Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 1, 2008, Pages

  Quinlan, Mark R ^a   Docherty, Neil G ^a,b   Watson, R William G ^a,b   Fitzpatrick, John M ^a,b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Calcium; Tubular epithelium; Ureter

Indexed keywords

CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE; RHO FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; CONNECTIVE TISSUE GROWTH FACTOR; IMMEDIATE EARLY PROTEIN; INTEGRIN; ION CHANNEL; OSTEOPONTIN; SIGNAL PEPTIDE;

CALCIUM TRANSPORT; CELL STRAIN HEK293; ENZYME ACTIVATION; GAP JUNCTION; HUMAN; KIDNEY TUBULE EPITHELIUM; MECHANICAL STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; URETER OBSTRUCTION; ANIMAL; CELL JUNCTION; EPITHELIUM; KIDNEY TUBULE; MECHANORECEPTOR; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; EPITHELIUM; GAP JUNCTIONS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTEGRINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNELS; KIDNEY TUBULES; MECHANORECEPTORS; OSTEOPONTIN; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA1; URETERAL OBSTRUCTION;

EID: 49949084432     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00576.2007     Document Type: Review

References (139)

1. 2+ entry in endothelial cells. J Biol Chem 279: 20941-20949, 2004.
2. Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension 39: 233-238, 2002.
3. Akiyama SK. Integrins in cell adhesion and signaling. Hum Cell 9: 181-186, 1996.
4. Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE 2002: PE6, 2002.
5. Alexander LD, Alagarsamy S, Douglas JG. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells. Kidney Int 65: 551-563, 2004.
6. Arcangeli A, Becchetti A. Complex functional interaction between integrin receptors and ion channels. Trends Cell Biol 16: 631-639, 2006.
7. 2+ influx. J Biol Chem 280: 12908-12916, 2005.
8. Bendig G, Grimmler M, Huttner IG, Wessels G, Dahme T, Just S, Trano N, Katus HA, Fishman MC, Rottbauer W. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev 20: 2361-2372, 2006.
9. Boitano S, Dirksen ER, Sanderson MJ. Intercellular propagation of calcium waves mediated by inositol trisphosphate. Science 258: 292-295, 1992.
10. Bottinger EP. TGF-beta in renal injury and disease. Semin Nephrol 27: 309-320, 2007.
11. Bradley JM, Kelley MJ, Rose A, Acott TS. Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch. Invest Ophthalmol Vis Sci 44: 5174-5181, 2003.
12. Burridge K, Fath K, Kelly T, Nuckolls G, Turner C. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol 4: 487-525, 1988.
13. Chaqour B, Yang R, Sha Q. Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappaB activation. J Biol Chem 281: 20608-20622, 2006.
14. Chaturvedi LS, Marsh HM, Basson MD. Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells. Am J Physiol Cell Physiol 292: C1701-C1713, 2007.
15. Copland IB, Reynaud D, Pace-Asciak C, Post M. Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291: L487-L495, 2006.
16. Correa-Meyer E, Pesce L, Guerrero C, Sznajder JI. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 282: L883-L891, 2002.
17. Critchley DR. Focal adhesions - the cytoskeletal connection. Curr Opin Cell Biol 12: 133-139, 2000.
18. 2+-sensing receptor induces Rho kinase-mediated actin stress fiber assembly and altered cell morphology, but not in response to aromatic amino acids. Am J Physiol Cell Physiol 290: C1543-C1551, 2006.
19. Diamond JR, Kees-Folts D, Ricardo SD, Pruznak A, Eufemio M. Early and persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis. Am J Pathol 146: 1455-1466, 1995.
20. Diamond JR, Kreisberg R, Evans R, Nguyen TA, Ricardo SD. Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat. Kidney Int 54: 1501-1509, 1998.
21. Diamond JR, Ricardo SD, Klahr S. Mechanisms of interstitial fibrosis in obstructive nephropathy. Semin Nephrol 18: 594-602, 1998.
22. Ding G, Pesek-Diamond I, Diamond JR. Cholesterol, macrophages, and gene expression of TGF-β1 and fibronectin during nephrosis. Am J Physiol Renal Fluid Electrolyte Physiol 264: F577-F584, 1993.
23. Du Z, Duan Y, Yan Q, Weinstein AM, Weinbaum S, Wang T. Mechanosensory function of microvilli of the kidney proximal tubule. Proc Natl Acad Sci USA 101: 13068-13073, 2004.
