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Volumn 43, Issue 8, 2008, Pages 773-787

Advances in the study of berberine and its derivatives

Author keywords

Berberine; Derivatives; Drug design; Natural product; Structure activity relationship

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; BERBERINE; DRUG DERIVATIVE;

EID: 50249154389     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (46)

References (161)
  • 1
    • 0031689543 scopus 로고    scopus 로고
    • Cyclooxygenase in biology and disease [J]
    • Dubois RN, Abramson SB, Crofford L. Cyclooxygenase in biology and disease [J]. FASEB J, 1998,12:1063-1073.
    • (1998) FASEB J , vol.12 , pp. 1063-1073
    • Dubois, R.N.1    Abramson, S.B.2    Crofford, L.3
  • 2
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice [J]
    • Lefebvre AM, Chen I, Desreumaux P, et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice [J]. Nat Med, 1998,4:1053-1057.
    • (1998) Nat Med , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1    Chen, I.2    Desreumaux, P.3
  • 4
    • 0032985993 scopus 로고    scopus 로고
    • Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells [J]
    • Fukuda K, Hibiya Y, Mutoh M, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells [J]. J Ethnopharmacol, 1999,66:227-233.
    • (1999) J Ethnopharmacol , vol.66 , pp. 227-233
    • Fukuda, K.1    Hibiya, Y.2    Mutoh, M.3
  • 5
    • 0029144134 scopus 로고
    • Topoisomerase poisons: Harnessing the dark side of enzyme mechanism [J]
    • Ammon SJ, Osheroff N. Topoisomerase poisons: harnessing the dark side of enzyme mechanism [J]. Biol Chem, 1995,270:21429-21432.
    • (1995) Biol Chem , vol.270 , pp. 21429-21432
    • Ammon, S.J.1    Osheroff, N.2
  • 6
    • 0035008292 scopus 로고    scopus 로고
    • Inhibition of chemical carcinogenesis by berberine in rats and mice [J]
    • Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice [J]. Pharm Pharmacol, 2001,53:763-768.
    • (2001) Pharm Pharmacol , vol.53 , pp. 763-768
    • Anis, K.V.1    Rajeshkumar, N.V.2    Kuttan, R.3
  • 7
    • 31544478561 scopus 로고    scopus 로고
    • Effect of berberine on proliferation, biosynthesis of macromolecules, cell cycle and induction of intercalation with DNA, dsDNA damage and apoptosis in Ehrlich ascites carcinoma cells [J]
    • Letasiova S, Jantova S, Miko M, et al. Effect of berberine on proliferation, biosynthesis of macromolecules, cell cycle and induction of intercalation with DNA, dsDNA damage and apoptosis in Ehrlich ascites carcinoma cells [J]. J Pharm Pharmacol, 2006,58:263-270.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 263-270
    • Letasiova, S.1    Jantova, S.2    Miko, M.3
  • 8
    • 33645812966 scopus 로고    scopus 로고
    • Down-regulation of cyclin B1 and up-regulation of Weel by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle [J]
    • Lin CC, Lin SY, Chung JG, et al. Down-regulation of cyclin B1 and up-regulation of Weel by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle [J]. Anticancer Res, 2006,26:1097-1104.
    • (2006) Anticancer Res , vol.26 , pp. 1097-1104
    • Lin, C.C.1    Lin, S.Y.2    Chung, J.G.3
  • 9
    • 35548974344 scopus 로고    scopus 로고
    • Mitochondrially targeted effects of berberine on K1735-M2 mouse melanoma cells comparison with direct effects on isolated mitochondrial fractions [J]
    • Pereira GC, Branco AF, Matos JA, et al. Mitochondrially targeted effects of berberine on K1735-M2 mouse melanoma cells comparison with direct effects on isolated mitochondrial fractions [J]. J Pharmacol Exp Ther, 2007,323:636-649.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 636-649
    • Pereira, G.C.1    Branco, A.F.2    Matos, J.A.3
  • 10
    • 26444580293 scopus 로고    scopus 로고
    • Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella Typhi [J]
    • Wu LT, Tsou MF, Ho CC, et al. Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella Typhi [J]. Curr Microbiol, 2005: 51: 255-261.
    • (2005) Curr Microbiol , vol.51 , pp. 255-261
    • Wu, L.T.1    Tsou, M.F.2    Ho, C.C.3
  • 11
    • 0037245022 scopus 로고    scopus 로고
    • Inhibition of tumor induced angiogenesis and matrix metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional Chinese medicine [J]
    • Wartenberg M, Budde P, De Marees M, et al. Inhibition of tumor induced angiogenesis and matrix metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional Chinese medicine [J]. Lab Invest, 2003,83:87-98.
    • (2003) Lab Invest , vol.83 , pp. 87-98
    • Wartenberg, M.1    Budde, P.2    De Marees, M.3
  • 12
    • 0025828218 scopus 로고    scopus 로고
    • Chang KS. Down-regulation of c-Ki-ras gene expression associated with morpho logic differentiation in human embryonal carcinoma cells treated with berberine [J]. Formos Med Assoc, 1991,90:10-14.
    • Chang KS. Down-regulation of c-Ki-ras gene expression associated with morpho logic differentiation in human embryonal carcinoma cells treated with berberine [J]. Formos Med Assoc, 1991,90:10-14.
  • 13
    • 50249134059 scopus 로고    scopus 로고
    • Effect of berberine on gastric precancerous lesions in rats and its mechanism [J]
    • Yao BT, Wu M, Wang B. Effect of berberine on gastric precancerous lesions in rats and its mechanism [J]. Chin J Integr Tradit West Med Gastro-spleen, 2005,13:81-84.
    • (2005) Chin J Integr Tradit West Med Gastro-spleen , vol.13 , pp. 81-84
    • Yao, B.T.1    Wu, M.2    Wang, B.3
  • 14
    • 0033006804 scopus 로고    scopus 로고
    • Berberine induced apoptosis of human leukemia HL-60 cells is associated with downregulation of nucleophosmin/B23 and telomerase activity [J]
    • Wu HL, Hsu CY, Liu WH, et al. Berberine induced apoptosis of human leukemia HL-60 cells is associated with downregulation of nucleophosmin/B23 and telomerase activity [J]. Int J Cancer, 1999,81:923-929.
    • (1999) Int J Cancer , vol.81 , pp. 923-929
    • Wu, H.L.1    Hsu, C.Y.2    Liu, W.H.3
  • 15
    • 0242654822 scopus 로고    scopus 로고
    • Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids [J]
    • Barreto MC, Pinto RE, Arrabaca JD, et al. Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids [J]. Toxicol Lett, 2003,146:37-47.
    • (2003) Toxicol Lett , vol.146 , pp. 37-47
    • Barreto, M.C.1    Pinto, R.E.2    Arrabaca, J.D.3
  • 16
    • 33845219352 scopus 로고    scopus 로고
    • Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells [J]
    • Jantova S, Cipak L, Letasiova S. Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells [J]. Toxicol In Vitro, 2007,21:25-31.
    • (2007) Toxicol In Vitro , vol.21 , pp. 25-31
    • Jantova, S.1    Cipak, L.2    Letasiova, S.3
  • 17
    • 0346724714 scopus 로고    scopus 로고
    • The anti-inflammatory potential of berberine in vitro and in vivo [J]
    • Kuo CL, Chi CW, Uu TY. The anti-inflammatory potential of berberine in vitro and in vivo [J]. Cancer Lett, 2004,203:127-137.
    • (2004) Cancer Lett , vol.203 , pp. 127-137
    • Kuo, C.L.1    Chi, C.W.2    Uu, T.Y.3
  • 18
    • 4944248618 scopus 로고    scopus 로고
    • Berberine inhibits HIF-1 alpha expression via enhanced proteolysis [J]
    • Lin S, Tsai SC, Lee CC, et al. Berberine inhibits HIF-1 alpha expression via enhanced proteolysis [J]. Mol Pharmacol, 2004,66:612-619.
    • (2004) Mol Pharmacol , vol.66 , pp. 612-619
    • Lin, S.1    Tsai, S.C.2    Lee, C.C.3
  • 19
    • 33745001816 scopus 로고    scopus 로고
    • Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2 [J]
    • Peng PL, Hsieh YS, Wang CJ. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2 [J]. Toxicol Appl Pharmacol, 2006,214:8-15.
    • (2006) Toxicol Appl Pharmacol , vol.214 , pp. 8-15
    • Peng, P.L.1    Hsieh, Y.S.2    Wang, C.J.3
  • 20
    • 0037052649 scopus 로고    scopus 로고
    • Anticachectic effects of the natural herb rhizoma coptidis and berberine on mice bearing colon 26/clone 20 adenecarcinoma [J]
    • Fizuka N, Hazama S, Yoshimura K, et al. Anticachectic effects of the natural herb rhizoma coptidis and berberine on mice bearing colon 26/clone 20 adenecarcinoma [J]. Int J Cancer, 2002,99:286-291.
