Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): Changes in the active-site conformation and interactions with ligands

Acta Crystallographica Section D: Biological Crystallography

Volumn 64, Issue 9, 2008, Pages 909-918

  Elling, Robert A ^a   Fucini, Raymond V ^a   Romanowski, Michael J ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Polo like kinase 1; Small molecule inhibitors; Zebrafish

Indexed keywords

ADENOSINE DIPHOSPHATE; ANDROSTANE DERIVATIVE; CELL CYCLE PROTEIN; LIGAND; ONCOPROTEIN; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; WORTMANNIN; ZEBRAFISH PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; ENZYME ACTIVE SITE; GENETICS; HUMAN; KINETICS; PROTEIN CONFORMATION; VALIDATION STUDY; X RAY CRYSTALLOGRAPHY; ZEBRA FISH;

ADENOSINE DIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANDROSTADIENES; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

BACTERIA (MICROORGANISMS); DANIO RERIO;

EID: 49749134369     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444908019513     Document Type: Article

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