The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons

European Journal of Neuroscience

Volumn 10, Issue 6, 1998, Pages 2173-2184

  Copani, A ^a   Casabona, G ^b   Bruno, V ^b   Caruso, A ^a   Condorelli, D F ^a   Messina, A ^a   Di Giorgi Gerevini, V ^a   Pin, J P ^c   Kuhn, R ^d   Knopfel T ^a   Nicoletti, F ^a,b  

^a UNIVERSITY OF CATANIA   (Italy)

^b IRCCS NEUROMED   (Italy)

^c CNRS UPR9023   (France)

^d CIBA GEIGY LTD   (Switzerland)

Author keywords

Apoptosis; Development; Granule cells; mGlu receptors

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ANTISENSE OLIGONUCLEOTIDE; METABOTROPIC RECEPTOR; POLYPHOSPHOINOSITIDE; POTASSIUM ION; RECEPTOR SUBTYPE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; CULTURE MEDIUM; GRANULE CELL; HYDROLYSIS; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 18144450045     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00230.x     Document Type: Article

References (4)

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2. Aramori, I. & Nakanishi, S. (1992) Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron, 5, 757-765.
3. Aronica, E., Condorelli, D.F., Nicoletti, F., Dell'Albani, P., Amico, C. & Balazs, R. (1993a) Metabotropic glutamate receptors in cultured cerebellar granule cells: developmental profile. J. Neurochem., 60, 559-565.
4. Aronica, E., Dell'Albani, P., Condorelli, D.F., Nicoletti, F., Hack, N. & Balazs, R. (1993b) Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors. Mol. Pharmacol., 44, 981-989.