    • (2002) Int J Cancer , vol.99 , pp. 286-291
    • Fizuka, N.1    Hazama, S.2    Yoshimura, K.3
  • 21
    • 18644377310 scopus 로고    scopus 로고
    • Antitumor experiment research of berberine [J]
    • Huang LQ, Xu CF, Zhou SW, et al. Antitumor experiment research of berberine [J]. Chin Pharmacol Bull, 1997,13:189.
    • (1997) Chin Pharmacol Bull , vol.13 , pp. 189
    • Huang, L.Q.1    Xu, C.F.2    Zhou, S.W.3
  • 22
    • 50249105593 scopus 로고    scopus 로고
    • Five cases of diabetes treated by hydrochloricberberine [J]
    • Tan HM. Five cases of diabetes treated by hydrochloricberberine [J]. Her Med, 1996,15:297.
    • (1996) Her Med , vol.15 , pp. 297
    • Tan, H.M.1
  • 23
    • 50249101991 scopus 로고    scopus 로고
    • Clinical investigation for 44 cases of gerontism type II diabetes treated by berberine [J]. Jiangxi
    • Chen HF, Cai FN. Clinical investigation for 44 cases of gerontism type II diabetes treated by berberine [J]. Jiangxi J Tradit Chin Med, 1999,30:19.
    • (1999) J Tradit Chin Med , vol.30 , pp. 19
    • Chen, H.F.1    Cai, F.N.2
  • 24
    • 50249188654 scopus 로고    scopus 로고
    • Clinical investigation of type II diabetes treated by berberine [J]. Hubei
    • Zhang M, Yu FH, Ding XP. Clinical investigation of type II diabetes treated by berberine [J]. Hubei J Tradit Chin Med, 2001,23:16.
    • (2001) J Tradit Chin Med , vol.23 , pp. 16
    • Zhang, M.1    Yu, F.H.2    Ding, X.P.3
  • 25
    • 50249122989 scopus 로고    scopus 로고
    • Clinical observation on berberine in reducing blood glucose [J]. Hebei Med J
    • 24:93-94
    • Huo Y, Cen DZ, Tu ZL. Clinical observation on berberine in reducing blood glucose [J]. Hebei Med J, 2002,24:93-94.
    • (2002)
    • Huo, Y.1    Cen, D.Z.2    Tu, Z.L.3
  • 26
    • 47549117841 scopus 로고    scopus 로고
    • Clinical study on improvement of type II diabetes mellitus complicated with fatty liver treated by berberine [J]
    • Wei J, Wu JD, Jiang JD. Clinical study on improvement of type II diabetes mellitus complicated with fatty liver treated by berberine [J]. Chin J Integr Tradit West Med Liver Dis, 2004,14:334-336.
    • (2004) Chin J Integr Tradit West Med Liver Dis , vol.14 , pp. 334-336
    • Wei, J.1    Wu, J.D.2    Jiang, J.D.3
  • 27
    • 34547096433 scopus 로고    scopus 로고
    • Comparision of glycoconsumption for Hep G2 cells treated by dimethylbiguanide, troglitazone and berberine [J]
    • Yin J, Hu RM, Cen MD, et al. Comparision of glycoconsumption for Hep G2 cells treated by dimethylbiguanide, troglitazone and berberine [J]. Chin J Endocrinol Metab, 2002,18:488-489.
    • (2002) Chin J Endocrinol Metab , vol.18 , pp. 488-489
    • Yin, J.1    Hu, R.M.2    Cen, M.D.3
  • 28
    • 0036833480 scopus 로고    scopus 로고
    • Effects of berberine on glucose metabolism in vitro [J]
    • Yin J, Hu R, Chen M, et al. Effects of berberine on glucose metabolism in vitro [J]. Metabolism, 2002,51:1439-1443.
    • (2002) Metabolism , vol.51 , pp. 1439-1443
    • Yin, J.1    Hu, R.2    Chen, M.3
  • 29
    • 33845803826 scopus 로고    scopus 로고
    • Mechanism research of glucose transport of adipocyte treated by berberine [J]
    • Zhou LB, Chen MD, Song HD. Mechanism research of glucose transport of adipocyte treated by berberine [J]. Chin J Endocrinol Metab, 2003,19:479-482.
    • (2003) Chin J Endocrinol Metab , vol.19 , pp. 479-482
    • Zhou, L.B.1    Chen, M.D.2    Song, H.D.3
  • 30
    • 33750519660 scopus 로고    scopus 로고
    • Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK [J]
    • Cheng Z, Pang T, Gu M. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK [J]. Biochim Biophys Acta, 2006,1760:1682-1689.
    • (2006) Biochim Biophys Acta , vol.1760 , pp. 1682-1689
    • Cheng, Z.1    Pang, T.2    Gu, M.3
  • 31
    • 33846845952 scopus 로고    scopus 로고
    • Berberine stimulates glucose transport through a mechanism distinct from insulin [J]
    • Zhou L, Yang Y, Wang X. Berberine stimulates glucose transport through a mechanism distinct from insulin [J]. Metabolism, 2007,56:405-412.
    • (2007) Metabolism , vol.56 , pp. 405-412
    • Zhou, L.1    Yang, Y.2    Wang, X.3
  • 32
    • 50249156280 scopus 로고    scopus 로고
    • Prospect of insulin resistance and insulin resistance syndrome [J]
    • Li XJ. Prospect of insulin resistance and insulin resistance syndrome [J]. Chin J Endocrinol Metab, 2000,16:274-275.
    • (2000) Chin J Endocrinol Metab , vol.16 , pp. 274-275
    • Li, X.J.1
  • 33
    • 0035039227 scopus 로고    scopus 로고
    • Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys [J]
    • Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys [J]. Diabetes, 2001,50:1126-1133.
    • (2001) Diabetes , vol.50 , pp. 1126-1133
    • Hotta, K.1    Funahashi, T.2    Bodkin, N.L.3
  • 34
    • 20844454370 scopus 로고    scopus 로고
    • Effects of berberine on adiponectin mRNA expression in 3T3-L1 adipocyte [J]
    • Gu Wei, Zeng WH, Hu HY. Effects of berberine on adiponectin mRNA expression in 3T3-L1 adipocyte [J]. China J Chin Mater Med, 2005,30:286-288.
    • (2005) China J Chin Mater Med , vol.30 , pp. 286-288
    • Wei, G.1    Zeng, W.H.2    Hu, H.Y.3
  • 35
    • 33749336146 scopus 로고    scopus 로고
    • Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states [J]
    • Yun SL, Woo SK, Kang HK, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states [J]. Diabetes, 2006,55:2256-2265.
    • (2006) Diabetes , vol.55 , pp. 2256-2265
    • Yun, S.L.1    Woo, S.K.2    Kang, H.K.3
  • 36
    • 36049038044 scopus 로고    scopus 로고
    • Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes [J]
    • Kim SH, Shin EJ, Kim ED, et al. Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes [J]. Biol Pharm Bull, 2007,30:2120-2125.
    • (2007) Biol Pharm Bull , vol.30 , pp. 2120-2125
    • Kim, S.H.1    Shin, E.J.2    Kim, E.D.3
  • 37
    • 33747079990 scopus 로고    scopus 로고
    • Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway [J]
    • Huang C, Zhang Y, Gong Z. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway [J]. Biochem Biophys Res Commun, 2006,348:571-578.
    • (2006) Biochem Biophys Res Commun , vol.348 , pp. 571-578
    • Huang, C.1    Zhang, Y.2    Gong, Z.3
  • 38
    • 4444305180 scopus 로고    scopus 로고
    • Inhibitory action of berberine on glucose absorption [J]
    • Pan GY, Wang GJ, Sun JG, et al. Inhibitory action of berberine on glucose absorption [J]. Acta Pharm Sin , 2003,38:911-914.
    • (2003) Acta Pharm Sin , vol.38 , pp. 911-914
    • Pan, G.Y.1    Wang, G.J.2    Sun, J.G.3
  • 39
    • 0041379639 scopus 로고    scopus 로고
    • The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption [J]
    • Pan GY, Huang ZJ, Wang GJ, et al. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption [J]. Planta Med, 2003,69:632-636.
    • (2003) Planta Med , vol.69 , pp. 632-636
    • Pan, G.Y.1    Huang, Z.J.2    Wang, G.J.3
  • 40
    • 0033761633 scopus 로고    scopus 로고
    • Miglitol, assessment of its role in the treatment of patients with diabetes mellitus [J]
    • Campbell LK, Baker DE, Campbell RK. Miglitol, assessment of its role in the treatment of patients with diabetes mellitus [J]. Ann Pharmacother, 2000, 34:1291-1301.
