Mechanotransduction and anoikis: Death and the homeless cell

Cell Cycle

Volumn 7, Issue 16, 2008, Pages 2462-2465

  Ma, Zhenyi ^a   Liu, Zhe ^a   Myers, David P ^a   Terada, Lance S ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Focal adhesion; Mechanotransduction; RhoA; Shc; Signal transduction

Indexed keywords

CYTOKERATIN 15; CYTOKERATIN 17; FOCAL ADHESION KINASE; INTEGRIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P46; PROTEIN P66;

ANOIKIS; CELL ADHESION; CELL ANCHORAGE; CELL DEATH; CELL MIGRATION; CELL SHAPE; CELL TRANSFORMATION; CYTOSKELETON; ENZYME RELEASE; HUMAN; MECHANOTRANSDUCTION; METASTASIS; NONHUMAN; PHENOTYPE; PROTEIN FUNCTION; PROTEIN INDUCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 49749116836     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.16.6463     Document Type: Review

References (45)

1. Frisch SM and Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124:619-26.
2. Meredith JE Jr, Fazeli B and Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993; 4:953-61.
3. Plath T, Detjen K, Welzel M, von Marschall Z, Murphy D, Schirner M, Wiedenmann B and Rosewicz S. A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptor. J Cell Biol 2000; 150:1467-78.
4. 1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol 2005; 25:5282-91.
5. Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, Durand RE, Hoodless PA and Karsan A. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res 2004; 94:910-7.
6. Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC and de la Pompa JL. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 2004; 18:99-115.
7. Leong KG, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I and Karsan A. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 2007; 204:2935-48.
8. Coucouvanis E and Martin GR. Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 1995; 83:279-87.
9. Reginato MJ, Mills KR, Paulus JK, Lynch DK., Sgroi DC, Debnath J, Muthuswamy SK and Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003; 5:733-40.
10. Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A and Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell 2007; 12:221-34.
11. Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP and Brugge JS. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci USA 2007; 104:3787-92.
12. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E and Peeper DS. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 2004; 430:1034-9.
13. Shc mediates anoikis through RhoA. J Cell Biol 2007; 179:23-31.
14. Cardone MH, Salvesen GS, Widmann C, Johnson G and Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 1997; 90:315-23.
15. Frisch SM. Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis. Curr Biol 1999; 9:1047-9.
16. Aoudjit F and Vuori K. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol 2001; 152:633-43.
17. Wang P, Valentijn AJ, Gilmore AP and Streuli CH. Early events in the anoikis program occur in the absence of caspase activation. J Biol Chem 2003; 278:19917-25.
18. Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, Ong E, Fukuda M and Ruoslahti E. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/ TLE corepressors. Cell 2004; 116:751-62.
19. Frisch SM, Vuori K, Ruoslahti E and Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996; 134:793-9.
20. Diaz-Montero CM, Wygant JN and McIntyre BW. PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur J Cancer 2006; 42:1491-500.
21. Attwell S, Roskelley C and Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 2000; 19:3811-5.
22. Wei L, Yang Y, Zhang X and Yu Q. Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis. Oncogene 2004; 23:9052-61.
23. McFall A, Ulku A, Lambert QT, Kusa A, Rogers-Graham K and Der CJ. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol 2001; 21:5488-99.
24. Hoshiba T, Nagahara H, Cho CS, Tagawa Y and Akaike T. Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling. Biomaterials 2007; 28:1093-104.
25. Re F, Zanetti A, Sironi M, Polentarutti N, Lanfrancone L, Dejana E and Colotta F. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 1994; 127:537-46.
26. Grinnell F, Zhu M, Carlson MA and Abrams JM. Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue. Exp Cell Res 1999; 248:608-19.
27. Chen CS, Mrksich M, Huang S, Whitesides GM and Ingber DE. Geometric control of cell life and death. Science 1997; 276:1425-8.
28. Engler AJ, Sen S, Sweeney HL and Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126:677-89.
29. McBeath R, Pirone DM, Nelson CM, Bhadriraju K and Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 2004; 6:483-95.
30. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B and Bershadsky AD. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol 2001; 153:1175-86.
31. Choquet D, Felsenfeld DP and Sheetz MP. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 1997; 88:39-48.
32. Discher DE, Janmey P and Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science 2005; 310:1139-43.
33. shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J 1997; 16:706-16.
34. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S and Shyy JY. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins and Shc. J Biol Chem 1999; 274:18393-400.
35. Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J Biol Chem 2004; 279:43900-9.
36. Bharadwaj S, Thanawala R, Bon G, Falcioni R and Prasad GL. Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion. Oncogene 2005; 24:8291-303.
37. Raval GN, Bharadwaj S, Levine EA, Willingham MC, Geary RL, Kute T and Prasad GL. Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors. Oncogene 2003; 22:6194-203.
38. Badock V, Steinhusen U, Bommert K, Wittmann-Liebold B and Otto A. Apoptosisinduced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line. Cell Death Differ 2001; 8:308-15.
39. Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999; 3:287-96.
40. Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC and Strasser A. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001; 293:1829-32.
41. Shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999; 402:309-13.
42. Shc and its association with 14-3-3 protein in glomerular mesangial cells. J Biol Chem 2001; 276:26640-7.
43. Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD and Pawson T. Proteomic, functional and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 2004; 14:1436-50.
44. Li Z, Zhao J, Du Y, Park HR, Sun SY, Bernal-Mizrachi L, Aitken A, Khuri FR and Fu H. Downregulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci USA 2008; 105:162-7.
45. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA and Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell 2005; 8:241-54.