Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate

Biopharmaceutics and Drug Disposition

Volumn 27, Issue 3, 2006, Pages 111-117

  Hong, Zhanying ^a   Fan, Guorong ^a   Le, Jian ^b   Chai, Yifeng ^a   Yin, Xueping ^a   Wu, Yutian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

Brain pharmacokinetics; Chiral HPLC analysis; Tetrahydropalmatine; Tissue distribution

Indexed keywords

CORYDALIS YANHUSUO EXTRACT; PLANT EXTRACT; TETRAHYDROPALMATINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN CORTEX; BRAIN STEM; CEREBELLUM; CHINESE MEDICINE; CONTROLLED STUDY; CORPUS STRIATUM; CORYDALIS; DIENCEPHALON; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG ISOLATION; DRUG LIVER LEVEL; DRUG STRUCTURE; DRUG TISSUE LEVEL; ENANTIOMER; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; KIDNEY PARENCHYMA; LUNG PARENCHYMA; NONHUMAN; RACEMIC MIXTURE; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPLEEN; TISSUE DISTRIBUTION; TRADITIONAL MEDICINE; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BERBERINE ALKALOIDS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 33646358216     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.489     Document Type: Article

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