    • (2000) Ann Pharmacother , vol.34 , pp. 1291-1301
    • Campbell, L.K.1    Baker, D.E.2    Campbell, R.K.3
  • 41
    • 50249162349 scopus 로고    scopus 로고
    • Inhibition of five Chinese traditional medicines for proteinglycosylation without enzyme [J]
    • Duan YJ, Wang SY, San LYZ, et al. Inhibition of five Chinese traditional medicines for proteinglycosylation without enzyme [J]. Chin J Diabetes, 1998,6:227-229.
    • (1998) Chin J Diabetes , vol.6 , pp. 227-229
    • Duan, Y.J.1    Wang, S.Y.2    San, L.Y.Z.3
  • 42
    • 0037145924 scopus 로고    scopus 로고
    • Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids [J]
    • Lee HS. Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids [J]. J Agric Food Chem, 2002,50:7013-7016.
    • (2002) J Agric Food Chem , vol.50 , pp. 7013-7016
    • Lee, H.S.1
  • 44
    • 0035131796 scopus 로고    scopus 로고
    • Li BX, Yang BF, Zhou J, et al. Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes [J]. Acta Pharmacol Sin, 2001,22:125-131.
    • Li BX, Yang BF, Zhou J, et al. Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes [J]. Acta Pharmacol Sin, 2001,22:125-131.
  • 45
    • 0032754008 scopus 로고    scopus 로고
    • Blocking L-calcium current by 1-tetrahydropalmatine in single ventricular myocyte of guinea pigs [J]
    • Huang K, Dai GZ, Li XH, et al. Blocking L-calcium current by 1-tetrahydropalmatine in single ventricular myocyte of guinea pigs [J]. Acta Pharmacol Sin, 1999,20:907-911.
    • (1999) Acta Pharmacol Sin , vol.20 , pp. 907-911
    • Huang, K.1    Dai, G.Z.2    Li, X.H.3
  • 46
    • 0030734061 scopus 로고    scopus 로고
    • Ionic mechanism responsible for prolongation of cardiac action-potential duration by berberine [J]
    • Wang YX, Zheng YM. Ionic mechanism responsible for prolongation of cardiac action-potential duration by berberine [J]. J Cardiovasc Pharmacol, 1997,30:214-222.
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 214-222
    • Wang, Y.X.1    Zheng, Y.M.2
  • 47
    • 0029022435 scopus 로고
    • Comparative studies on the characteristics of dopamine receptors in different vascular systems [J]
    • Zhu L, Zhao RR, Wang WZ. Comparative studies on the characteristics of dopamine receptors in different vascular systems [J]. Chin J Physiol Sci, 1995,11:79-86.
    • (1995) Chin J Physiol Sci , vol.11 , pp. 79-86
    • Zhu, L.1    Zhao, R.R.2    Wang, W.Z.3
  • 48
    • 23444446417 scopus 로고    scopus 로고
    • Effects of tetrahydroberberine on peripheral vascular dopamine DA_1 and DA_2 receptor subtypes [J]
    • Zhang WF, Zhi JM, Guo W. Effects of tetrahydroberberine on peripheral vascular dopamine DA_1 and DA_2 receptor subtypes [J]. China J Chin Mater Med, 2000,25:497-500.
    • (2000) China J Chin Mater Med , vol.25 , pp. 497-500
    • Zhang, W.F.1    Zhi, J.M.2    Guo, W.3
  • 49
    • 0000006534 scopus 로고    scopus 로고
    • Effect of berberine hydrochloride on muscarinic receptors [J]
    • Wang WY, Chen KM, Guan YY, et al. Effect of berberine hydrochloride on muscarinic receptors [J]. Acta Pharm Sin, 1999,34:260-263.
    • (1999) Acta Pharm Sin , vol.34 , pp. 260-263
    • Wang, W.Y.1    Chen, K.M.2    Guan, Y.Y.3
  • 50
    • 34247629729 scopus 로고    scopus 로고
    • Effect of berberine on left ventricular remodeling in renovascular hypertensive rats [J]
    • Zhao HP, Hong Y, Xie JD, et al. Effect of berberine on left ventricular remodeling in renovascular hypertensive rats [J]. Acta Pharm Sin, 2007,42:336-341.
    • (2007) Acta Pharm Sin , vol.42 , pp. 336-341
    • Zhao, H.P.1    Hong, Y.2    Xie, J.D.3
  • 51
    • 50249141573 scopus 로고    scopus 로고
    • Influence of berberine on cardiovascular function in rats with HCM induced by L-thyroxin [J]
    • Zhao HP, Hong Y, Xie JD, et al. Influence of berberine on cardiovascular function in rats with HCM induced by L-thyroxin [J]. J Beijing Univ Tradit Chin Med, 2007,30:105-108.
    • (2007) J Beijing Univ Tradit Chin Med , vol.30 , pp. 105-108
    • Zhao, H.P.1    Hong, Y.2    Xie, J.D.3
  • 52
    • 32144461376 scopus 로고    scopus 로고
    • Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury [J]
    • Liang KW, Ting CT, Yin SC. Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury [J]. Biochem Pharmacol, 2006,71:806-817.
    • (2006) Biochem Pharmacol , vol.71 , pp. 806-817
    • Liang, K.W.1    Ting, C.T.2    Yin, S.C.3
  • 53
    • 33646479753 scopus 로고    scopus 로고
    • Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model [J]
    • Lee S, Lim HJ, Park HY. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model [J]. Atherosclerosis, 2006,186:29-37.
    • (2006) Atherosclerosis , vol.186 , pp. 29-37
    • Lee, S.1    Lim, H.J.2    Park, H.Y.3
  • 54
    • 0037251184 scopus 로고    scopus 로고
    • Werner N, Nickening G. AT1 receptor in atherosclerosis: biological effects including growth, angiogenesis, and apoptosis [J]. Eur Heart J Supplem, 2003, 5 (Suppl A):9-13.
    • Werner N, Nickening G. AT1 receptor in atherosclerosis: biological effects including growth, angiogenesis, and apoptosis [J]. Eur Heart J Supplem, 2003, 5 (Suppl A):9-13.
  • 55
    • 50249093626 scopus 로고    scopus 로고
    • The Effect of berberine on the angiotensin II receptor type 1 in the prevention of carotid artery atherosclerosis in rabbits [J]
    • He GH, Zhou L, Wang YF. The Effect of berberine on the angiotensin II receptor type 1 in the prevention of carotid artery atherosclerosis in rabbits [J]. Chin J Arterioscler, 2006,14:1035-1037.
    • (2006) Chin J Arterioscler , vol.14 , pp. 1035-1037
    • He, G.H.1    Zhou, L.2    Wang, Y.F.3
  • 56
    • 0028491913 scopus 로고
    • Study of platelet aggregation affected by 8 classical recipes in rabbit [J]
    • Chu ZL, Huang CG, Xu ZP. Study of platelet aggregation affected by 8 classical recipes in rabbit [J]. Chin J Integr Tradit Chin West Med, 1994,14:510-512.
    • (1994) Chin J Integr Tradit Chin West Med , vol.14 , pp. 510-512
    • Chu, Z.L.1    Huang, C.G.2    Xu, Z.P.3
  • 57
    • 0037092641 scopus 로고    scopus 로고
    • Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells [J]
    • Huang CG, Chu ZL, Wei SJ, et al. Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells [J]. Thromb Res, 2002,106:223-227.
    • (2002) Thromb Res , vol.106 , pp. 223-227
    • Huang, C.G.1    Chu, Z.L.2    Wei, S.J.3
  • 58
    • 34547098072 scopus 로고    scopus 로고
    • Research on the effective improvement of hyperlipidemia by berberine [J]
    • Wei J, Jiang JD, Wu JD. Research on the effective improvement of hyperlipidemia by berberine [J]. Chin J Diabetes, 2005,13:49-51.
    • (2005) Chin J Diabetes , vol.13 , pp. 49-51
    • Wei, J.1    Jiang, J.D.2    Wu, J.D.3
  • 59
    • 50249181502 scopus 로고
    • Fifty-nine cases of hyperlipemia treated by berberine [J]
    • Gou YH, Zong YX. Fifty-nine cases of hyperlipemia treated by berberine [J]. PLA Med, 1995, 2:35-36.
    • (1995) PLA Med , vol.2 , pp. 35-36
    • Gou, Y.H.1    Zong, Y.X.2
  • 60
    • 19944374769 scopus 로고    scopus 로고
    • Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins [J]
    • Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins [J]. Nat Med, 2004, 10:1344-1351.
