Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 12, 2003, Pages 5174-5181

  Bradley, John M B ^a   Kelley, Mary J ^a   Rose, Anastasia ^a   Acott, Ted S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BINDING PROTEIN; GELATIN; GELATINASE A; INITIATION FACTOR; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; PROTEIN KINASE B; PROTEIN P70; PROTEIN P85; PYRIMIDINE; RAPAMYCIN; S 209; S 473; S6 KINASE; T 308; T 389; T 70; TRANSLATION INITIATION FACTOR EIF 4E; UNCLASSIFIED DRUG; WORTMANNIN;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HOMEOSTASIS; INTRAOCULAR PRESSURE; MECHANICAL STIMULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; STRETCHING; STRUCTURE ANALYSIS; SWINE; TRABECULAR MESHWORK; TRANSLATION INITIATION; WESTERN BLOTTING; ZYMOGRAPHY;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-4E; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; SWINE; TRABECULAR MESHWORK;

EID: 0344851562     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0213     Document Type: Article

References (62)

1. Quigley HA. Open-angle glaucoma. N Engl J Med. 1993;328:1097-1106.
2. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996;80:389-393.
3. Acott TS, Wirtz MK. Biochemistry of aqueous outflow. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. Vol. 1. St. Louis: Mosby; 1996:281-305.
4. Acott TS. Biochemistry of aqueous humor outflow. In: Kaufman PL, Mittag TW, eds. Textbook of Ophthalmology. Vol. 7. London: Mosby; 1994:1.47-1.78.
5. Alexander JP, Samples JR, Van Buskirk EM, Acott TS. Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork. Invest Ophthalmol Vis Sci. 1991;32:172-180.
6. Acott TS. Trabecular extracellular matrix regulation. In: Drance SM, Van Buskirk EM, Neufeld AH, eds. Pharmacology of Glaucoma. Baltimore; Williams & Wilkins; 1992:125-157.
7. Bradley JMB, Vranka JA, Colvis CM, et al. Effects of matrix metalloproteinase activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci. 1998;39:2649-2658.
8. Parshley DE, Bradley JMB, Fisk A, et al. Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells. Invest Ophthalmol Vis Sci. 1996;37:795-804.
9. Parshley DE, Bradley JMB, Samples JR, Van Buskirk EM, Acott TS. Early changes in matrix metalloproteinases and inhibitors after in vivo laser treatment to the trabecular meshwork. Cur Eye Res. 1995;14:537-544.
10. Bradley JMB, Anderssohn AM, Colvis CM, et al. Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα. Invest Ophthalmol Vis Sci. 2000;41:422-430.
11. Bill A, Maepea O. Mechanisms and routes of aqueous humor drainage. In: Albert DM, Jakotiec FA, eds. Principles and Practices of Ophthalmology. Vol. 1. Philadelphia; WB Saunders; 1994:206-226.
12. Acott TS. Receptor biology and glaucoma: integrins in the eye. In: Anderson DR, Drance SM, eds. Encounters in Glaucoma Research 1: Receptor Biology and Glaucoma. Milan, Italy: Foglizza Editore; 1994:97-135.
13. Zhou LL, Zhang S-R, Yue BYJT. Adhesion of human trabecular meshwork cells to extracellular matrix proteins: Roles and distribution of integrin receptors. Invest Ophthalmol Vis Sci. 1996;37:104-113.
14. Bradley JMB, Kelley MJ, Zhu XH, Anderssohn AM, Alexander JP, Acott TS. Effects of mechanical stretching on trabecular matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2001;42:1505-1513.
15. Tumminia SJ, Mitton KP, Arora J, Zelenka P, Epstein PL, Russell P. Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1998;39:1361-1371.
16. WuDunn D. The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells. Curr Eye Res. 2001;22:394-397.
17. Okada Y, Matsuo T, Ohtsuki H. Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching. Jpn J Ophthalmol. 1998;42:90-94.
18. Sato Y, Matouo T, Ohtsuki H. A novel gene (oculomedin) induced by mechanical stretching of human trabecular cells of the eye. Biochem Biophys Res Commun. 1999;259:349-351.
19. Stamer WD, Roberts BC, Epstein DL. Hydraulic pressure stimulates adenosine 3′,5′-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. Invest Ophthalmol Vis Sci. 1999;40:1983-1988.
20. Mitton KP, Tumminia SJ, Arora J, Zelenka P, Epstein DL, Russell P. Transient loss of αB-crystallin: an early cellular response to mechanical stretch. Biochem Biophys Res Commun. 1997;235:69-73.
21. Tamm ER, Russell P, Epstein DL, Johnson DH, Piatigorsky J. Modulation of myocillin: TIGR expression in human trabecular meshwork. Invest Ophthalmol Vis Sci. 1999;40:2577-2582.
22. Gonzalez P, Epstein DL, Borras T. Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2000;41:352-361.
23. Borras T, Rowlette LL, Tamm ER, Gottanka J, Epstein DL. Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. Invest Ophthalmol Vis Sci. 2002;43:33-40.
24. Alexander JP, Acott TS. Involvement of protein kinase C in TNFα regulation of trabecular matrix metalloproteinases and TIMPs. Invest Ophthalmol Vis Sci. 2001;42:2831-2838.
25. Alexander JP, Samples JR, Acott TS. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr Eye Res. 1998;17:276-285.
