Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase

Journal of Medicinal Chemistry

Volumn 51, Issue 16, 2008, Pages 4968-4977

  Kumar, Sanjeev ^a   Jaller, Daniel ^b   Patel, Bhumika ^a   LaLonde, Judith M ^a   DuHadaway, James B ^b   Malachowski, William P ^a   Prendergast, George C ^b,c   Muller, Alexander J ^b  

^a BRYN MAWR COLLEGE   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 4 PHENYLIMIDAZOLE; 1 BENZYL 5 PHENYL 1H IMIDAZOLE; 2 (1H IMIDAZOL 4 YL)BENZENE 1,3 DIOL; 2 (1H IMIDAZOL 4 YL)BENZENETHIOL; 2 (1H IMIDAZOL 4 YL)PHENOL; 2 (4 PHENYL 1H IMIDAZOL 1 YL)ETHANAMINE; 2 [2 (4 PHENYL 1H IMIDAZOL 1 YL)ETHYL]ISOINDOLINE 1,3 DIONE; 2 [3 (4 PHENYL 1H IMIDAZOL 1 YL)PROPYL]ISOINDOLINE 1,3 DIONE; 3 (1H 1MIDAZOL 4 YL)PYRIDINE; 3 (1H IMIDAZOL 4 YL)BENZALDEHYDE; 3 (1H IMIDAZOL 4 YL)BENZENETHIOL; 3 (1H IMIDAZOL 4 YL)BENZONITRILE; 3 (1H IMIDAZOL 4 YL)PHENOL; 3 (4 PHENYL 1H IMIDAZOL 1 YL)PROPAN 1 AMINE; 3 (4 PHENYL 1H IMIDAZOL 1 YL)PROPANENITRILE; 3 (4H IMIDAZOL 4 YL)BENZENETHIOL; 3 BENZYL 1 (2 CYANOETHYL) 4 PHENYL 1H IMIDAZOL 3 IUM BROMIDE; 4 (1H IMIDAZOL 4 YL)PHENOL; 4 (2 FIUOROPHENYL) 1H IMIDAZOLE; 4 (2,6 DIMETHOXYPHENYL) 1H IMIDAZOLE; 4 (3 FL0UOROPHENYL) 1H IMIDAZOLE; 4 (4 FLUOROPHENYL) 1H IMIDAZOLE; 4 (THIOPHEN 2 YL) 1H IMIDAZOLE; 4 [2 (METHYLTHIO)PHENYL] 1H IMIDAZOLE; 4 [3 (METHYLTHIO)PHENYL] 1H IMIDAZOLE; 4 [4 (METHYLTHIO)PHENYL] 1H IMIDAZOLE; ALKYLARYLIMIDAZOLE; IMIDAZOLE DERIVATIVE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACID SEQUENCE; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; ENZYME INHIBITORS; HEME; HUMANS; IMIDAZOLES; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INHIBITORY CONCENTRATION 50; IRON; MODELS, MOLECULAR; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50249098630     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800512z     Document Type: Article

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