    • (2004) Nat Med , vol.10 , pp. 1344-1351
    • Kong, W.1    Wei, J.2    Abidi, P.3
  • 61
    • 50249175745 scopus 로고    scopus 로고
    • Effects of berberine on lipid metabolism in rats [J]
    • Yin J, Chen MD, Yang Y, et al. Effects of berberine on lipid metabolism in rats [J]. Acta Univ Med Second Shanghai, 2003,23:28-30.
    • (2003) Acta Univ Med Second Shanghai , vol.23 , pp. 28-30
    • Yin, J.1    Chen, M.D.2    Yang, Y.3
  • 62
    • 50249138962 scopus 로고    scopus 로고
    • Effect and mechanisms of berberine on hyperlipidemic and insulin resistant rats [J]
    • He MK, Lu FE, Wang KF, et al. Effect and mechanisms of berberine on hyperlipidemic and insulin resistant rats [J]. Chin J Hosp Pharm, 2004, 24:389-391.
    • (2004) Chin J Hosp Pharm , vol.24 , pp. 389-391
    • He, M.K.1    Lu, F.E.2    Wang, K.F.3
  • 63
    • 33744804815 scopus 로고    scopus 로고
    • Inhibition of lipid synthesis through activation of AMP kinase: An additional mechanism for the hypolipidemic effects of berberine [J]
    • Brusq JM, Ancellin N, Grondin P, et al. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine [J]. J Lipid Res, 2006,47:1281-1289.
    • (2006) J Lipid Res , vol.47 , pp. 1281-1289
    • Brusq, J.M.1    Ancellin, N.2    Grondin, P.3
  • 64
    • 26244452375 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine [J]
    • Abidi P, Zhou Y, Jiang JD, et al. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine [J]. Arterioscler Thromb Vasc Biol, 2005,25:2170-2176.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2170-2176
    • Abidi, P.1    Zhou, Y.2    Jiang, J.D.3
  • 65
    • 34548591723 scopus 로고    scopus 로고
    • Berberine-induced LDLR up-regulation involves JNK pathway [J]
    • Lee S, Lim HJ, Park JH, et al. Berberine-induced LDLR up-regulation involves JNK pathway [J]. Biochem Biophys Res Commun, 2007,362:853-857.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 853-857
    • Lee, S.1    Lim, H.J.2    Park, J.H.3
  • 66
    • 26244433390 scopus 로고    scopus 로고
    • Effects of berberine on IL-1 or tumour necrosis factor induced polymorphonuclear leucocyte-endothelium adhesion [J]
    • Hao Y, Qiu QY, Wang JJ, et al. Effects of berberine on IL-1 or tumour necrosis factor induced polymorphonuclear leucocyte-endothelium adhesion [J]. Chin J Pathophysiol, 2000,16:585-587.
    • (2000) Chin J Pathophysiol , vol.16 , pp. 585-587
    • Hao, Y.1    Qiu, Q.Y.2    Wang, J.J.3
  • 67
    • 0029563102 scopus 로고
    • Inhibition of in vitro lymphocyte transformation by the isoquinoline alkaloid berberine [J]
    • Ckless K, Schlottfeldt JL, Pasqual M, et al. Inhibition of in vitro lymphocyte transformation by the isoquinoline alkaloid berberine [J]. J Pharm Pharmacol, 1995,47:1029-1031.
    • (1995) J Pharm Pharmacol , vol.47 , pp. 1029-1031
    • Ckless, K.1    Schlottfeldt, J.L.2    Pasqual, M.3
  • 68
    • 42649105371 scopus 로고    scopus 로고
    • Xu LH, Liu Y, He XH. Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes [J]. Cellul Mol Immunol, 2005, 2:295-301.
    • Xu LH, Liu Y, He XH. Inhibitory effects of berberine on the activation and cell cycle progression of human peripheral lymphocytes [J]. Cellul Mol Immunol, 2005, 2:295-301.
  • 69
    • 0442309637 scopus 로고    scopus 로고
    • Effect of berberine on lymphocyte endothelium adhesion and adhesion molecules expression [J]
    • Hao Y, Qiu QY, Wu J, et al. Effect of berberine on lymphocyte endothelium adhesion and adhesion molecules expression [J]. Chin J Immunol, 1999,15:523-525.
    • (1999) Chin J Immunol , vol.15 , pp. 523-525
    • Hao, Y.1    Qiu, Q.Y.2    Wu, J.3
  • 70
    • 34548206790 scopus 로고    scopus 로고
    • Berberine suppresses inflammatory agents-induced interleukin-lbeta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells [J]
    • Lee CH, Chen JC, Hsiang CY, et al. Berberine suppresses inflammatory agents-induced interleukin-lbeta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells [J]. Pharmacol Res, 2007,56:193-201.
    • (2007) Pharmacol Res , vol.56 , pp. 193-201
    • Lee, C.H.1    Chen, J.C.2    Hsiang, C.Y.3
  • 71
    • 34447641235 scopus 로고    scopus 로고
    • Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells [J]
    • Ko YJ, Lee JS, Park BC, et al. Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells [J]. Vascul Pharmacol, 2007,47:189-196.
    • (2007) Vascul Pharmacol , vol.47 , pp. 189-196
    • Ko, Y.J.1    Lee, J.S.2    Park, B.C.3
  • 72
    • 33846224631 scopus 로고    scopus 로고
    • Effect of berberine on monocyte chemotactic protein-1 and cytokine-induced neutrophil chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis [J]
    • Cui HS, Hayasaka S, Zheng LS, et al. Effect of berberine on monocyte chemotactic protein-1 and cytokine-induced neutrophil chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis [J]. Ophthalmic Res, 2007,39:32-93.
    • (2007) Ophthalmic Res , vol.39 , pp. 32-93
    • Cui, H.S.1    Hayasaka, S.2    Zheng, L.S.3
  • 73
    • 50249085810 scopus 로고    scopus 로고
    • Discussion of immunifaction mechanism for antiinflammation of berberine [J]. Northwest
    • Jiang JY, Liu F. Discussion of immunifaction mechanism for antiinflammation of berberine [J]. Northwest Pharm J, 1997,12:59-60.
    • (1997) Pharm J , vol.12 , pp. 59-60
    • Jiang, J.Y.1    Liu, F.2
  • 74
    • 33748773901 scopus 로고    scopus 로고
    • Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice [J]
    • Li F, Wang HD, Lu DX. Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice [J]. Acta Pharmacol Sin, 2006,27:1199-1205.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1199-1205
    • Li, F.1    Wang, H.D.2    Lu, D.X.3
  • 75
    • 0036189651 scopus 로고    scopus 로고
    • Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane [J]
    • Severina II, Muntyan MS, Lewis K, et al. Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane [J]. IUBMB Life, 2001,52:321-324.
    • (2001) IUBMB Life , vol.52 , pp. 321-324
    • Severina, I.I.1    Muntyan, M.S.2    Lewis, K.3
  • 76
    • 0036188966 scopus 로고    scopus 로고
    • Stage specificity of plasmodium falciparum telomerase and its inhibition by berberine [J]
    • Sriwilaijareon N, Petmitr S, Mutirangura A, et al. Stage specificity of plasmodium falciparum telomerase and its inhibition by berberine [J]. Parasitol Int, 2002,51:99-103.
    • (2002) Parasitol Int , vol.51 , pp. 99-103
    • Sriwilaijareon, N.1    Petmitr, S.2    Mutirangura, A.3
  • 77
    • 34249880498 scopus 로고    scopus 로고
    • Anti-HIV-1 activities of four berberine compounds in vitro [J]
    • Yang LM, Wang RR, Li JJ. Anti-HIV-1 activities of four berberine compounds in vitro [J]. Chin J Nat Med, 2007,5:225-228.
    • (2007) Chin J Nat Med , vol.5 , pp. 225-228
    • Yang, L.M.1    Wang, R.R.2    Li, J.J.3
  • 79
    • 33847197936 scopus 로고    scopus 로고
    • Antiviral activity of berberine and related compounds against human cytomegalovirus [J]
    • Hayashi K, Minoda K, Nagaoka Y. Antiviral activity of berberine and related compounds against human cytomegalovirus [J]. Bioorg Med Chem Lett, 2007,17:1562-1564.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 1562-1564
    • Hayashi, K.1    Minoda, K.2    Nagaoka, Y.3
  • 80
    • 1642493153 scopus 로고
    • Protective effect of berberine on rat hippocampus against cerebral ischemia [J]
    • Wei YZ, Yao ZB, Yuan QF. Protective effect of berberine on rat hippocampus against cerebral ischemia [J]. Chin J Neuroanatomy, 1995, 11:315-322.