24. Du Z, Yan Q, Duan Y, Weinbaum S, Weinstein AM, Wang T. Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments. Am J Physiol Renal Physiol 290: F289-F296, 2006.
25. Endlich N, Kress KR, Reiser J, Uttenweiler D, Kriz W, Mundel P, Endlich K. Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 12: 413-422, 2001.
26. Felix JA, Woodruff ML, Dirksen ER. Stretch increases inositol 1,4,5-trisphosphate concentration in airway epithelial cells. Am J Respir Cell Mol Biol 14: 296-301, 1996.
27. Felsenfeld DP, Schwartzberg PL, Venegas A, Tse R, Sheetz MP. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol 1: 200-206, 1999.
28. Filipovic D, Sackin H. A calcium-permeable stretch-activated cation channel in renal proximal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 260: F119-F129, 1991.
29. Fujiwara K. Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells. J Intern Med 259: 373-380, 2006.
30. Galbraith CG, Yamada KM, Sheetz MP. The relationship between force and focal complex development. J Cell Biol 159: 695-705, 2002.
31. Ghazi A, Berrier C, Ajouz B, Besnard M. Mechanosensitive ion channels and their mode of activation. Biochimie 80: 357-362, 1998.
32. Glogauer M, Arora P, Chou D, Janmey PA, Downey GP, McCulloch CA. The role of actin-binding protein 280 in integrin-dependent mechanoprotection. J Biol Chem 273: 1689-1698, 1998.
33. Goel M, Sinkins WG, Zuo CD, Estacion M, Schilling WP. Identification and localization of TRPC channels in the rat kidney. Am J Physiol Renal Physiol 290: F1241-F1252, 2006.
34. Guo R, Liu L, Barajas L. RT-PCR study of the distribution of connexin 43 mRNA in the glomerulus and renal tubular segments. Am J Physiol Regul Integr Comp Physiol 275: R439-R447, 1998.
35. Hanley MJ, Davidson K. Isolated nephron segments from rabbit models of obstructive nephropathy. J Clin Invest 69: 165-174, 1982.
36. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379: 91-96, 1996.
37. Haugen E, Nath KA. The involvement of oxidative stress in the progression of renal injury. Blood Purif 17: 58-65, 1999.
38. Hillis GS, Duthie LA, Mlynski R, McKay NG, Mistry S, MacLeod AM, Simpson JG, Haites NE. The expression of connexin 43 in human kidney and cultured renal cells. Nephron 75: 458-463, 1997.
39. Hinman F, Lee-Brown RK. Pyelovenous backflow. Its relation to pelvic reabsorption, to hydronephrosis and to accidents of pyelography. JAMA 82: 607-613, 1924.
40. Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99: 7461-7466, 2002.
41. Hurwitz CG, Hu VY, Segal AS. A mechanogated nonselective cation channel in proximal tubule that is ATP sensitive. Am J Physiol Renal Physiol 283: F93-F104, 2002.
42. Ingber DE. Mechanosensation through integrins: cells act locally but think globally. Proc Natl Acad Sci USA 100: 1472-1474, 2003.
43. Ingber DE. Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol 59: 575-599, 1997.
44. Isaka Y, Tsujie M, Ando Y, Nakamura H, Kaneda Y, Imai E, Hori M. Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction. Kidney Int 58: 1885-1892, 2000.
45. Ito K, Chen J, El Chaar M, Stern JM, Seshan SV, Khodadadian JJ, Richardson I, Hyman MJ, Vaughan ED Jr, Poppas DP, Felsen D. Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats. Am J Physiol Renal Physiol 287: F1283-F1293, 2004.
46. Kaiser E, Chiba P, Zaky K. Phospholipases in biology and medicine. Clin Biochem 23: 349-370, 1990.
47. Kaneto H, Morrissey J, Klahr S. Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation. Kidney Int 44: 313-321, 1993.
48. Kaunas R, Nguyen P, Usami S, Chien S. Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci USA 102: 15895-15900, 2005.
49. Kawahara K, Ogawa A, Suzuki M. Hyposmotic activation of Ca-activated K channels in cultured rabbit kidney proximal tubule cells. Am J Physiol Renal Fluid Electrolyte Physiol 260: F27-F33, 1991.
50. 2+ current in human gastric myocytes. Biochem Biophys Res Commun 352: 503-508, 2007.
51. Kim SW, Lee J, Jung K, Ma SK, Oh Y, Kim WY, Choi KC, Kim J. Diminished expression of sodium transporters in the ureteral obstructed kidney in rats. Nephron Exp Nephrol 96: e67-e76, 2004.
