Protective effect of berberine on cyclophosphamide-induced haemorrhagic cystitis in rats

Pharmacology and Toxicology

Volumn 88, Issue 5, 2001, Pages 232-237

  Xu, Xinyun ^a   Malavé, Andrés ^a  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; CYCLOPHOSPHAMIDE; NITRATE; NITRIC OXIDE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EDEMA; HEMORRHAGIC CYSTITIS; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035019158     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.2001.880502.x     Document Type: Article

References (36)

1. Alfieri, A. & C. Gardner: The NK1 antagonist GR 203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. Gen. Pharmacol. 1997, 29, 245-250.
2. Assreuy, A. M. S., G. J. Martins, M. E. F. Moreira, G. A. C. Brito, B. S. Cavada, R. A. Ribeiro & C. A. Flores: Prevention of cyclophosphamide-induced cystitis by glucose-mannose binding plant lectins. J. Urol. 1999, 161, 1988-1993.
3. Assreuy, J., F. Q. Cunha, F. Y. Liew & S. Moncada: Feedback inhibition of nitric oxide synthase activity by nitric oxide. Brit. J. Pharmacol. 1993, 108, 833-837.
4. Bagasra, O., F. H. Michaels, Y. M. Zheng, L. E. Borroski, S. V. Spitsin, Z. F. Fu, R. Tawadros & H. Koprowski: Activation of the inducible form of nitric oxide synthase in the brains of patiens with multiple sclerosis. Proc. Natl. Acad. Sci. USA 1995, 92, 12041-12045.
5. Bennett, A. H.: Cyclophosphamide and hemorrhagic cystitis. J. Urol. 1974, 111, 603-606.
6. Bhat, N. R., P. Zhang, J. C. Lee & E. L. Hogan: Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 1998, 18, 1633-1641.
7. Bova, S., R. Padrini, W. F. Goldman, D. M. Berman & G. Cargnelli: On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system. J. Pharmacol. Exp. Therap. 1992, 261, 318-323.
8. Busse, R. & A. Mulsch: Induction of nitric oxide synthase by cytokines in vascular smooth muscle cell. FEBS Lett. 1990, 275, 87-90.
9. Chiou, W., M. H. Yen & C. F. Chen: Mechanism of vasodilatory effect of berberine in rat mesenteric artery. Eur. J. Pharmacol. 1991, 204, 35-40.
10. Cox, P. J.: Cyclophosphamide cystitis-identification of acrolein as the causative agent. Biochem. Pharmacol. 1979, 28, 2045-2049.
11. Droller, M. J., R. Saral & G. Santos: Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982, 20, 256-258.
12. Ehrlich, R. M., A. Freedman, A. B. Goldsobel, E. R. Stiehm: The use of sodium 2-mercaptoethane sulfonate to prevent cyclophosphamide cystitis. J. Urol. 1984, 131, 960-962.
13. Feinstein, D. L., E. Galea, S. Roberts, H. Berquist, H. Wang & D. J. Reis: Induction of nitric oxide synthase in rat C6 glioma cells. J. Neurochem. 1994, 62, 811-814.
14. Foad, B. S. I. & E. V. Hess: Urinary bladder complications with CY therapy. Arch. Intern. Med. 1976, 136, 616-619.
15. Galea, E., D. L. Feinstein & D. J. Reis: Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc. Natl. Acad. Sci. USA. 1992, 89, 10945-10949.
16. Gray, K. J., U. H. Engelmann, E. H. Johnson & I. J. Fishman: Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (cytoxan) therapy. J. Urol. 1986, 133, 497-500.
17. Grinberg-funes, D. J., C. Sheldon & M. Weiss: The use of prostaglandin F2 alpha for the prophylaxis of cyclophosphamide-induced cystitis in rats. J. Urol. 1990, 144, 1500-1504.
18. Hows, J. M., A. Metha & L. Ward: Comparison of mesna with forced diuresis to prevent cyclophosphamide-induced hemorrhagic cystitis in marrow transplantation: a prospective randomised study. Brit. J. Cancer 1984, 50, 753-756.
19. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon & B. Dietzschold: In vivo expression of nitric oxide synthase in experimentally induced neurological diseases. Proc. Natl. Acad. Sci. USA 1993, 90, 3024-3027.
20. Kranc, D. M., J. Kim, F. Straus & L. A. Levine: Prophylactic and therapeutic carboprost tromethamine bladder irrigation in rats with cyclophosphamide-induced hemorrhagic cystitis. J. Urol. 1992, 148, 1326-1330.
21. Lecci, A., S. Giuliani, P. Santiciolo & C. A. Maggi: Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anesthetized rats. Eur. J. Pharmacol. 1994, 259, 129-135.
22. Leone, A. M., R. M. Palmer, R. G. Knowles, P. L. Francis, D. S. Ashton & S. Moncada: Constitutive and inducible nitric oxide synthases incorporated molecular oxygen into both nitric oxide and citrulline. J. Biol. Chem. 1991, 266, 23790-23795.
23. McCafferty, D. M., J. S. Mudgett, M. G. Swain & P. Kubes: Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997, 112, 1022-1027.
24. Mohiuddin, J., H. G. Prentice, S. Schey, H. Blacklock & P. Dandona: Treatment of cyclophosphamide-induced cystitis with prostaglandin E2. Ann. Intern. Med. 1984, 101, 142.
25. Olsson, L. E., M. A. Wheeler, W. C. Sessa & R. M. Weiss: Bladder instillation and intraperitoneal injection of escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. J. Pharmacol. Exp. Therap. 1998, 284, 1203-1208.
26. Ozawa, H., M. B. Chancellor, S. Y. Jung, T. Yokoyama, M. O. Fraser, Y. Yu, W. C. de Groat & N. Yoshimura: Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis. J. Urol. 1999, 162, 2211-2216.
27. Parkinson, J. F., B. Mitrovic & J. E. Merrill: The role of nitric oxide in multiple sclerosis. J. Mol. Med. 1997, 75, 174-186.
28. Philips, F. S., S. S. Sternberg, A. P. Cronin & P. N. Vidal: Cyclophosphamide and urinary bladder toxicity. Cancer Res. 1961, 21, 1577-1580.
29. Schmidt, H. H. W., T. D. Warner, M. Nakane, U. Fostermann & F. Murad: Regulation and subcellular location of nitrogen oxide synthase in RAW264.7 macrophages. Mol. Pharmacol. 1992, 41, 615-624.
30. Shurafa, M., E. Shumaker & S. Cronin: Prostaglandin F2-alpha bladder irrigation for control of intractable cyclophosphamide-induced hemorrhagic cystitis. J. Urol. 1987, 137, 1230-1231.
31. Souza-Filho, M. V., M. V. Lima, M. M. Pompeu, G. Ballejo, F. Q. Cunha & R. de. A. Ribeiro: Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Amer. J. Pathol. 1997, 150, 247-256.
32. Stillwell, T. J. & R. C. Benson: Cyclophosphamide-induced hemorrhagic cystitis: a review of 100 patients. Cancer 1988, 61, 451-457.
33. Trigg, M. E., J. O'Reilly, S. Rumelhart, D. Morgan, M. Holida & P. DeAlarcon: Prostaglandin E1 bladder instillations to control severe hemorrhagic cystitis. J. Urol. 1990, 143, 92-94.
34. Wu, S. N., H. S. Yu, C. R. Jan, H. F. Li & C. L. Yu: Inhibitory effects of berberine on voltage-and calcium-activated potassium currents in human myeloma cells. Life Sci. 1998, 62, 2283-2294.
35. Xu, X., L. X. Cubeddu & A. Malave: Expression of inducible nitric oxide synthase in primary culture of rat smooth muscle cells by plasma from cyclophosphamide-treated rats. Eur. J. Pharmacol. 2001, 416, 1-9.
36. Zhang, H., X. Chen, X. Teng, C. Snead & J. D. Catravas: Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells. Biochem. Pharmacol. 1988, 55, 1873-1880.