Discovery of (-)-7-methyl-2-exo-[3′-(6-[18F]nuoropyridin- 2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (α4β2-nAChR) with optimal positron emission tomography imaging properties

Journal of Medicinal Chemistry

Volumn 51, Issue 15, 2008, Pages 4751-4764

  Gao, Yongjun ^a   Kuwabara, Hiroto ^a   Spivak, Charles E ^b   Xiao, Yingxian ^c   Kellar, Kenneth ^c   Ravert, Hayden T ^a   Kumar, Anil ^a   Alexander, Mohab ^a   Hilton, John ^a   Wong, Dean F ^a   Dannals, Robert F ^a   Horti, Andrew G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYL 2 EXO[3' (2 FLUOROPYRIDIN 3 YL) 5' PYRIDINYL] 7 AZABICYCLO[2.2.1]HEPTANE F 18; 7 METHYL 2 EXO[3' (2 FLUOROPYRIDIN 4 YL) 5' PYRIDINYL] 7 AZABICYCLO[2.2.1]HEPTANE F 18; 7 METHYL 2 EXO[3' (6 FLUOROPYRIDIN 2 YL) 5' PYRIDINYL] 7 AZABICYCLO[2.2.1]HEPTANE F 18; EPIBATIDINE; NICOTINIC RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG BINDING; DRUG METABOLISM; LIPOPHILICITY; MOUSE; NONHUMAN;

2,2'-DIPYRIDYL; ANIMALS; BRAIN; CELL LINE; HEPTANES; HUMANS; HYDROPHOBICITY; LIPIDS; MALE; MICE; MOLECULAR STRUCTURE; NICOTINIC ANTAGONISTS; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TROPANES;

EID: 49449109015     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800323d     Document Type: Article

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