Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: Ketimine and pyridoxamine phosphate forms

Biochemistry

Volumn 41, Issue 39, 2002, Pages 11592-11601

  Yennawar, Neela H ^a   Conway, Myra E ^b   Yennawar, Hemant P ^a   Farber, Gregory K ^a,c   Hutson, Susan M ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGES;

AMINO ACIDS; CONFORMATIONS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS;

BIOCHEMISTRY;

AMINO ACID; AMINOTRANSFERASE; ISOLEUCINE; KETIMINE; LYSINE; PYRIDOXAMINE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY; STRUCTURE ANALYSIS; TRANSAMINATION;

ALANINE TRANSAMINASE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; D-ALANINE TRANSAMINASE; ESCHERICHIA COLI PROTEINS; HUMANS; ISOENZYMES; ISOLEUCINE; LYSINE; MITOCHONDRIA; MODELS, MOLECULAR; OXO-ACID-LYASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PYRIDOXAMINE; SCHIFF BASES; SUBSTRATE SPECIFICITY; TRANSAMINASES; VALINE;

MAMMALIA;

EID: 0036785129     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020221c     Document Type: Article

References (42)

1. Ichihara, A. (1985) Aminotransferases of branched chain amino acids in transaminases (Christen, P., and Metzler, D. E., Eds.) Vol. 2, pp 430-439, Wiley and Sons, New York.
2. Conway, M. E., and Hutson, S. M. (2000) Methods Enzymol. 324, 355-365.
3. Hutson, S. M. (2001) Prog. Nucleic Acid Res. Mol. Biol. 70, 175-206.
4. Hutson, S. M. (1988) J. Nutr. 118, 1475-1481.
5. Hutson, S. M., Fenstermacher, D., and Mahar, C. (1988) J. Biol. Chem. 263, 3618-3625.
6. Hutson, S. M., Wallin, R., and Hall, T. R. (1992) J. Biol. Chem. 267, 15681-15686.
7. Hall, T. R., Wallin, R., Reinhart, G. D., and Hutson, S. M. (1993) J. Biol. Chem. 268, 3092-3098.
8. Hutson, S. M., Bledsoe, R. K., Hall, T. R., and Dawson, P. A. (1995) J. Biol. Chem. 270, 30344-30352.
9. Bledsoe, R. K., Dawson, P. A., and Hutson, S. M. (1997) Biochim. Biophys. Acta 1339, 9-13.
10. Davoodi, J., Drown, P. M., Bledsoe, R. K., Wallin, R., Reinhart, G. D., and Hutson, S. M. (1998) J. Biol. Chem. 273, 4982-4989.
11. Hutson, S. M., Berkich, D., Drown, P., Xu, B., Aschner, M., and LaNoue, F. (1998) J. Neurochem. 71, 863-874.
12. Yennawar, N., Dunbar, J., Conway, M., Hutson, S., and Farber, G. Acta Crystallogr. D57, 506-515.
13. Okada, K., Hirotsu, K., Sato, M., Hayashi, H., and Kagamiyama, H. (1997) J. Biochem. 121, 637-641.
14. Conway, M. E., Yennawar, N., Wallin, R., Poole, L. B., and Hutson, S. M. (2002) Biochemistry (in press).
15. Rhee, S., Silva, M. M., Hyde, C. C., Rogers, P. H., Metzler, C. M., Metzler. D. E., and Arnone, A. (1997) J. Biol. Chem. 272, 17293-17302.
16. Grishin, N. V., Phillips, M. A., and Goldsmith, E. J. (1995) Protein Sci. 4, 1291-1304.
17. Yoshimura, T., Nishimura, K., Ito, J., Esaki, N., Kagamiyama, H., Manning, J. M., and Soda, K. (1993) J. Am. Chem. Soc. 115, 3897-3900.
18. Sugio, S., Petsko, G. A., Manning, J. M., Soda, K., and Ringe, D. (1995) Biochemistry 34, 9661-9669.
19. Sugio, S., Kashima, A., Kishimoto, K., Peisach, D., Petsko, G. A., Ringe, D., Yoshimura, T., and Esaki, N. (1998) Protein Eng. 11, 613-619.
20. Peisach, D., Chipman, D. M., Van Ophem, P. W., Manning, J. M., and Ringe, D. (1998) Biochemistry 37, 4958-4967.
21. Nakai, T., Mizutani, H., Miyahara, I., Hirotsu, K., Takeda, S., Jhee, K. H., Yoshimura, T., and Esaki, N. (2000) J. Biochem. 128, 29-38.
22. Okada, K., Hirotsu, K., Hayashi, H., and Kagamiyama, H. (2001) Biochemistry 40, 7453-7463.
23. Kirsch, J. F., Eichele, G., Ford, G. C., Vincent, M. G., Jansonius, J. N., Gehring, H., and Christen, P. (1984) J. Mol. Biol. 174, 497-525.
24. Toney, M. D., and Kirsch, J. F. (1993) Biochemistry 32, 1471-1479.
25. Galburt, E., and Stoddard, B. L. (2001) Phys. Today, 54, 33-39.
26. Otwinowski, Z., and Minor, W. (1996) Methods Enzymol. 276, 307-326.
27. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
28. CCP4 Collaborative Computational Project, Number 4 (1994) The CCP4 Suite: Programs for Protein Crystallography, Acta Crystallogr. D50, 760-763.
29. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D54, 905-921.
30. Jones, T. A., and Kjeldgaard, M. (1997) Methods Enzymol. 277, 173-208.
31. Kleywegt, G. J., and Jones, T. A. (1997) Methods Enzymol. 277, 208-230.
32. Kabsch W. (1976) LSQKAB, Acta Crystallogr. A32, 922-923.
33. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
34. Steiner, T., and Koellner, G. (2001) J. Mol. Biol. 305, 535-557.
35. Bondi, A. (1964) J. Phys. Chem. 68, 441-451.
36. Wood, Z. A., Poole, L. B., and Karplus, P. A. (2001) Biochemistry 40, 3900-3911.
37. Kerr, K. A., and Abrahams, J. P. (1975) Acta Crystallogr. B31, 2022-2026.
38. Gehring, H., and Christen, P. (1978) J. Biol. Chem. 253, 3158-3163.
39. Berezov, A., Iriarte A., and Martinez-Carrion M. (1994) J. Biol. Chem. 269, 22222-22229.
40. Schwede, T., Diemand A., Guex N., and Peitsch M. C. (2000) Res. Microbiol. 151, 107-112.
41. Lin, H. M., Kaneshige, M., Zhao, L., Zhang, X., Hanover, J. A., and Cheng, S. Y. (2001) J. Biol. Chem. 276, 48196-48205.
42. Than, N. G., Sumegi, B., Than, G. N., Bellyei, S., and Bohn, H. (2001) Placenta 22, 235-243.