52. Kippenberger S, Bernd A, Loitsch S, Guschel M, Muller J, Bereiter-Hahn J, Kaufmann R. Signaling of mechanical stretch in human keratinocytes via MAP kinases. J Invest Dermatol 114: 408-412, 2000.
53. + channels in A6 cells. Am J Physiol Renal Fluid Electrolyte Physiol 266: F506-F511, 1994.
54. Kopp UC, Cicha MZ. PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels. Am J Physiol Regul Integr Comp Physiol 276: R1241-R1248, 1999.
55. 2-mediated activation of cAMP. Am J Physiol Renal Physiol 285: F472-F483, 2003.
56. Kopp UC, Farley DM, Smith LA. Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P. Am J Physiol Regul Integr Comp Physiol 272: R2009-R2016, 1997.
57. 2+ in JNK activation by mechanical stretch in bladder smooth muscle cells. Am J Physiol Cell Physiol 281: C1165-C1172, 2001.
58. Laszlo K, Juszko J, Balint P. Renal haemodynamics prior to and after release of 24 hr unilateral ureteral ligation in the dog. Acta Physiol Acad Sci Hung 52: 71-86, 1978.
59. Li C, Klein JD, Wang W, Knepper MA, Nielsen S, Sands JM, Frokiaer J. Altered expression of urea transporters in response to ureteral obstruction. Am J Physiol Renal Physiol 286: F1154-F1162, 2004.
60. Li Y, Yang J, Dai C, Wu C, Liu Y. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112: 503-516, 2003.
61. 2+ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct. Am J Physiol Renal Physiol 293: F227-F235, 2007.
62. i response of principal and intercalated cells in cortical collecting duct. Am J Physiol Renal Physiol 285: F998-F1012, 2003.
63. Liu XC, Liu BC, Zhang XL, Li MX, Zhang JD. Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells. Clin Chim Acta 382: 89-94, 2007.
64. Ma MC, Huang HS, Chen CF. Impaired renal sensory responses after unilateral ureteral obstruction in the rat. J Am Soc Nephrol 13: 1008-1016, 2002.
65. Manucha W, Carrizo L, Ruete C, Molina H, Valles P. Angiotensin II type I antagonist on oxidative stress and heat shock protein 70 (HSP 70) expression in obstructive nephropathy. Cell Mol Biol (Noisy-le-grand) 51: 547-555, 2005.
66. Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol 7: 179-185, 2005.
67. Masaki T, Foti R, Hill PA, Ikezumi Y, Atkins RC, Nikolic-Paterson DJ. Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney. Kidney Int 63: 1256-1264, 2003.
68. Matthews BD, Overby DR, Mannix R, Ingber DE. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci 119: 508-518, 2006.
69. 2+ entry. Role in signaling increased endothelial permeability. J Biol Chem 278: 33492-33500, 2003.
70. Milner R, Crocker SJ, Hung S, Wang X, Frausto RF, del Zoppo GJ. Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5. J Immunol 178: 8158-8167, 2007.
71. Minke B, Cook B. TRP channel proteins and signal transduction. Physiol Rev 82: 429-472, 2002.
72. Misseri R, Rink RC, Meldrum DR, Meldrum KK. Inflammatory mediators and growth factors in obstructive renal injury. J Surg Res 119: 149-159, 2004.
73. Miyajima A, Chen J, Kirman I, Poppas DP, Darracott Vaughan EJ, Felsen D. Interaction of nitric oxide and transforming growth factor-beta1 induced by angiotensin II and mechanical stretch in rat renal tubular epithelial cells. J Urol 164: 1729-1734, 2000.
74. Miyajima A, Chen J, Lawrence C, Ledbetter S, Soslow RA, Stern J, Jha S, Pigato J, Lemer ML, Poppas DP, Vaughan ED, Felsen D. Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int 58: 2301-2313, 2000.
75. Moriyama T, Nagatoya K. The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis. Drug News Perspect 17: 29-34, 2004.
76. 2+. J Biol Chem 270: 26270-26277, 1995.
77. Muehlich S, Cicha I, Garlichs CD, Krueger B, Posern G, Goppelt-Struebe M. Actin-dependent regulation of connective tissue growth factor. Am J Physiol Cell Physiol 292: C1732-C1738, 2007.
78. Murata T, Arii S, Nakamura T, Mori A, Kaido T, Furuyama H, Furumoto K, Nakao T, Isobe N, Imamura M. Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells. J Hepatol 35: 474-481, 2001.
