Establishment of an apoptosis-sensitive rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53

Cancer Letters

Volumn 232, Issue 2, 2006, Pages 279-288

  Hamaguchi, Tetsuya ^a   Matsuoka, Yoichiro ^b   Bechberger, John ^c   Ohnishi, Takamasa ^d   Fujita, Ken Ichi ^e   Naus, Christian C ^c   Kusunoki, Masato ^a   Tsubura, Airo ^b   Tsuda, Hiroyuki ^f  

^a MIE UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^f NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Apoptosis; Bcl XL; Mammary carcinoma; p53; ras; Transgenic rat

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; DEATH RECEPTOR; ETOPOSIDE; MUTANT PROTEIN; PACLITAXEL; PROTEIN BCL 2; PROTEIN P53; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CELL LINE; CODON; CONTROLLED STUDY; DNA BINDING; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENIC ANIMAL; WILD TYPE;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BINDING SITES; CELL LINE, TUMOR; DNA; FEMALE; GENES, RAS; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MAP KINASE SIGNALING SYSTEM; POINT MUTATION; RATS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 31644443486     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.02.043     Document Type: Article

References (32)

1. A. Ashkenazi Targeting death and decoy receptors of the tumour-necrosis factor superfamily Nat. Rev. Cancer 2 2002 420 430
2. H. Puthalakath, and A. Strasser Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins Cell Death Differ. 9 2002 505 512
3. S. Cory, and J.M. Adams The Bcl2 family: regulators of the cellular life-or-death switch Nat. Rev. Cancer 2 2002 647 656
4. T. Miyashita, and J.C. Reed Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 80 1995 293 299
5. E. Oda, R. Ohki, H. Murasawa, J. Nemoto, T. Shibue, and T. Yamashita Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis Science 288 2000 1053 1058
6. L.B. Owen-Schaub, W. Zhang, J.C. Cusack, L.S. Angelo, S.M. Santee, and T. Fujiwara Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression Mol. Cell. Biol. 15 1995 3032 3040
7. M. Muller, S. Wilder, D. Bannasch, D. Israeli, K. Lehlbach, and M. Li-Weber p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs J. Exp. Med. 188 1998 2033 2045
8. A. Sigal, and V. Rotter Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome Cancer Res. 60 2000 6788 6793
9. Y. Haupt, S. Rowan, E. Shaulian, K.H. Vousden, and M. Oren Induction of apoptosis in HeLa cells by trans-activation-deficient p53 Genes Dev. 9 1995 2170 2183
10. X. Chen, L.J. Ko, L. Jayaraman, and C. Prives p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells Genes Dev. 10 1996 2438 2451
11. J.M. Kokontis, A.J. Wagner, M. O'Leary, S. Liao, and N. Hay A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function Oncogene 20 2001 659 668
12. N. Baptiste, and C. Prives p53 in the cytoplasm: a question of overkill? Cell 116 2004 487 489
13. M. Mihara, S. Erster, A. Zaika, O. Petrenko, T. Chittenden, P. Pancoska, and U.M. Moll p53 has a direct apoptogenic role at the mitochondria Mol. Cell 11 2003 577 590
14. J.E. Chipuk, T. Kuwana, L. Bouchier-Hayes, N.M. Droin, D.D. Newmeyer, M. Schuler, and D.R. Green Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis Science 303 2004 1010 1014
15. M. Asamoto, T. Ochiya, H. Toriyama-Baba, T. Ota, T. Sekiya, M. Terada, and H. Tsuda Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis Carcinogenesis 21 2000 243 249
16. T. Ota, M. Asamoto, H. Toriyama-Baba, F. Yamamoto, Y. Matsuoka, and T. Ochiya Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis Carcinogenesis 21 2000 1391 1396
17. H. Tsuda, M. Asamoto, T. Ochiya, H. Toriyama-Baba, A. Naito, and T. Ota High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis Mutat. Res. 477 2001 173 182
18. Y. Matsuoka, K. Fukamachi, T. Hamaguchi, H. Toriyama-Baba, H. Kawaguchi, and M. Kusunoki Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents Toxicol. Pathol. 31 2003 632 637
19. B.S. Han, K. Fukamachi, N. Takasuka, T. Ohnishi, M. Maeda, T. Yamasaki, and H. Tsuda Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats Carcinogenesis 23 2002 1209 1215
20. T. Hamaguchi, Y. Matsuoka, H. Kawaguchi, K. Fukamachi, N. Takasuka, and S. Ueda Terminal endbuds and acini as the respective major yargets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras protooncogene transgenic rats Breast Cancer Res. Treat. 83 2004 43 56
21. R.C. Hallowes, P.S. Rudland, R.A. Hawkins, D.J. Lewis, D. Bennet, and H. Durbin Comparison of the effects of hormones on DNA synthesis in cell cultures of nonneoplastic and neoplastic mammary epithelium from rats Cancer Res. 37 1977 2492 2504
22. K. Fukamachi, Y. Matsuoka, C. Kitanaka, Y. Kuchino, and H. Tsuda Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression Biochem. Biophys. Res. Commun. 287 2001 257 263
23. K. Fukamachi, Y. Matsuoka, H. Ohno, T. Hamaguchi, and H. Tsuda Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs J. Biol. Chem. 277 2002 43549 43552
24. J.C. Lacal, S.K. Srivastava, P.S. Anderson, and S.A. Aaronson Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells Cell 44 1986 609 617
25. U. Krengel, L. Schlichting, A. Scherer, R. Schumann, M. Frech, and J. John Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules Cell 62 1990 539 548
26. K. Scheffzek, M.R. Ahmadian, W. Kabsch, L. Wiesmuller, A. Lautwein, F. Schmitz, and A. Wittinghofer The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants Science 277 1997 333 338
27. D.C. Huang, and A. Strasser BH3-Only proteins-essential initiators of apoptotic cell death Cell 103 2000 839 842
28. L. Scorrano, and S.J. Korsmeyer Mechanisms of cytochrome c release by proapoptotic BCL-2 family members Biochem. Biophys. Res. Commun. 304 2003 437 444
29. S. Cory, D.C. Huang, and J.M. Adams The Bcl-2 family: roles in cell survival and oncogenesis Oncogene 22 2003 8590 8607
30. G. Blandino, A.J. Levine, and M. Oren Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy Oncogene 18 1999 477 485
31. P. Dumont, J.I. Leu, A.C. Della Pietra III, D.L. George, and M. Murphy The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nat. Genet. 33 2003 357 365
32. A.D. Cox, and C.J. Der The dark side of Ras: regulation of apoptosis Oncogene 22 2003 8999 9006