract capillary wall distension. Kidney Int 45:369-376
40. Gloy J, Henger A, Fischer KG et al. (1997) Angiotensin II depolarizes podocytes in the intact glomerulus of the rat. J Clin Invest 99:2772-2781
41. Rebibou JM, He CJ, Delarue F et al. (1992) Functional endothelin 1 receptors on human glomerular podocytes and mesangial cells. Nephrol Dial Transplant 7:288-292