    • (1995) Chin J Neuroanatomy , vol.11 , pp. 315-322
    • Wei, Y.Z.1    Yao, Z.B.2    Yuan, Q.F.3
  • 81
    • 17044392450 scopus 로고
    • Protective effects of berberine on rat cerebral ischemia [J]
    • Shi YJ, Wu JF, Liu TP. Protective effects of berberine on rat cerebral ischemia [J]. J Nanjing Med Coll, 1995,15:256-259.
    • (1995) J Nanjing Med Coll , vol.15 , pp. 256-259
    • Shi, Y.J.1    Wu, J.F.2    Liu, T.P.3
  • 82
    • 50249092544 scopus 로고    scopus 로고
    • Effect of berberine on protooncogene c-fos expression induced by focal cerebral ischemia in rats [J]
    • Wu JF, Wang P, Pan XX. Effect of berberine on protooncogene c-fos expression induced by focal cerebral ischemia in rats [J]. Chin J Clin Pharmacol Ther, 1998,3:1-4.
    • (1998) Chin J Clin Pharmacol Ther , vol.3 , pp. 1-4
    • Wu, J.F.1    Wang, P.2    Pan, X.X.3
  • 83
    • 50249118887 scopus 로고    scopus 로고
    • Effects of geniposide, baicalin, berberine on rat cerebral microvascular endothelial cell adhesion molecules expression for ischemic-reperfusion injury by hypoxia/reoxigenation [C]
    • Yuan ZZ. Effects of geniposide, baicalin, berberine on rat cerebral microvascular endothelial cell adhesion molecules expression for ischemic-reperfusion injury by hypoxia/reoxigenation [C]. Beijing: Beijing University of Traditional Chinese Medicine, 2005.
    • (2005) Beijing: Beijing University of Traditional Chinese Medicine
    • Yuan, Z.Z.1
  • 84
    • 33645542616 scopus 로고    scopus 로고
    • Berberry extract reduces neuronal damage and N-methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia [J]
    • Yoo KY, Hwang IK, Lim BO, et al. Berberry extract reduces neuronal damage and N-methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia [J]. Biol Pharm Bull, 2006,29:623-628.
    • (2006) Biol Pharm Bull , vol.29 , pp. 623-628
    • Yoo, K.Y.1    Hwang, I.K.2    Lim, B.O.3
  • 86
    • 0029174128 scopus 로고
    • Effects of berberine on platelet aggregation and plasma levels of txb2 and 6-keto-pgfla in rats with reveksible middle cerebral arteky occlusion [J]
    • Wu JF, Liu TP. Effects of berberine on platelet aggregation and plasma levels of txb2 and 6-keto-pgfla in rats with reveksible middle cerebral arteky occlusion [J]. Acta Pharm Sin, 1995,30:98-102.
    • (1995) Acta Pharm Sin , vol.30 , pp. 98-102
    • Wu, J.F.1    Liu, T.P.2
  • 87
    • 33751509301 scopus 로고    scopus 로고
    • Berberine alters the processing of Alzheimer' s amyloid precursor protein to decrease Abeta secretion [J]
    • Asai M, Iwata N, Yoshikawa A. Berberine alters the processing of Alzheimer' s amyloid precursor protein to decrease Abeta secretion [J]. Biochem Biophys Res Commun, 2007,352:498-502.
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 498-502
    • Asai, M.1    Iwata, N.2    Yoshikawa, A.3
  • 88
    • 0041309915 scopus 로고    scopus 로고
    • Potentiation of nerve growth factor-induced neunte outgrowth in PC12 cells by a coptidis rhizoma extract and protoberberine alkaloids [J]
    • Koji S, Keisuke O, Hideki T, et al. Potentiation of nerve growth factor-induced neunte outgrowth in PC12 cells by a coptidis rhizoma extract and protoberberine alkaloids [J]. Biosci Biotechnol Biochem, 2002,66:2491-2494.
    • (2002) Biosci Biotechnol Biochem , vol.66 , pp. 2491-2494
    • Koji, S.1    Keisuke, O.2    Hideki, T.3
  • 89
    • 33845602246 scopus 로고    scopus 로고
    • Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-lbeta and inducible nitric oxide synthase in the rat model of Alzheimer's disease [J]
    • Zhu FQ, Qian CY. Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-lbeta and inducible nitric oxide synthase in the rat model of Alzheimer's disease [J]. BMC Neurosci, 2006,7:78.
    • (2006) BMC Neurosci , vol.7 , pp. 78
    • Zhu, F.Q.1    Qian, C.Y.2
  • 90
    • 33750612044 scopus 로고    scopus 로고
    • 8-Hydroxydihydrochelery-thrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L [J]
    • Cho KM, Yoo ID, Kim WG. 8-Hydroxydihydrochelery-thrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L [J]. Biol Pharm Bull, 2006,29:2317-2320.
    • (2006) Biol Pharm Bull , vol.29 , pp. 2317-2320
    • Cho, K.M.1    Yoo, I.D.2    Kim, W.G.3
  • 91
    • 50249155180 scopus 로고    scopus 로고
    • New pharmacological effects of tetrahydroprotoberberines on dopamine receptor [J]
    • Jin GZ, Zhou QT, Chen LJ. New pharmacological effects of tetrahydroprotoberberines on dopamine receptor [J]. Bull Natl Sci Foundat China, 2000, 300.
    • (2000) Bull Natl Sci Foundat China , pp. 300
    • Jin, G.Z.1    Zhou, Q.T.2    Chen, L.J.3
  • 92
    • 0031047027 scopus 로고    scopus 로고
    • + current in acutely dissociated rat hippocampal CA1 pyramidal neurons [J]
    • + current in acutely dissociated rat hippocampal CA1 pyramidal neurons [J]. Neurosci Lett, 1997,222:115-118.
    • (1997) Neurosci Lett , vol.222 , pp. 115-118
    • Wu, J.1    Jin, G.Z.2
  • 93
    • 34547484479 scopus 로고    scopus 로고
    • Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride [J]
    • Kulkarni SK, Dhir A. Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride [J]. Eur J Pharmacol, 2007,569:77-83.
    • (2007) Eur J Pharmacol , vol.569 , pp. 77-83
    • Kulkarni, S.K.1    Dhir, A.2
  • 94
    • 0038721145 scopus 로고    scopus 로고
    • Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model [J]
    • Li H, Miyahara T, Tezuka Y, et al. Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model [J]. Biol Pharm Bull, 2003, 26:110-111.
    • (2003) Biol Pharm Bull , vol.26 , pp. 110-111
    • Li, H.1    Miyahara, T.2    Tezuka, Y.3
  • 95
    • 33847719032 scopus 로고    scopus 로고
    • Effects of berberine from Cortex Phellodendri Chinensis on osteoporosis in ovariectomized rats [J]
    • Nian H, Xu LL, Ma MH, et al. Effects of berberine from Cortex Phellodendri Chinensis on osteoporosis in ovariectomized rats [J]. Pharm Care Res, 2007,7:41-44.
    • (2007) Pharm Care Res , vol.7 , pp. 41-44
    • Nian, H.1    Xu, L.L.2    Ma, M.H.3
  • 96
    • 39049191428 scopus 로고    scopus 로고
    • Effect of berberine on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosum [J]
    • Tan Y, Tang Q, Hu BR, et al. Effect of berberine on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosum [J]. Natl J Androl, 2004,10:890-893.
    • (2004) Natl J Androl , vol.10 , pp. 890-893
    • Tan, Y.1    Tang, Q.2    Hu, B.R.3
  • 97
    • 22444448645 scopus 로고    scopus 로고
    • Modulation action of berberine on NO-cGMP signal pathway in isolated corpus cavernosum smooth muscle [J]
    • Tan Y, Tang Q, Hu BR, et al. Modulation action of berberine on NO-cGMP signal pathway in isolated corpus cavernosum smooth muscle [J]. Chin Pharmacol Bull, 2005,21:435-440.
    • (2005) Chin Pharmacol Bull , vol.21 , pp. 435-440
    • Tan, Y.1    Tang, Q.2    Hu, B.R.3
  • 98
    • 39049184867 scopus 로고    scopus 로고
    • Effects of berberine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro [J]
    • Tan Y, Tang Q, Hu BR. Effects of berberine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro [J]. Natl J Androl, 2005, 11:406-408.
    • (2005) Natl J Androl , vol.11 , pp. 406-408
    • Tan, Y.1    Tang, Q.2    Hu, B.R.3
  • 99
    • 0032421418 scopus 로고    scopus 로고
    • Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbit [J]
    • Chiou WF, James C, Chen CF. Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbit [J]. British J Pharmacol, 1998,125:1677-1684.