26. Alexander JP, Acott TS. Involvement of Erk-MAP kinase pathway in TNFα regulation of trabecular metalloproteinases and TIMPs. Invest Ophthalmol Vis Sci. 2003;44:164-169.
27. Shearer T, Crosson C. Activation of extracellular signal-regulated kinase in trabecular meshwork cells. Exp Eye Res. 2001;73:25-35.
28. Polansky JR, Wood IS, Maglio MT, et al. Trabecular meshwork cell culture in glaucoma research: evaluation of biological activity and structural properties of human trabecular cells in vitro. Ophthalmology. 1984;91:580-595.
29. Polansky JR, Weinreb R, Alvarado JA. Studies on human trabecular cells propagated in vitro. Vision Res. 1981;21:155-160.
30. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1989.
31. Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1988.
32. Doering TL, Englund PT, Hart GW. Detection of glycophospholipid anchors on proteins. In: Coligan JE, Dunn BM, Ploegh HL, Speicher DW, Wingfield PT, eds. Current Protocols in Protein Science. Vol. 2. New York: John Wiley & Sons; 1998:12.5.1-12.5.14.
33. Alexander JP, Bradley JMB, Gabourel JD, Acott TS. Expression of matrix metalloproteinases and inhibitor by human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1990;31:2520-2528.
34. Samples JR, Alexander JP, Acott TS. Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest Ophthalmol Vis Sci. 1993;34:3386-3395.
35. Mathews DH, Sabina J, Zuker M, Turner DH. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol. 1999;288:911-940.
36. Zuker M, Mathews DH, Turner DH. Algorithms and thermodynamics for RNA secondary structure prediction: a practical guide. In: Barciszewski J, Clark BFC, eds. RNA Biochemistry and BioTechnology. Kluwer Academic Publishers; 1999:11-43.
37. Gingras A-C, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807-826.
38. Proud CG, Denton RM. Molecular mechanisms for the control of translation of insulin. Biochem J. 1997;328:328-341.
39. Raught B, Gingras A-C, Sonenberg N. The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA. 2001;98:7037-7044.
40. Park B-K, Zeng Z, Glazer RI. Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res. 2001;61:7647-7653.
41. Gingras A-C, Raught B, Gygi S, et al. Hierarchical phosphorylation of the translational inhibitor 4E-BP1. Genes Dev. 2001;15:2852-2864.
42. Svitkin YV, Pause A, Haghighat A, et al. The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is directly proportional to the degree of mRNA 5′ secondary structure. RNA. 2001;7:382-394.
43. van der Velden AW, Thomas AAM. The role of the 5′ untranslated region of an mRNA in translation regulation during development. Int J Biochem Cell Biol. 1999;31:87-106.
44. Dever T. Gene-specific regulation by general translation factors. Cell. 2002;108:545-556.
45. Jefferies H, Fumagalli S, Dennis P, Reinhard C, Pearson R, Thomas G. Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70 S6K. EMBO J. 1997;16:3693-3704.
46. Kozak M. The scanning model for translation: an update. J Cell Biol. 1989;108:229-241.
47. Yue BYJT. The extracellular matrix and its modulation in the trabecular meshwork. Surv Ophthalmol. 1996;40:379-390.
48. Geiger B, Bershadsky A, Pankov R, Yamada K. Transmembrane extracellular matrix-cytoskeleton crosstalk. Nat Mol Cell Biol. 2001;2:793-806.
49. Schoenwaelder S, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol. 1999;11:274-286.
50. Geiger B, Bershadsky A. Assembly and mechanosensory function of focal contacts. Curr Opin Cell Biol. 2001;13:584-592.
51. Plopper GE, McNamee HP, Dike LE, Bojanowski K, Ingber DE. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell. 1995;6:1349-1365.
52. Toker A, Cantley L. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 1997;387:673-676.
53. Carpenter C, Cantley L. Phosphoinositide kinases. Curr Opin Cell Biol. 1996;8:153-158.
54. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA. 1998;95:11211-11216.
55. Persad S, Attwell S, Gray V, et al. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA. 2000;97:3207-3212.
56. Persad S, Attwell S, Gray V, et al. Regulation of protein kinase B/AKT-serine 473 phosphorylation by integrin-linked kinase. J Biol Chem. 2001;276:27462-27469.
57. Toker A, Newton A. Cellular signaling: pivoting around PDK-1. Cell. 2000;103:185-188.
58. Shi Y, Hsu J-H, Hu L, Gera J, Lichtenstein A. Signal pathways involved in activation of p70 S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6. J Biol Chem. 2002; 277:15712-15720.
59. Liu G, Zhang Y, Bode A, Ma W-Y, Dong Z. Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J Biol Chem. 2002;277:8810-8816.
60. Kim S, Jung Y, Kim D, Koh H, Chung J. Extracellular zinc activates p70 S6 kinase through phosphatidylinositol 3-kinase signaling pathway. J Biol Chem. 2000;275:25979-25984.
61. Proud CG, Wang X, Patel J, et al. Interplay between insulin and nutrients in the regulation of translation factors. Biochem Soc Trans. 2001;29:541-547.
62. Johnstone MA, Grant WG. Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes. Am J Ophthalmol. 1973;75:365-383.