79. Naber KG, Madsen PO. Renal function in chronic hydronephrosis with and without infection and the role of the lymphatics. An experimental study in dogs. Urol Res 2: 1-9, 1974.
80. Nagatoya K, Moriyama T, Kawada N, Takeji M, Oseto S, Murozono T, Ando A, Imai E, Hori M. Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int 61: 1684-1695, 2002.
81. Naruse K, Sai X, Yokoyama N, Sokabe M. Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation. FEBS Lett 441: 111-115, 1998.
82. Nguyen HT, Hsieh MH, Gaborro A, Tinloy B, Phillips C, Adam RM. JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp Nephrol 102: e49-e61, 2006.
83. Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
84. Numata T, Shimizu T, Okada Y. TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. Am J Physiol Cell Physiol 292: C460-C467, 2007.
85. Ong AC, Wagner B. Detection of proximal tubular motile cilia in a patient with renal sarcoidosis associated with hypercalcemia. Am J Kidney Dis 45: 1096-1099, 2005.
86. Oudin S, Pugin J. Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch. Am J Respir Cell Mol Biol 27: 107-114, 2002.
87. Pat BK, Cuttle L, Watters D, Yang T, Johnson DW, Gobe GC. Fibrogenic stresses activate different mitogen-activated protein kinase pathways in renal epithelial, endothelial or fibroblast cell populations. Nephrology (Carlton) 8: 196-204, 2003.
88. Pazour GJ. Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease. J Am Soc Nephrol 15: 2528-2536, 2004.
89. Pedersen TS, Hvistendahl JJ, Djurhuus JC, Frokiaer J. Renal water and sodium handling during gradated unilateral ureter obstruction. Scand J Urol Nephrol 36: 163-172, 2002.
90. Peutz-Kootstra CJ, Hansen K, De Heer E, Abrass CK, Bruijn JA. Differential expression of laminin chains and anti-laminin autoantibodies in experimental lupus nephritis. J Pathol 192: 404-412, 2000.
91. Power RE, Doyle BT, Higgins D, Brady HR, Fitzpatrick JM, Watson RW. Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent. J Urol 171: 457-461, 2004.
92. Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184: 71-79, 2001.
93. Pytela R, Pierschbacher MD, Ruoslahti E. Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 40: 191-198, 1985.
94. Radisky DC. Epithelial-mesenchymal transition. J Cell Sci 118: 4325-4326, 2005.
95. Raychowdhury MK, McLaughlin M, Ramos AJ, Montalbetti N, Bouley R, Ausiello DA, Cantiello HF. Characterization of single channel currents from primary cilia of renal epithelial cells. J Biol Chem 280: 34718-34722, 2005.
96. Ricardo SD, Ding G, Eufemio M, Diamond JR. Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors. Am J Physiol Renal Physiol 272: F789-F798, 1997.
97. Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109: 95-104, 2002.
98. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399, 1992.
99. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 153: 1175-1186, 2001.
100. Ruwhof C, van Wamel JT, Noordzij LA, Aydin S, Harper JC, van der Laarse A. Mechanical stress stimulates phospholipase C activity and intracellular calcium ion levels in neonatal rat cardiomyocytes. Cell Calcium 29: 73-83, 2001.
101. Rychkov G, Barritt GJ. TRPC1 Ca(2+)-permeable channels in animal cells. Handbook Exp Pharmacol 23-52, 2007.
102. Sadoshima J, Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59: 551-571, 1997.
103. Sadoshima J, Izumo S. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J 12: 1681-1692, 1993.
104. Sakai K, Mohtai M, Iwamoto Y. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: modulation by cation channel blockades. Calcif Tissue Int 63: 515-520, 1998.
105. Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeifer A, Yurchenco PD, Fassler R. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17: 926-940, 2003.
106. Sanchez-Esteban J, Wang Y, Gruppuso PA, Rubin LP. Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway. Am J Respir Cell Mol Biol 30: 76-83, 2004.
107. 2+ in epithelial cells. Cell Regul 1: 585-596, 1990.
108. Sasamoto A, Nagino M, Kobayashi S, Naruse K, Nimura Y, Sokabe M. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol 288: C1012-C1022, 2005.
109. Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112: 1486-1494, 2003.
110. Schnaper HW, Hayashida T, Poncelet AC. It's a Smad world: regulation of TGF-beta signaling in the kidney. J Am Soc Nephrol 13: 1126-1128, 2002.