    • (1998) British J Pharmacol , vol.125 , pp. 1677-1684
    • Chiou, W.F.1    James, C.2    Chen, C.F.3
  • 100
    • 50249106158 scopus 로고    scopus 로고
    • Mechanisms for protection of berberine against LPS-induced acute lung injury in mice [J]
    • Zhang HQ, Zou P, Wang HD. Mechanisms for protection of berberine against LPS-induced acute lung injury in mice [J]. Chin J Pathophysiol, 2007,23:495-499.
    • (2007) Chin J Pathophysiol , vol.23 , pp. 495-499
    • Zhang, H.Q.1    Zou, P.2    Wang, H.D.3
  • 101
    • 27744444956 scopus 로고    scopus 로고
    • Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice [J]
    • Pan LR, Tang Q, Fu Q. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice [J]. Acta Pharmacol Sin, 2005,26:1334-1338.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1334-1338
    • Pan, L.R.1    Tang, Q.2    Fu, Q.3
  • 102
    • 27744437536 scopus 로고    scopus 로고
    • Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells [J]
    • Hsiang CY, Wu SL, Cheng SE. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells [J]. J Biomed Sci, 2005,12:791-801.
    • (2005) J Biomed Sci , vol.12 , pp. 791-801
    • Hsiang, C.Y.1    Wu, S.L.2    Cheng, S.E.3
  • 103
    • 0036460068 scopus 로고    scopus 로고
    • Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver [J]
    • Hwang JM, Wang CJ, Chou FP, et al. Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver [J]. Arch Toxicol, 2002,76:664-670.
    • (2002) Arch Toxicol , vol.76 , pp. 664-670
    • Hwang, J.M.1    Wang, C.J.2    Chou, F.P.3
  • 104
    • 0029161558 scopus 로고
    • Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium [J]
    • Misík V, Bezáková L, Máleková L, et al, Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium [J]. Planta Med, 1995,61:372-373.
    • (1995) Planta Med , vol.61 , pp. 372-373
    • Misík, V.1    Bezáková, L.2    Máleková, L.3
  • 105
    • 0035261496 scopus 로고    scopus 로고
    • Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c [J]
    • Choi DS, Kim SJ, Jung MY. Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c [J]. Biosci Biotechnol Biochem, 2001,65:452-455.
    • (2001) Biosci Biotechnol Biochem , vol.65 , pp. 452-455
    • Choi, D.S.1    Kim, S.J.2    Jung, M.Y.3
  • 106
    • 0035019158 scopus 로고    scopus 로고
    • Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats [J]
    • Xu X, Malavé A. Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats [J]. Pharmacol Toxicol, 2001,88:232-237.
    • (2001) Pharmacol Toxicol , vol.88 , pp. 232-237
    • Xu, X.1    Malavé, A.2
  • 107
    • 0035919898 scopus 로고    scopus 로고
    • DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats [J]
    • Chang CK, Lin MT. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats [J]. Neurosci Lett, 2001,307:163-166.
    • (2001) Neurosci Lett , vol.307 , pp. 163-166
    • Chang, C.K.1    Lin, M.T.2
  • 108
    • 84871511285 scopus 로고    scopus 로고
    • Study on differential expression of genes associated with metabolism by cDNA microarry in rat liver treated with berberine chloride [J]
    • Xin HW, Wu XC, Li Q. Study on differential expression of genes associated with metabolism by cDNA microarry in rat liver treated with berberine chloride [J]. Chin Pharmacol Bull, 2004,20:1122-1126.
    • (2004) Chin Pharmacol Bull , vol.20 , pp. 1122-1126
    • Xin, H.W.1    Wu, X.C.2    Li, Q.3
  • 109
    • 50249111356 scopus 로고    scopus 로고
    • Study on pharmacological action mechanism of berberine chloride by genome-wide expression profiling of saccharomyces cerevisi [J]
    • Zhang Y, Zhang L, Zhou YM. Study on pharmacological action mechanism of berberine chloride by genome-wide expression profiling of saccharomyces cerevisi [J]. Chin J Integr Tradit Chin West Med, 2003,23:48-53.
    • (2003) Chin J Integr Tradit Chin West Med , vol.23 , pp. 48-53
    • Zhang, Y.1    Zhang, L.2    Zhou, Y.M.3
  • 110
    • 0029281557 scopus 로고
    • 1H NMR investigation of the interaction of berberine and sanguinarine with DNA [J]
    • 1H NMR investigation of the interaction of berberine and sanguinarine with DNA [J]. Indian J Biochem Biophys, 1995,32:74-77.
    • (1995) Indian J Biochem Biophys , vol.32 , pp. 74-77
    • Saran, A.1    Srivastava, S.2    Coutinho, E.3
  • 111
    • 0030753506 scopus 로고    scopus 로고
    • Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs [J]
    • Pilch DS, YuC, Makhey D, et al. Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs [J]. Biochemistry, 1997,36:12542-12553.
    • (1997) Biochemistry , vol.36 , pp. 12542-12553
    • Pilch, D.S.1    Yu, C.2    Makhey, D.3
  • 112
    • 0032242329 scopus 로고    scopus 로고
    • Interaction of the antitumour alkaloid coralyne with duplex deoxyribonucleic acid structures; spectroscopic and viscometric studies [J]
    • Pal S, Kumar GS, Debnath D, et al. Interaction of the antitumour alkaloid coralyne with duplex deoxyribonucleic acid structures; spectroscopic and viscometric studies [J]. Indian J Biochem Biophys, 1998,35:321-332.
    • (1998) Indian J Biochem Biophys , vol.35 , pp. 321-332
    • Pal, S.1    Kumar, G.S.2    Debnath, D.3
  • 113
    • 0037245495 scopus 로고    scopus 로고
    • Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT) (2) [J]
    • Mazzini S, Bellucci MC, Mondelli R, et al. Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT) (2) [J]. Bioorg Med Chem, 2003,11:505-514.
    • (2003) Bioorg Med Chem , vol.11 , pp. 505-514
    • Mazzini, S.1    Bellucci, M.C.2    Mondelli, R.3
  • 114
    • 13444292203 scopus 로고    scopus 로고
    • Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA [J]
    • Chen WH, Qin Y, Cai Z, et al. Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA [J]. Bioorg Med Chem, 2005,13:1859-1866.
    • (2005) Bioorg Med Chem , vol.13 , pp. 1859-1866
    • Chen, W.H.1    Qin, Y.2    Cai, Z.3
  • 115
    • 33847723808 scopus 로고    scopus 로고
    • DNA-binding affinities and sequence specificities of protoberberine alkaloids and their demethylated derivatives: A comparative study [J]
    • Qin Y, Chen WH, Pang JY. DNA-binding affinities and sequence specificities of protoberberine alkaloids and their demethylated derivatives: a comparative study [J]. Chem Biodivers, 2007,4:145-153.
    • (2007) Chem Biodivers , vol.4 , pp. 145-153
    • Qin, Y.1    Chen, W.H.2    Pang, J.Y.3
  • 116
    • 33846450257 scopus 로고    scopus 로고
    • RNA binding small molecules : Studies on t-RNA binding by cytotoxic plant alkaloids berberine, palmatine and the comparison to ethidium [J]
    • Islam MM, Sinha R, Kumar GS. RNA binding small molecules : studies on t-RNA binding by cytotoxic plant alkaloids berberine, palmatine and the comparison to ethidium [J]. Biophys Chem, 2007,125:508-520.
    • (2007) Biophys Chem , vol.125 , pp. 508-520
    • Islam, M.M.1    Sinha, R.2    Kumar, G.S.3
  • 117
    • 50249089929 scopus 로고    scopus 로고
    • Fluorescence characteristics of the interaction between cycle DNA plasmid pUC118 and ligand berberine [J]
    • Zhao LP, Huang DY. Fluorescence characteristics of the interaction between cycle DNA plasmid pUC118 and ligand berberine [J]. J Shanxi Univ -Natl Sci Edit, 2005,28:83-86.
    • (2005) J Shanxi Univ -Natl Sci Edit , vol.28 , pp. 83-86
    • Zhao, L.P.1    Huang, D.Y.2
  • 118
    • 33750167675 scopus 로고    scopus 로고
    • Molecular aspects on the specific interaction of cytotoxic plant alkaloid palmatine to poly(A) [J]
    • Giri P, Hossain M, Kumar GS. Molecular aspects on the specific interaction of cytotoxic plant alkaloid palmatine to poly(A) [J]. Int J Biol Macromol, 2006,39:210-221.
