Integrins play a critical role in mechanical stress-induced p38 MAPK activation

Hypertension

Volumn 39, Issue 2 I, 2002, Pages 233-238

  Aikawa, Ryuichi ^a   Nagai, Toshio ^a   Kudoh, Sumiyo ^a   Zou, Yunzeng ^a   Tanaka, Mariko ^a   Tamura, Masahito ^a   Akazawa, Hiroshi ^a   Takano, Hiroyuki ^a   Nagai, Ryozo ^a   Komuro, Issei ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Hypertrophy, cardiac; Integrins; Myocytes; Protein kinases; Stress, mechanical

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART HYPERTROPHY; HEART MUSCLE CELL; MECHANICAL STRESS; MECHANORECEPTOR; NEWBORN; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HEART VENTRICLES; INTEGRINS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; RATS; RATS, WISTAR; STRESS, MECHANICAL; TUMOR SUPPRESSOR PROTEINS; TYROSINE;

EID: 18244394595     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy0202.102699     Document Type: Article

References (41)

1. Geometric control of cell life and death
2. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
3. Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes
4. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of an autocrine/paracrine mechanism
5. Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes
6. Stretching cardiac myocytes stimulates proto-oncogene expression
7. Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes
8. Load regulation of the properties of adult feline cardiocytes: Growth induction by cellular deformation
9. The mitogen-activated protein kinase signal transduction pathway
10. Activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
11. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
12. Endothelinis involved in mechanical stress-induced cardiomyocyte hypertrophy
13. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy
14. Regulation and function of the JNK subgroup of MAP kinases
15. An osmosensing signal transduction pathway in mammalian cells
16. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
17. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy
18. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-I and phenylephrine: A role in cardiac myocyte hypertrophy?
19. Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas
20. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
21. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
22. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
23. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
24. Integrins and signal transduction pathways: The road taken
25. PTEN interactions with focal adhesion kinase and suppression of the extra-cellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
26. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
27. Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium
28. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
29. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-I kinase and extracellular signal-regulated protein kinases in cardiac myocytes
30. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
31. Grb10/Grb1R as an in vivo substrate of Tec tyrosine kinase
32. Activation of c-Src in cells bearing v-Crk and its suppression by Csk
33. Oxidative stress activates extracellular signal-regulated kinases through src and ras in cultured cardiac myocytes of neonatal rats
34. The MAP kinase cascade is essential for diverse signal transduction pathways
35. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes
36. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
37. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
38. P38 MAPK and NF-κB collaborate to induce interleukin-6 gene expression and release
39. Small GTP-binding proteins and the regulation of the actin cytoskeleton
40. Multiple Grb2-mediated integrinstimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src and focal adhesion kinase-initiated tyrosine phosphorylation events
41. Activators and effectors of ras p21 proteins