Rapid Emergence of Mammary Preneoplastic and Malignant Lesions in Human c-Ha-ras Proto-Oncogene Transgenic Rats: PossiblE Application for Screening of Chemopreventive Agents

Toxicologic Pathology

Volumn 31, Issue 6, 2003, Pages 632-637

  Matsuoka, Yoichiro ^a   Fukamachi, Katsumi ^a   Hamaguchi, Tetsuya ^a   Toriyama Baba, Hiroyasu ^a   Kawaguchi, Hiroaki ^a   Kusunoki, Masato ^a   Yoshida, Hiroki ^b   Tsuda, Hiroyuki ^c  

^a MIE UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Breast cancer; chemoprevention; ductal hyperplasia; isoflavone; mammary gland; N methyl N nitrosourea; ras; transgenic rat

Indexed keywords

CARCINOGEN; ISOFLAVONE DERIVATIVE; METHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREAST ADENOCARCINOMA; BREAST CARCINOMA; BREAST HYPERPLASIA; BREAST TUMOR; CANCER GROWTH; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; EXPOSURE; FEMALE; HISTOPATHOLOGY; INCIDENCE; INJECTION; MAMMARY GLAND; NONHUMAN; ONCOGENE C H RAS; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; SOYBEAN; TRANSGENIC ANIMAL; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTINEOPLASTIC AGENTS; CHEMOPREVENTION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENES, RAS; HUMANS; ISOFLAVONES; MAMMARY NEOPLASMS, ANIMAL; METHYLNITROSOUREA; PRECANCEROUS CONDITIONS; RATS;

ANIMALIA; GLYCINE MAX;

EID: 0242637140     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230390241882     Document Type: Article

References (37)