111. Schulsinger DA, Gulmi FA, Chou SY, Mooppan UM, Kim H. Activation of endothelium-derived relaxing factor system in acute unilateral ureteral obstruction. J Urol 157: 1951-1956, 1997.
112. Schwartz MA. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. J Cell Biol 120: 1003-1010, 1993.
113. Sharma CP, Ezzell RM, Arnaout MA. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J Immunol 154: 3461-3470, 1995.
114. Shi F, Chiu YJ, Cho Y, Bullard TA, Sokabe M, Fujiwara K. Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch. Cardiovasc Res 73: 813-822, 2007.
115. Shimizu Y, Dobashi K, Iizuka K, Horie T, Suzuki K, Tukagoshi H, Nakazawa T, Nakazato Y, Mori M. Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis. Am J Respir Crit Care Med 163: 210-217, 2001.
116. Sinkins WG, Estacion M, Schilling WP. Functional expression of TrpC1: a human homologue of the Drosophila Trp channel. Biochem J 331: 331-339, 1998.
117. Smith PG, Roy C, Zhang YN, Chauduri S. Mechanical stress increases RhoA activation in airway smooth muscle cells. Am J Respir Cell Mol Biol 28: 436-442, 2003.
118. Sugiyama H, Kobayashi M, Wang DH, Sunami R, Maeshima Y, Yamasaki Y, Masuoka N, Kira S, Makino H. Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. Nephrol Dial Transplant 20: 2670-2680, 2005.
119. Sunami R, Sugiyama H, Wang DH, Kobayashi M, Maeshima Y, Yamasaki Y, Masuoka N, Ogawa N, Kira S, Makino H. Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction. Am J Physiol Renal Physiol 286: F1030-F1038, 2004.
120. Thomas RA, Norman JC, Huynh TT, Williams B, Bolton SJ, Wardlaw AJ. Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway. Respir Med 100: 1588-1597, 2006.
121. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci USA 96: 3934-3939, 1999.
122. Ubl J, Murer H, Kolb HA. Ion channels activated by osmotic and mechanical stress in membranes of opossum kidney cells. J Membr Biol 104: 223-232, 1988.
123. Vaughan ED Jr, Sorenson EJ, Gillenwater JY. The renal hemodynamic response to chronic unilateral complete ureteral occlusion. Invest Urol 8: 78-90, 1970.
124. Vuruskan H, Caliskan Z, Kordan Y, Ozakin C, Yavascaoglu I, Oktay B. Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction. Urol Res 33: 465-469, 2005.
125. Wang JG, Miyazu M, Matsushita E, Sokabe M, Naruse K. Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. Biochem Biophys Res Commun 288: 356-361, 2001.
126. Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science 260: 1124 -1127, 1993.
127. Watanabe N, Kato T, Fujita A, Ishizaki T, Narumiya S. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol 1: 136-143, 1999.
128. Welch WJ, Wilcox CS, Thomson SC. Nitric oxide and tubuloglomerular feedback. Semin Nephrol 19: 251-262, 1999.
129. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C. TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92: 9652-9656, 1995.
130. White LR, Blanchette JB, Ren L, Awn A, Trpkov K, Muruve DA. The characterization of α5-integrin expression on tubular epithelium during renal injury. Am J Physiol Renal Physiol 292: F567-F576, 2007.
131. Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 273: 528-536, 1998.
132. Yeum CH, Kim SW, Lee SC, Choi KC, Ahn KY, Lee J. Diminished expression of aquaporin water channels in ureteral-obstructed kidney in rats. Scand J Urol Nephrol 37: 99-105, 2003.
133. Yoder BK. Role of primary cilia in the pathogenesis of polycystic kidney disease. J Am Soc Nephrol 18: 1381-1388, 2007.
134. Yokoi H, Mukoyama M, Nagae T, Mori K, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Nishida T, Takigawa M, Sugawara A, Nakao K. Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol 15: 1430-1440, 2004.
135. Yoshigi M, Clark EB, Yost HJ. Quantification of stretch-induced cytoskeletal remodeling in vascular endothelial cells by image processing. Cytometry A 55: 109-118, 2003.
136. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276: 13365-13371, 2001.
137. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968, 2003.
138. Zhang SJ, Truskey GA, Kraus WE. Effect of cyclic stretch on β1D-integrin expression and activation of FAK and RhoA. Am J Physiol Cell Physiol 292: C2057-C2069, 2007.
139. 12/13-Rho and calmodulin-dependent kinase in renal epithelial cells. Am J Physiol Renal Physiol 289: F826 -F834, 2005.