    • (2006) Int J Biol Macromol , vol.39 , pp. 210-221
    • Giri, P.1    Hossain, M.2    Kumar, G.S.3
  • 119
    • 33645218155 scopus 로고    scopus 로고
    • Interaction study between double-stranded DNA and berberine using capillary zone electrophoresis [J]
    • Wu JF, Chen LX, Luo GA. Interaction study between double-stranded DNA and berberine using capillary zone electrophoresis [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006,833:158-164.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.833 , pp. 158-164
    • Wu, J.F.1    Chen, L.X.2    Luo, G.A.3
  • 120
    • 18144406519 scopus 로고    scopus 로고
    • Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities [J]
    • Chen WH, Pang JY, Qin Y, et al. Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities [J]. Bioorg Med Chem Lett, 2005,15:2689-2692.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 2689-2692
    • Chen, W.H.1    Pang, J.Y.2    Qin, Y.3
  • 121
    • 33646576228 scopus 로고    scopus 로고
    • Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA [J]
    • Long YH, Bai LP, Qin Y. Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA [J]. Bioorg Med Chem, 2006,14:4670-4676.
    • (2006) Bioorg Med Chem , vol.14 , pp. 4670-4676
    • Long, Y.H.1    Bai, L.P.2    Qin, Y.3
  • 122
    • 32044461141 scopus 로고    scopus 로고
    • Natural and synthetic G-quadruplex interactive berberine derivatives [J]
    • Franceschin M, Rossetti L, D'Ambrosio A, er al. Natural and synthetic G-quadruplex interactive berberine derivatives [J]. Bioorg Med Chem Lett, 2006,16:1707-1711.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1707-1711
    • Franceschin, M.1    Rossetti, L.2    D'Ambrosio, A.3    er al4
  • 123
    • 34249706308 scopus 로고    scopus 로고
    • Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA [J]
    • Gornall KC, Samosorn S, Talib J. Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA [J]. Rapid Commun Mass Spectrom, 2007,21:1759-1766.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 1759-1766
    • Gornall, K.C.1    Samosorn, S.2    Talib, J.3
  • 124
    • 0037386852 scopus 로고    scopus 로고
    • Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures [J]
    • Das S, Kumar GS, Ray A, et al, Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures [J]. J Biomol Struct Dyn, 2003,20:703-714.
    • (2003) J Biomol Struct Dyn , vol.20 , pp. 703-714
    • Das, S.1    Kumar, G.S.2    Ray, A.3
  • 125
    • 33751552402 scopus 로고    scopus 로고
    • Characterization of enantioselective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods [J]
    • Su X, Qin F, Kong L, et al. Characterization of enantioselective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2007,845:174-179.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.845 , pp. 174-179
    • Su, X.1    Qin, F.2    Kong, L.3
  • 126
    • 33751511999 scopus 로고    scopus 로고
    • Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry [J]
    • Zuo F, Nakamura N, Akao T. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry [J]. Drug Metab Dispos, 2006,34:2064-2072.
    • (2006) Drug Metab Dispos , vol.34 , pp. 2064-2072
    • Zuo, F.1    Nakamura, N.2    Akao, T.3
  • 128
    • 0036797498 scopus 로고    scopus 로고
    • The involvement of P-glycoprotein in berberine absorption [J]
    • Pan GY, Wang GJ, Liu XD, et al. The involvement of P-glycoprotein in berberine absorption [J]. Pharmacol Toxicol, 2002,91:193-197.
    • (2002) Pharmacol Toxicol , vol.91 , pp. 193-197
    • Pan, G.Y.1    Wang, G.J.2    Liu, X.D.3
  • 130
    • 33646358216 scopus 로고    scopus 로고
    • Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate [J]
    • Hong Z, Fan G, Le J. Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate [J]. Biopharm Drug Dispos, 2006,27:111-117.
    • (2006) Biopharm Drug Dispos , vol.27 , pp. 111-117
    • Hong, Z.1    Fan, G.2    Le, J.3
  • 131
    • 0034000975 scopus 로고    scopus 로고
    • Wang GJ, Gao L, Yang P, et al. Pharmacokinetics and pharmacodynamics of 7-(4-chlorbenzyl)-7, 8, 13, 13a-tetrahydroberberine chloride in dogs [J]. Chin J Pharmacol Toxicol, 2000, 14:72-75.
    • Wang GJ, Gao L, Yang P, et al. Pharmacokinetics and pharmacodynamics of 7-(4-chlorbenzyl)-7, 8, 13, 13a-tetrahydroberberine chloride in dogs [J]. Chin J Pharmacol Toxicol, 2000, 14:72-75.
  • 132
    • 0037702353 scopus 로고    scopus 로고
    • Feng NP, Zhang ZX, An DK, et al. Analysis of the metabolite of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in rabbit [J]. Acta Pharm Sin, 2001,36:137-139.
    • Feng NP, Zhang ZX, An DK, et al. Analysis of the metabolite of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in rabbit [J]. Acta Pharm Sin, 2001,36:137-139.
  • 133
    • 0031961558 scopus 로고    scopus 로고
    • Feng NP, Zhang ZX, An DK, et al. Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat [J]. Eur J Drug Metab Pharmacokinet, 1998,23:41-44.
    • Feng NP, Zhang ZX, An DK, et al. Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat [J]. Eur J Drug Metab Pharmacokinet, 1998,23:41-44.
  • 134
    • 50249185445 scopus 로고    scopus 로고
    • Zeng MY, Li JM. Toxic reaction report of berberine [J]. Tradit Chin Drug Res Clin Pharmacol, 1995,6:47-48.
    • Zeng MY, Li JM. Toxic reaction report of berberine [J]. Tradit Chin Drug Res Clin Pharmacol, 1995,6:47-48.
  • 135
    • 0030876993 scopus 로고    scopus 로고
    • Antimicrobial activity of some 13-alkyl substituted protoberberinium salts [J]
    • Iwasa K, Kamigauchi M, Sugiura M, et al. Antimicrobial activity of some 13-alkyl substituted protoberberinium salts [J]. Planta Med, 1997,63:196-198.
    • (1997) Planta Med , vol.63 , pp. 196-198
    • Iwasa, K.1    Kamigauchi, M.2    Sugiura, M.3
  • 136
    • 0032421319 scopus 로고    scopus 로고
    • Structure activity relationships of protoberberines having antimicrobial activity [J]
    • Iwasa K, Nanba H, Lee DU, et al. Structure activity relationships of protoberberines having antimicrobial activity [J]. Planta Med, 1998,64:748-751.
    • (1998) Planta Med , vol.64 , pp. 748-751
    • Iwasa, K.1    Nanba, H.2    Lee, D.U.3
  • 137
    • 0031661329 scopus 로고    scopus 로고
    • Antimicrobial activity of 8-alkayl and 8-phenyl-substituted berberines and their 12-bromo derivatives [J]
    • Iwasa K, Lee DU, Kang SI, et al. Antimicrobial activity of 8-alkayl and 8-phenyl-substituted berberines and their 12-bromo derivatives [J]. J Nat Prod, 1998,61:1150-1153.
    • (1998) J Nat Prod , vol.61 , pp. 1150-1153
    • Iwasa, K.1    Lee, D.U.2    Kang, S.I.3
  • 138
    • 33745158365 scopus 로고    scopus 로고
    • Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents [J]
    • Park KD, Lee JH, Kim SH, et al. Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents [J]. Bioorg Med Chem Lett, 2006,16:3913-3916.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 3913-3916
    • Park, K.D.1    Lee, J.H.2    Kim, S.H.3
  • 139
    • 34250835962 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of 8-alkylberberine derivatives with a long aliphatic chain [J]
    • Yang Y, Ye XL, Li XG. Synthesis and antimicrobial activity of 8-alkylberberine derivatives with a long aliphatic chain [J]. Planta Med, 2007,73:602-604.
    • (2007) Planta Med , vol.73 , pp. 602-604
    • Yang, Y.1    Ye, X.L.2    Li, X.G.3
  • 140
    • 0034048073 scopus 로고    scopus 로고
    • Antimicrobial activity of 9-O-acyl-and 9-O-benzyl-substituted berberrubines [J]
    • Hong SW, Kim SH, Jeun JA, et al. Antimicrobial activity of 9-O-acyl-and 9-O-benzyl-substituted berberrubines [J]. Planta Med, 2000,66:361-363.
    • (2000) Planta Med , vol.66 , pp. 361-363
    • Hong, S.W.1    Kim, S.H.2    Jeun, J.A.3
  • 141
    • 0036215315 scopus 로고    scopus 로고
    • Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives [J]
    • Kim SH, Lee SJ, Lee JH, et al. Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine derivatives [J]. Planta Med, 2002,68:277-281.