1. Ando K., Saitoh A., Hino O., Takahashi R., Kimura M., Katsuki M. (1992). Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes. Cancer Res 52: 978-982.
2. Asamoto M., Ochiya T., Toriyama-Baba H., Ota T., Sekiya T., Terada M., Tsuda H. (2000). Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis. Carcinogenesis 21: 243-249.
3. Asamoto M., Toriyama-Baba H., Ohnishi T., Naito A., Ota T., Ando A., Ochiya T., Tsuda H. (2002). Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-Nitrosomethylbenzylamine induction of esophageal tumorigenesis. Jpn J Cancer Res 93: 744-751.
4. Barnes S., Peterson TG (1995). Biochemical targets of the isoflavone genistein in tumor cell lines. Proc Soc Exp Biol Med 208: 103-108.
5. Constantinou A., Huberman E. (1995). Genistein as an inducer of tumor cell differentiation: possible mechanisms of action. Proc Soc Exp Biol Med 208: 109-115.
6. de Camargo JL, Tsuda H., Asamoto M., Tagawa Y., Wada S., Nagase S., Ito N. (1993). Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats. Toxicol Pathol 21: 409-416.
7. Dragan Y., Valdes R., Gomez-Angelats M., Felipe A., Javier Casado F, Pitot H., Pastor-Anglada M. (2000). Selective loss of nucleoside carrier expression in rat hepatocarcinomas. Hepatology 32: 239-246.
8. Fotsis T., Pepper M., Adlercreutz H., Fleischmann G., Hase T., Montesano R., Schweigerer L. (1993). Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci USA 90: 2690-2694.
9. Fotsis T., Pepper MS, Aktas E., Breit S., Rasku S., Adlercreutz H., Wahala K., Montesano R., Schweigerer L. (1997). Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916-2921.
10. French J., Storer RD, Donehower LA (2001). The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens. Toxicol Pathol 29(Suppl): 24-29.
11. Han BS, Fukamachi K., Takasuka N., Ohnishi T., Maeda M., Yamasaki T., Tsuda H. (2002). Inhibitory effects of 17-beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Carcinogenesis 23: 1209-1215.
12. Hully JR, Su Y., Lohse JK, Griep AE, Sattler CA, Haas MJ, Dragan Y., Peterson J., Neveu M., Pitot HC (1994). Transgenic hepatocarcinogenesis in the rat. Am J Pathol 145: 386-397.
13. Lamartiniere CA, Moore J., Holland M., Barnes S. (1995). Neonatal genistein chemoprevents mammary cancer. Proc Soc Exp Biol Med 208: 120-123.
14. Messina MJ, Persky V., Setchell KD, Barnes S. (1994). Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 21: 113-131.
15. Ota T., Asamoto M., Toriyama-Baba H., Yamamoto F., Matsuoka Y., Ochiya T., Sekiya T., Terada M., Akaza H., Tsuda H. (2000). Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis. Carcinogenesis 21: 1391-1396.
16. Ozaki K., Sukata T., Yamamoto S., Uwagawa S., Seki T., Kawasaki H., Yoshitake A., Wanibuchi H., Koide A., Mori Y., Fukushima S. (1998). High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Cancer Res 58: 3806-3811.
17. Page DL, Dupont WD (1993). Anatomic indicators (histologic and cytologic) of increased breast cancer risk. Breast Cancer Res Treat 28: 157-166.
18. Parker SL, Tong T., Bolden S., Wingo PA (1996). Cancer statistics, 1996. CA Cancer J Clin 46: 5-27.
19. Russo J., Wilgus G., Russo IH (1979). Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion. Am J Pathol 96: 721-736.
20. Russo J., Russo IH (1987). Biological and molecular bases of mammary carcinogenesis. Lab Invest 57: 112-137.
21. Russo J., Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ (1990). Comparative study of human and rat mammary tumorigenesis. Lab Invest 62: 244-278.
22. Russo J., Russo IH (1996). Experimentally induced mammary tumors in rats. Breast Cancer Res Treat 39: 7-20.
23. Sato Y., Mukai K., Furuya S., Kameya T., Hirohashi S. (1992). The AMeX method: a multipurpose tissue-processing and paraffin-embedding method. Extraction of protein and application to immunoblotting. Am J Pathol 140: 775-779.
24. Shao ZM, Alpaugh ML, Fontana JA, Barsky SH (1998). Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem 69: 44-54.
25. Shao ZM, Wu J., Shen ZZ, Barsky SH (1998). Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58: 4851-4857.
26. Singh M., McGinley JN, Thompson HJ (2000). A comparison of the histopathology of premalignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human. Lab Invest 80: 221-231.
27. Storer RD, Cartwright ME, Cook WO, Soper KA, Nichols, WW (1995). Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice. Carcinogenesis 16: 285-293.
28. Sukumar S., McKenzie K., Chen Y. (1995). Animal models for breast cancer. Mutat Res 333: 37-44.
29. Tennant RW, Spalding J., French JE (1996). Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens. Mutat Res 365: 119-127.
30. Tennant RW, Stasiewicz S., Mennear J., French JE, Spalding JW (1999). Genetically altered mouse models for identifying carcinogens. IARC Sci Publ 123-150.
31. Thompson HJ, Adlakha H. (1991). Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea. Cancer Res 51: 3411-3415.
32. Thompson HJ, Adlakha H., Singh M. (1992). Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis 13: 1535-1539.
33. Thompson HJ, McGinley JN, Rothhammer K., Singh M. (1995). Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis 16: 2407-2411.
34. Thompson HJ, McGinley JN, Wolfe P., Singh M., Steele VE, Kelloff GJ (1998). Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats. Carcinogenesis 19: 2181-2185.
35. Thorgeirsson SS, Factor VM, Snyderwine EG (2000). Transgenic mouse models in carcinogenesis research and testing. Toxicol Lett 112-113: 553-555.
36. Tsuda H., Asamoto M., Ochiya T., Toriyama-Baba H., Naito A., Ota T., Sekiya T., Terada M. (2001). High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis. Mutat Res 477: 173-182.
37. Yamamoto S., Mitsumori K., Kodama Y., Matsunuma N., Manabe S., Okamiya H., Suzuki H., Fukuda T., Sakamaki Y., Sunaga M., Nomura G., Hioki K., Wakana S., Nomura T., Hayashi Y. (1996). Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17: 2455-2461.