Modulation action of berberine on NO-cGMP signal pathway in isolated corpus cavernosum smooth muscle

Chinese Pharmacological Bulletin

Volumn 21, Issue 4, 2005, Pages 435-440

  Tan, Yan ^a,b   Tang, Qiang ^a   Hu, Ben Rong ^a   Xiang, Ji Zhou ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Berberine; Corpus cavernosum; Cyclic guanosine monophosphate; Erectile dysfunction; Nitric oxide synthase

Indexed keywords

BERBERINE; CYCLIC GMP; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; SILDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; MOLECULAR MECHANICS; NONHUMAN; RABBIT; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

EID: 22444448645     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. NIH Consensus Conference. Development panel on impotence[J]. JAMA, 1993, 270: 83-90.
2. Moreland BR, Goldstein I, Kim NN et al. Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: research and clinical implication in erectile dysfunction[J]. TEM, 1999, 10(3): 97-104.
3. Ganzalez-Cadavid NF, Ignarro LJ, Rajfer J. Nitric oxide and the cyclic GMP system in the penis[J]. Mol Urol, 1999; 3 (2): 51-9.
4. Burnett AL. Nitric oxide control of lower genitourinary tract functions: a review[J]. Urology, 1995, 45(6): 1071-83.
5. Ko WH, Yao XQ, Lau CW et al. Vasorelaxation and antiproliferative effects of berberine[J]. Eur J Pharmacol, 2000, 399(2-3): 187-96.
6. Chiou WF, Yen MH, Chen CF. Mechanism of vasodilatory effect of berberine in rat mesenteric artery[J]. Eur J Pharmacol, 1991, 204(1): 35-40.
7. Wu F, Park F, Cowley AM Jr et al. Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney[J]. Am J Physilo Renal Physiol, 1999, 276: F874-81.
8. Simonsen U, García-Sacristán A, Prieto D. penile arteries and erection[J]. J Vasc Res, 2002, 39(4): 283-303.
9. Knispel HH, Goessl C, Beckmann R. Basal and acetylcholine-stimulated nitricoxide formation mediates relaxation of rabbit cavernous smooth muscle[J]. J Urol, 1991, 146(5): 1429-33.
10. Chancellor MB, Tirney S, Mattes CE et al. Nitric oxide synthase gene transfer for erectile dysfunction in a rat model[J]. BJU International, 2003, 91(7): 691-6.
11. Sezen SF. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration[J]. J Androl, 2000, 21(2): 311-5.
12. Nangle MR, Cotter MA, Cameron NE. An in vitro study of corpus cavernosum and aorta from mice lacking the inducible nitric oxide synthase gene[J]. Nitric Oxide, 2003, 9(4): 194-200.