    • (2002) Planta Med , vol.68 , pp. 277-281
    • Kim, S.H.1    Lee, S.J.2    Lee, J.H.3
  • 143
    • 0031915772 scopus 로고    scopus 로고
    • Antimalarial activity and structure activity relationships of protoberberine alkaloids [J]
    • Iwasa K, Kim HS, Wataya Y, et al. Antimalarial activity and structure activity relationships of protoberberine alkaloids [J]. Eur J Med Chem, 1998,33:65-69.
    • (1998) Eur J Med Chem , vol.33 , pp. 65-69
    • Iwasa, K.1    Kim, H.S.2    Wataya, Y.3
  • 144
    • 0034526130 scopus 로고    scopus 로고
    • In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids [J]
    • Colin WW, Sarah JM, Peter FR, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids [J]. J Nat Prod, 2000,63:1638-1640.
    • (2000) J Nat Prod , vol.63 , pp. 1638-1640
    • Colin, W.W.1    Sarah, J.M.2    Peter, F.R.3
  • 145
    • 0033399245 scopus 로고    scopus 로고
    • Structure activity relationships of quaternary protoberberine alkaloids having antimalarial activity [J]
    • Iwasa K, Nishiyama Y, Ichimaru M, et al. Structure activity relationships of quaternary protoberberine alkaloids having antimalarial activity [J]. Eur J Med Chem, 1999,34:1077-1083.
    • (1999) Eur J Med Chem , vol.34 , pp. 1077-1083
    • Iwasa, K.1    Nishiyama, Y.2    Ichimaru, M.3
  • 146
    • 11344286238 scopus 로고    scopus 로고
    • Zhang C, Lin Y, Hua WY. Synthesis of chiral compounds of 4-chlorobenzyl tetrahydroberberine chloride [J]. J China Pharm Univ, 2004,35:393-3%.
    • Zhang C, Lin Y, Hua WY. Synthesis of chiral compounds of 4-chlorobenzyl tetrahydroberberine chloride [J]. J China Pharm Univ, 2004,35:393-3%.
  • 147
    • 30044434913 scopus 로고    scopus 로고
    • Synthesis and antiarrhythmic activity of protoberberine quaternary ammonium compounds [J]
    • Zhang C, Huang WL. Synthesis and antiarrhythmic activity of protoberberine quaternary ammonium compounds [J]. J China Pharm Univ, 2003, 34:7-12.
    • (2003) J China Pharm Univ , vol.34 , pp. 7-12
    • Zhang, C.1    Huang, W.L.2
  • 148
    • 33645462974 scopus 로고    scopus 로고
    • Synthesis and antiarrhythmic activity of some tetrahydroherberine quaternary ammonium compounds [J]
    • Wang RF, Xu GY, Hua WY, et al. Synthesis and antiarrhythmic activity of some tetrahydroherberine quaternary ammonium compounds [J]. Chin J Med Chem, 1996,6:243-248.
    • (1996) Chin J Med Chem , vol.6 , pp. 243-248
    • Wang, R.F.1    Xu, G.Y.2    Hua, W.Y.3
  • 149
    • 50249161365 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of CPU-86017 and its optical derivates on mouse blood pressure and rat aortic contraction [J]
    • Feng Y, Yang L, Dai DZ. Comparison of inhibitory effects of CPU-86017 and its optical derivates on mouse blood pressure and rat aortic contraction [J]. Chin J Clin Pharmacol Ther, 2007, 12:23-27.
    • (2007) Chin J Clin Pharmacol Ther , vol.12 , pp. 23-27
    • Feng, Y.1    Yang, L.2    Dai, D.Z.3
  • 150
    • 33746172071 scopus 로고    scopus 로고
    • Berberine potently inhibits protein tyrosine phosphatase 1B: Investigation by docking simulation and experimental validation [J]
    • Bustanji Y, Taha MO, Yousef AM, et al. Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validation [J]. J Enzyme Inhib Med Chem, 2006,21:163-171.
    • (2006) J Enzyme Inhib Med Chem , vol.21 , pp. 163-171
    • Bustanji, Y.1    Taha, M.O.2    Yousef, A.M.3
  • 151
    • 31344458055 scopus 로고    scopus 로고
    • Synthesis and antihyperglycemic evaluation of various protoberberine derivatives [J]
    • Bian X, He L, Yang G. Synthesis and antihyperglycemic evaluation of various protoberberine derivatives [J]. Bioorg Med Chem Lett, 2006,16:1380-1383.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1380-1383
    • Bian, X.1    He, L.2    Yang, G.3
  • 152
    • 0034908257 scopus 로고    scopus 로고
    • In vitro cytotoxicity of the protoberberine-type alkaloids [J]
    • Iwasa K, Moriyasu M, Yamori T, et al. In vitro cytotoxicity of the protoberberine-type alkaloids [J]. J Nat Prod, 2001,64:896-898.
    • (2001) J Nat Prod , vol.64 , pp. 896-898
    • Iwasa, K.1    Moriyasu, M.2    Yamori, T.3
  • 153
    • 0033884111 scopus 로고    scopus 로고
    • Structural modification of berberine alkaloids in relation to cytotoxic activity in vitro [J]
    • Orfila L, Rodríguez M, Colman T, et al. Structural modification of berberine alkaloids in relation to cytotoxic activity in vitro [J]. J Nat Prod, 2000,71:449-456.
    • (2000) J Nat Prod , vol.71 , pp. 449-456
    • Orfila, L.1    Rodríguez, M.2    Colman, T.3
  • 154
    • 0028818003 scopus 로고
    • Inhibitors of DNA topoisomerase I and II isolated from the coptis rhizomes [J]
    • Kobayashi Y, Yamashita Y, Fujii N, et al. Inhibitors of DNA topoisomerase I and II isolated from the coptis rhizomes [J]. Planta Med, 1995,61:414-418.
    • (1995) Planta Med , vol.61 , pp. 414-418
    • Kobayashi, Y.1    Yamashita, Y.2    Fujii, N.3
  • 155
    • 0034489654 scopus 로고    scopus 로고
    • The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition [J]
    • Krishnan P, Bastow KF. The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition [J]. Anticancer Drug Des, 2000,15:255-264.
    • (2000) Anticancer Drug Des , vol.15 , pp. 255-264
    • Krishnan, P.1    Bastow, K.F.2
  • 156
    • 34248594357 scopus 로고    scopus 로고
    • Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids [J]
    • Qin Y, Pang JY, Chen WH. Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids [J]. Chem Biodivers, 2007,4:481-487.
    • (2007) Chem Biodivers , vol.4 , pp. 481-487
    • Qin, Y.1    Pang, J.Y.2    Chen, W.H.3
  • 157
    • 34250782208 scopus 로고    scopus 로고
    • 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA [J]
    • Zhang WJ, Ou TM, Lu YJ. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA [J]. Bioorg Med Chem, 2007,15:5493-5501.
    • (2007) Bioorg Med Chem , vol.15 , pp. 5493-5501
    • Zhang, W.J.1    Ou, T.M.2    Lu, Y.J.3
  • 158
    • 0030988237 scopus 로고    scopus 로고
    • Characteristics of tetrahydroprotoberberines on dopamine D1 and D2 receptors in calf striatum [J]
    • Guo X, Wang LM, Liu J, et al. Characteristics of tetrahydroprotoberberines on dopamine D1 and D2 receptors in calf striatum [J]. Acta Pharmacol Sin, 1997,18:225-230.
    • (1997) Acta Pharmacol Sin , vol.18 , pp. 225-230
    • Guo, X.1    Wang, L.M.2    Liu, J.3
  • 159
    • 0030978544 scopus 로고    scopus 로고
    • Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat [J]
    • Wang LM, Zhang XX, Jin GZ. Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat [J]. Acta Pharmacol Sin, 1997,18:143-146.
    • (1997) Acta Pharmacol Sin , vol.18 , pp. 143-146
    • Wang, L.M.1    Zhang, X.X.2    Jin, G.Z.3
  • 160
    • 50249154649 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships for tetrahydroprotoberberines to interact with the dopamine 2 receptor [J]
    • Fu XC, Hu YZ, Zhou QT. Quantitative structure-activity relationships for tetrahydroprotoberberines to interact with the dopamine 2 receptor [J]. Chin J Med Chem, 1999,9:111-113.
    • (1999) Chin J Med Chem , vol.9 , pp. 111-113
    • Fu, X.C.1    Hu, Y.Z.2    Zhou, Q.T.3
  • 161
    • 50249132924 scopus 로고    scopus 로고
    • Preparation and release characteristics of berberine chitosan nanoparticles in vitro [J]
    • Lin AH, LI HY, Liu YM, et al. Preparation and release characteristics of berberine chitosan nanoparticles in vitro [J]. China Pharm, 2007,18:755-757.
    • (2007) China Pharm , vol.18 , pp. 755-757
    • Lin, A.H.1    LI, H.Y.2    Liu, Y.M.3


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